DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and MYA1

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_173201.2	Gene:	MYA1 / 838333	AraportID:	AT1G17580	Length:	1520	Species:	Arabidopsis thaliana

Alignment Length:	893	Identity:	315/893 - (35%)
Similarity:	490/893 - (54%)	Gaps:	69/893 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLP-IYTDDHVKAYR 96
            |....||.|...| :|..|...:.||:.|::.:.||||.|.:||:|||:::|| ||..|.::.|:
plant    55 EAPSGGVDDMTKL-SYLHEPGVLRNLETRYELNEIYTYTGNILIAVNPFQRLPHIYETDMMEQYK 118

  Fly    97 NKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG- 160
            .....|:.||:||:.|.|:|::|.|.:...:|:|||||:||||.:|.:::::|.. |.::.|||
plant   119 GIALGELSPHVFAIGDAAYRAMINEGKNNSILVSGESGAGKTETTKMLMRYLAFL-GGRSGVEGR 182

  Fly   161 -VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGG 224
             |:.::|:|||||||||||||.||:|||||||:::||||..|...|..|..||||:|||......
plant   183 TVEQQVLESNPVLEAFGNAKTLRNNNSSRFGKFVEIQFDKNGRISGAAIRTYLLERSRVCQISDP 247

  Fly   225 ERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTK 289
            |||:|.||.|.|...|. :::.:||.. ..:.||.......:..::||..:.:.::|:.|:..:.
plant   248 ERNYHCFYLLCAAPPED-IKKYKLENP-HKFHYLNQSSCYKLDGVDDASEYLETRRAMDVVGISN 310

  Fly   290 EEQREIFGIVASILHLGNVGF---TEVEGNA--KVNSRDLVVTAARLLGVNASELEAALTHRTID 349
            |||..||.:||:||||||:.|   .|::.:.  ..:||..:..||.||..||..||.||..|.:.
plant   311 EEQEAIFRVVAAILHLGNIDFGKGEEIDSSVIKDKDSRSHLNMAAELLMCNAQSLEDALIRRVMV 375

  Fly   350 ARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEI 414
            ...:::|..|:.:.||.:||.|||.:|..||.|:|.::|.|: .::.|:  .:::|:|||||||.
plant   376 TPEEIITRTLDPDNAIASRDTLAKTIYSHLFDWIVNKINTSI-GQDPRS--KSIIGVLDIYGFES 437

  Fly   415 FQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIIS 479
            |:.||||||||||.||||||.|.:...|.||:||.:|.|.|..:|:.||:.:..|||:|..||||
plant   438 FKCNSFEQFCINFTNEKLQQHFNQHVFKMEQEEYTKEEIAWSYIEFIDNQDVLELIEKKPGGIIS 502

  Fly   480 ILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNG 544
            :|||.|:.| :.|.:||.:||.|...:|..:.         |..:.|.:|.:.||||||||..|.
plant   503 LLDEACMFP-KSTHETFSQKLFQTFKEHERFA---------KPKLSRTDFTISHYAGEVTYQSNH 557

  Fly   545 FLDKNNDLLFRDLKETLSKAGNGIVRNCF---PEKELRSLKRPETAITQFRASLNNLMDILMCKE 606
            |:|||.|.:..:.:...:.:....|...|   .|...||.|..... ::|:..|::||:.|...|
plant   558 FIDKNKDYIVAEHQALFTASNCKFVAGLFHALHEDSSRSSKFSSIG-SRFKQQLHSLMESLNGTE 621

  Fly   607 PSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWP 671
            |.||||||||::....:|.:..|:||::..|::|.:|:..||:..|..:..||:|:..|:...
plant   622 PHYIRCIKPNNVLKPGIFENFNVIHQLRCGGVLEAIRISCAGYPTRLAFYDFLDRFGLLAPEV-- 684

  Fly   672 NYKGPGGPKAGVQQLV--KDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHW 734
             .:|....|...|.::  |.|    ..|::|:||:|:| ...:.:.:....|.....|.:||..:
plant   685 -LEGNYDDKVACQMILDKKSL----TDYQIGKTKIFLR-AGQMAELDARRAEVLGNAARVIQRQF 743

  Fly   735 KGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRR-EAA-----DKIRAFI--KGFITRNDA-- 789
            :..|.|:.|..:|...|::||:.|.::|:...||.| |||     ...|.::  |.|:|...:
plant   744 RTCMARKNYRSIRNAAIVLQSFLRGEIARAVHKKLRIEAAALRVQKNFRRYVDRKSFVTTRSSTI 808

  Fly   790 --PNGFNEEFIANAKRMWLLRLAKELPTK-VLDKSWPHAPGHCEEASGILHRLHRLHLAR--IYR 849
              ..|. ...||.::    .||.::.... ||...|     ...:|.....||.:..:..  .:|
plant   809 VLQTGL-RAMIARSE----FRLRRQRKAAIVLQAHW-----RGRQAFSYYTRLQKAAIVTQCAWR 863

  Fly   850 LKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQR 897
            .:|..::.|..::........|..||.....|     |:...:.|:::
plant   864 CRLARRELRMLKMAARDTGALKDAKNKLEQRV-----EELSLRLHLEK 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	272/699 (39%)
		MYSc_Myo1	52..707	CDD:276829	264/667 (40%)
		Myosin_TH1	863..1035	CDD:283635	6/35 (17%)
MYA1	NP_173201.2	Myosin_N	9..47	CDD:397036
		MYSc_Myo11	73..717	CDD:276835	264/667 (40%)
		IQ	850..872	CDD:197470	4/21 (19%)
		Smc	<867..>1114	CDD:224117	7/45 (16%)
		MyosinXI_CBD	1099..1486	CDD:271259
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910