DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and ATM1

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001154628.2	Gene:	ATM1 / 821534	AraportID:	AT3G19960	Length:	1176	Species:	Arabidopsis thaliana

Alignment Length:	975	Identity:	325/975 - (33%)
Similarity:	493/975 - (50%)	Gaps:	170/975 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            ||.|.:.| :|.:|.:.:.||..|:.:|:|||..|.||::|||:|::|:|.:.:::|||.|.  .
plant   166 GVDDLMQL-SYLNEPSVLYNLNYRYNQDMIYTKAGPVLVAVNPFKEVPLYGNRYIEAYRKKS--N 227

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLI----------------SGESGSGKTEASKKVLQFIAAC 151
            ..||::|:.|.|.|.:|.:...|.::|                |||||:||||.:|..:|::||.
plant   228 ESPHVYAIADTAIREMIRDEVNQSIIIRCICIHESMTYSISSSSGESGAGKTETAKIAMQYLAAL 292

  Fly   152 SGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKS 216
            .|.    .|::.::||:||:|||||||||.||||||||||.::|.|...|...|..|..:|||||
plant   293 GGG----SGIEYEILKTNPILEAFGNAKTLRNDNSSRFGKLIEIHFSESGKISGAQIQTFLLEKS 353

  Fly   217 RVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQA 281
            |||....|||::||||||.|||..||.::|.|..|.: |.||......::..::||:.|..|::|
plant   354 RVVQCAEGERSYHIFYQLCAGASPALREKLNLTSAHE-YKYLGQSNCYSINGVDDAERFHTVKEA 417

  Fly   282 LTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAKVN-----------------SRDLVV--- 326
            |.::..:||:|..:|.::|::|.||||.||.::....|.                 .::.::
plant   418 LDIVHVSKEDQESVFAMLAAVLWLGNVSFTVIDNENHVEPVADESFLFHSLGSWCWKQECLLHNM 482

  Fly   327 ---TAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLN 388
               |.|:|:|.|.:||...|:.|.:..|.|.:...|....||.|||||||::|..||.|||:::|
plant   483 CLSTVAKLIGCNINELTLTLSKRNMRVRNDTIVQKLTLPQAIDARDALAKSIYSCLFDWLVEQIN 547

  Fly   389 ISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGI 453
            .||...:.|..|:  :.||||||||.|.||||||||||:.||:|||.|.....|.||:||.::||
plant   548 KSLAVGKRRTGRS--ISILDIYGFESFDKNSFEQFCINYANERLQQHFNRHLFKLEQEEYIQDGI 610

  Fly   454 EWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPA 518
            :|..|::.||:...:|.|:|..|::|:||||...| ..||.|...||.|.|..:.   |......
plant   611 DWTRVDFEDNQNCLSLFEKKPLGLLSLLDEESTFP-NGTDLTLANKLKQHLQSNS---CFRGDKG 671

  Fly   519 HIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKR 583
            .:        |.:|||||||||...|||:||.|||..|..:.||.. :.::...|....|...::
plant   672 KL--------FTVVHYAGEVTYETTGFLEKNRDLLHSDSIQLLSSC-SCLLPQAFASSMLIQSEK 727

  Fly   584 PE---------------TAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQV 633
            |.               :..|:|::.|..||..|....|.:|||||||::|:..|:...|||.|:
plant   728 PVVGPLYKAGGADSQRLSVATKFKSQLFQLMQRLGNTTPHFIRCIKPNNIQSPGVYEQGLVLQQL 792

  Fly   634 KYLGLMENLRVRRAGFAYRRTYEL-FLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKY 697
            :..|::|.|    ....|:|.:.: .|.::..|                            .|.|
plant   793 RCCGVLEVL----CKGPYKRFFIIAILHQFNIL----------------------------PEMY 825

  Fly   698 RVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCR-RKL 761
            :||.||||.|..: :...||......|.|.. :|:.::|...|....:|:..:.|:||:.| .|:
plant   826 QVGYTKLFFRTGQ-IGVLEDTRNRTLHGILR-VQSSFRGYQARCLLKELKRGISILQSFVRGEKI 888

  Fly   762 AQQAA--KKRREAADKIRAFIKGFITR------NDAPNGFNEEFIANAKRMWLLR---------- 808
            .::.|  ::|.:||..|::.:|..|.|      .||     ...|.:|.|.||:|
plant   889 RKEFAELRRRHKAAATIQSQVKSKIARIQYKGIADA-----SVVIQSAIRGWLVRRCSGDIGWLK 948

  Fly   809 -----------------LAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQ 856
                             :..||..:||...  .|....||.:.||.:          ||:....:
plant   949 SGGAKTNELGEVLVKASVLSELQRRVLKAE--AALREKEEENDILQQ----------RLQQYENR 1001

  Fly   857 KRQFELKVLA-EKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKF 920
            ..::|.|:.: |::::.:..:..||:|  ..:..:..|...|.:|  ||...|:...:.|...:|
plant  1002 WSEYETKMKSMEEIWQKQMRSLQSSLS--IAKKSLAVEDSARNSD--ASVNASDATDWDSSSNQF 1062

Fly 921 920
plant 1063 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	273/736 (37%)
		MYSc_Myo1	52..707	CDD:276829	264/709 (37%)
		Myosin_TH1	863..1035	CDD:283635	13/59 (22%)
ATM1	NP_001154628.2	MYSc	160..847	CDD:214580	273/736 (37%)
ATM1	NP_001154628.2	MYSc_Myo8	179..835	CDD:276834	264/709 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910