DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo61F and Myh10

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_006534552.1	Gene:	Myh10 / 77579	MGIID:	1930780	Length:	2007	Species:	Mus musculus

Alignment Length:	1063	Identity:	330/1063 - (31%)
Similarity:	526/1063 - (49%)	Gaps:	211/1063 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNA 114
            :|.:.:.|||.|:...|||||.|...:.:||||.||||:::.::.||.|..:||||||:|::::|
Mouse    97 NEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESA 161

  Fly   115 FRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKD---------------- 163
            :|.::::...|.:|.:||||:||||.:|||:|::|..:.:.   :|.||
Mouse   162 YRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSH---KGRKDHNIPQESPKPVKPQGE 223

  Fly   164 ---KLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
               :||::||:||:||||||.:|||||||||::.|.||..|..:|.||..|||||||.|.|...|
Mouse   224 LERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDE 288

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDG---LNGTVTRINDADSFKQVQQALTVIDF 287
            |.||||||||:||.|.|..:|.|| ..:.|.:|::|   :.|.    .|.|:|::..:|:.::.|
Mouse   289 RTFHIFYQLLSGAGEHLKSDLLLE-GFNNYRFLSNGYIPIPGQ----QDKDNFQETMEAMHIMGF 348

  Fly   288 TKEEQREIFGIVASILHLGNVGFTEVEGN---AKVNSRDLVVTAARLLGVNASELEAALTHRTID 349
            :.||...:..:|:|:|..||:.|.: |.|   |.:....:......|||:|..|...|:....|.
Mouse   349 SHEEILSMLKVVSSVLQFGNISFKK-ERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIK 412

  Fly   350 ARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEI 414
            ...|.|.....:|.|.:|.:|||||.|:|||.|||.|:|.:|.  .|:....:.:|||||.||||
Mouse   413 VGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALD--RTKRQGASFIGILDIAGFEI 475

  Fly   415 FQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVICNLIEE--KHKG 476
            |:.|||||.|||:.||||||||.......||:||:||||||..::: .|.:...:|||.  ...|
Mouse   476 FELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPG 540

  Fly   477 IISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYS 541
            ::::|||||..| :.|||||:|||.|:...|..:    :.|..:|.   :.:|.::||||:|.|.
Mouse   541 VLALLDEECWFP-KATDKTFVEKLVQEQGSHSKF----QKPRQLKD---KADFCIIHYAGKVDYK 597

  Fly   542 VNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPE--------------------- 585
            .:.:|.||.|.|..::...|.::.:..|...:.: |:::::|..
Mouse   598 ADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKD-EIQTIQRASFYDSVSGLHEPPVDRIVGLDQ 661

  Fly   586 -TAITQ--------------------FRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELV 629
             |.:|:                    ::.||..||..|....|:::|||.||..:.|...:..||
Mouse   662 VTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLV 726

  Fly   630 LHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDE 694
            |.|::..|::|.:|:.|.||..|..::.|.:||:.|:.:..|  ||....|...:::::.|..|.
Mouse   727 LDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIP--KGFMDGKQACERMIRALELDP 789

  Fly   695 EKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRR 759
            ..||:|::|:|.|                    |.:.||    ::..:.||:...:|..|:.||.
Mouse   790 NLYRIGQSKIFFR--------------------AGVLAH----LEEERDLKITDIIIFFQAVCRG 830

  Fly   760 KLAQQA-AKKRREAA------------------------DKIRAFIKGFITRNDAPNGFNEEFIA 799
            .||::| |||:::.:                        .|::..::  :||.:      ||.
Mouse   831 YLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQ--VTRQE------EEL-- 885

  Fly   800 NAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQ-KRQFELK 863
            .||...||:: ||..|||               .|.|..:.|.|...:....:..:| :.:.||.
Mouse   886 QAKDEELLKV-KEKQTKV---------------EGELEEMERKHQQLLEEKNILAEQLQAETELF 934

  Fly   864 VLAEKV---FKGKKNNYASSVSTWFQEDRIPKE----------------HIQRVNDFVASTFGSE 909
            ..||::   ...||......:..  .|.|:.:|                |||.:.:.:....|:.
Mouse   935 AEAEEMRARLAAKKQELEEILHD--LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 997

  Fly   910 QLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKI---------------D 959
            | |.|......:....|..:..:||.::     :.|..|:| :|..|:|               :
Mouse   998 Q-KLQLEKVTAEAKIKKMEEEVLLLEDQ-----NSKFIKEK-KLMEDRIAECSSQLAEEEEKAKN 1055

  Fly   960 FTLTNHNDDLMVIRIPLDLKKDK 982
            .....:..::|:..:...|||::
Mouse  1056 LAKIRNKQEVMISDLEERLKKEE 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	267/739 (36%)
		MYSc_Myo1	52..707	CDD:276829	265/724 (37%)
		Myosin_TH1	863..1035	CDD:283635	27/154 (18%)
Myh10	XP_006534552.1	Myosin_N	33..72	CDD:397036
		MYSc_Myh10	99..802	CDD:276952	265/724 (37%)
		Myosin_tail_1	879..1959	CDD:396244	47/233 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000