DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo1h

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_038946123.1	Gene:	Myo1h / 687866	RGDID:	1596237	Length:	1022	Species:	Rattus norvegicus

Alignment Length:	1026	Identity:	502/1026 - (48%)
Similarity:	697/1026 - (67%)	Gaps:	13/1026 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 METGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDH 91
            ||..|..||:.||||||||:.|.||.||:.||:|||:|:|||||||.:|:|||||::|.|||...
  Rat     1 MEGALTARDKVGVQDFVLLDAYTSESAFLENLRKRFRENLIYTYIGTLLVSVNPYQELGIYTSSQ 65

  Fly    92 VKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQT 156
            ::.|:..:|:|:|||::|:.|||:|.:..|.....:|||||||:||||||||:||::|.......
  Rat    66 MELYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYLAVTCPMTE 130

  Fly   157 TVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQ 221
            :::..:|:||.|.|||||||||||.||||||||||||||||||:|.|:||:|::||:||||||.|
  Rat   131 SLQIARDRLLLSIPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFQGVPVGGHIISYLIEKSRVVYQ 195

  Fly   222 MGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVID 286
            ..||||||||||||||.....|..|.|||....|.:|:.|.....:..||...::.|..|.:||.
  Rat   196 NHGERNFHIFYQLLAGGKSERLASLGLERDPQLYKFLSQGHCARESPSNDRSDWETVYSAFSVIG 260

  Fly   287 FTKEEQREIFGIVASILHLGNVGFT-EVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDA 350
            ||:.:...:|||:||:|||||:.|. :.:|.|.:.....:...|:||||..:.|..|||||.|:|
  Rat   261 FTEADLENLFGIIASVLHLGNICFKGDKQGCASIPDTHEIKWIAKLLGVCPAVLLEALTHRKIEA 325

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIF 415
            :.:.|..||..||::|||||:|||||.|.|:|||.::|.||..|:  .::..|:|:|||||||:|
  Rat   326 KTEEVICPLTVELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKD--FTQKTVIGLLDIYGFEVF 388

  Fly   416 QKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISI 480
            .||.|||||||:||||||||.||.|||:||.||..|||||.||:||:||:||:|:||:|:|||||
  Rat   389 DKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYESEGIEWEPVQYFNNKIICDLVEERHRGIISI 453

  Fly   481 LDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGF 545
            |||||:|||..||.:|||||.:|:.:|.|:...:.|....:|.:...||.|:||||||||...||
  Rat   454 LDEECIRPGPATDLSFLEKLEEKVGKHAHFQTRKLAGPKGRKRIGWLEFCLLHYAGEVTYCTKGF 518

  Fly   546 LDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAITQFRASLNNLMDILMCKEPSYI 610
            |:||||||:|.|||.|..:.|.|:|.||...||.:.|||.|..|||:.||::|::||:.||||||
  Rat   519 LEKNNDLLYRHLKEVLCSSKNSILRECFLVAELENRKRPPTVGTQFKNSLSSLLEILISKEPSYI 583

  Fly   611 RCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKG 675
            ||||||:.:..:.|:|.|:.||:|||||||:||||||||||||.||.||:|||||...|||::.|
  Rat   584 RCIKPNERKEPSKFDDFLISHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHG 648

  Fly   676 PGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQR 740
            |  |..||::|:|.:|:..:.|::|:||:|||:|||||.||||::..||::.:.|||.:||.:.|
  Rat   649 P--PGEGVERLIKYIGYQPQDYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVSRIQATYKGCLGR 711

  Fly   741 RKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMW 805
            |:|::.|.....::::.|..||::..|:|:.|...||.||||||.|:......||||:...::.:
  Rat   712 REYVRKRQAATKLEAHWRGVLARKEIKRRKWAVQIIRRFIKGFINRDKPLCPDNEEFLLLVRKNY 776

  Fly   806 LLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVF 870
            :|.|...:|..||||||...||..|.||.:|.|:...:|.|.|...::.::|...:.|.:...:|
  Rat   777 ILNLRYHVPKNVLDKSWLRPPGILENASNLLRRMCTRNLVRKYCRGISAERKAMMQQKAVTSGLF 841

  Fly   871 KGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLS 935
            :|||..||.|:|..|...|:.:   .::|..|....|||:::|.....|:||.|:|:|.|.:||:
  Rat   842 RGKKEGYAESLSQPFASSRLDE---GKINPKVLQLLGSEKIQYGVPVIKYDRKGFKARQRQLLLT 903

  Fly   936 NKAIYVLDGKTYKQKHRLPLDKIDFTLTNHNDDLMVIRI-PLDLKKDKGDLILIIPRIIEFSTYI 999
            .::.|:::....|||......: ..:.::..|.::||.: |.| |:.|||.||....|.|.:|.:
  Rat   904 LRSAYLVEFSKIKQKMEYSALR-GVSTSSLRDGILVIHVSPAD-KQQKGDTILQCEHIFEVATKL 966

  Fly  1000 IDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQTGAEPGVVRDK-GHLVII 1049
            ...:....:|.:| :.||:..|..|:.|.|..:||.|..|.:|| |.|.::
  Rat   967 AMLIKREHVVRVV-QGSLQFCVSPGREGTIVFETGEEDQVYKDKNGQLRVV 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	389/688 (57%)
		MYSc_Myo1	52..707	CDD:276829	365/655 (56%)
		Myosin_TH1	863..1035	CDD:283635	53/172 (31%)
Myo1h	XP_038946123.1	MYSc_Myo1	26..678	CDD:276829	365/655 (56%)
		Adgb_C_mid-like	<674..>752	CDD:412094	33/77 (43%)
		globin helix H	674..698	CDD:412094	15/23 (65%)
		IQ motif	722..740	CDD:412094	4/17 (24%)
		Myosin_TH1	834..1015	CDD:399188	60/186 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6135
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52678
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830