Protein Alignment Myo61F and Myh15

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001159682.1
• Gene: Myh15 / 667772
• MGIID: 3643515
• Length: 1925
• Species: Mus musculus
• Alignment Length: 1141
• Identity: 320/1141 - (28%)
• Similarity: 516/1141 - (45%)
• Gaps: 225/1141 - (19%)

  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:| .|.:|.:.:..|::|:...:||||.|...:::||||.||:|..:.:.||:.|...|:
Mouse    84 IEDLSML-LYLNEASVLHTLRRRYDHWMIYTYSGIFCVAINPYKWLPVYQKEVMAAYKRKRRSEV 147

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQF---IAACSGNQTTVEGVKDKL 165
            |||||||.:.||:.::.....|.::.:||||||||..:|.::|:   :||.|..:..:..::|::
Mouse   148 PPHIFAVANRAFQDMLRNGENQSIVFTGESGSGKTVNTKLIIQYFATMAAISEPKKKLGNLEDQI 212

  Fly   166 LKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHI 230
            :|.||:|||||||||.:|||||||||.:.|.|..:|.....:|..|.|||||||.|..||||:||
Mouse   213 VKMNPLLEAFGNAKTQKNDNSSRFGKLIRIHFGARGTLSFADIQIYFLEKSRVVYQQPGERNYHI 277

  Fly   231 FYQLLAGADEALLQELRLERALDT----YSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEE 291
            |||:|:|.     ||||....:.|    :...:.|: ..|..::||..|...::|:.|:.|..:|
Mouse   278 FYQILSGN-----QELRNMLLVSTNPSDFHICSCGV-VAVESLDDAKEFLATEKAIDVLGFLPDE 336

  Fly   292 QREIFGIVASILHLGNVGF--------TEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTI 348
            :...:.:|.:|:|.||:.|        .|.:|....:.      ||.|:|::||||...|.:..|
Mouse   337 KFGCYKLVGAIMHFGNLKFKRNLREEQLEADGTENADK------AAFLMGIHASELLKGLIYPRI 395

  Fly   349 DARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFE 413
            ....:.||...|.:...||..||::::|:|:|.|||.|:|..|.||.|   .:..:||||..|||
Mouse   396 KVGNEYVTRSQNLQQVTYAVGALSQSIYERMFQWLVARMNQVLDAKLT---SHFFVGILDTTGFE 457

  Fly   414 IFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGII 478
            |...||.||.||||.||||||.|.:.....||:|||:||::|:.::|..:...|....||..||.
Mouse   458 ILDYNSLEQLCINFTNEKLQQFFNQQLFILEQEEYRKEGLDWLSIDYGLDVQACIDFIEKPMGIF 522

  Fly   479 SILDEECLRPGEPTDKTFLEKLTQKLAQHHHY--VCHEKAPAHIKKIMLRDEFRLVHYAGEVTYS 541
            |||:|||:.| :.||:.|..||..     ||:  ..:.:.|...:| .....|.|.||||.|.|:
Mouse   523 SILEEECMLP-KATDQMFKTKLFD-----HHFGKSAYFQTPTSPEK-NFEVHFELAHYAGVVPYN 580

  Fly   542 VNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAITQF--------------- 591
            ::|::.||..||...:...|.|:.|.::.|.|.:..:..      :.:||
Mouse   581 ISGWIGKNKGLLNETVVALLQKSSNKVLANLFTKDIIAG------SASQFGEKTHKKGTSFHLIT 639

  Fly   592 ---RASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRR 653
               :.::|.||..|....|.::|||.||..:...|.:..|||.|::..|::|.:||....|....
Mouse   640 SLHKENINKLMTDLKSTAPHFVRCINPNKNKIPGVMDPFLVLQQLRCNGVLEGIRVCCEAFPSWM 704

  Fly   654 TYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDA 718
            .|:.|.:||..|:...:...|.....|| .::::..|..|...|:.|.||:|.: ...|...|:.
Mouse   705 LYDDFKQRYWILNPRIFSKSKFVSSRKA-TEEVLDFLEIDHPHYQCGVTKVFFK-AFILDQLEER 767

  Fly   719 YQEKKHEIAAIIQAHWKGLMQR---RKYLKLRAQVIIMQSYCR---------------------- 758
            ..||..::..:.||..:|.:.|   :|.|:.|..:.::|...|
Mouse   768 RDEKISKVFTLFQARARGKLMRITFQKILEERDALALIQENIRAFIAVKNCPWMGLFFKIKPLAK 832

  Fly   759 ------------------RKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGF--NEEFIANAKR 803
                              :|..:.:..:|.|...|..:.::   .:||.....  .:|.:||::.
Mouse   833 SVGAGEEIAGLKEECAQLQKALESSESQREELKTKQVSLVQ---EKNDLRLQLQAEQETLANSEE 894

  Fly   804 MW--LLRLAKELPTK-----------------------------------------VLDKSWPHA 825
            ..  |::...||..|                                         :|.||   .
Mouse   895 QCESLIKSKVELEVKIKELSRQVEEEEEINSELTARGRKLEDECSELKKEIYDLEAILAKS---E 956

  Fly   826 PGHC---EEASGILHRLHRLH-----LARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVS 882
            .|.|   .:...:...:|.|:     |:|:.:.....||:.|.:|.:..||:....|.|...:..
Mouse   957 KGKCAAEHKVRNLTEEVHSLNEEVSKLSRVVKDAQETQQQTQEQLHIEEEKLSNMSKANLKLAQQ 1021

  Fly   883 TWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTY 947
            ....|..:.:|...|:                    |.:|...|.:|. :.::.:....|:..
Mouse  1022 IDVLEGDLERERKARM--------------------KCEREKRKLQDE-LKMNQEGAENLESS-- 1063

  Fly   948 KQKHRLPLDKIDFTLTNHNDDLMVIRIPLDLKKDKGDLILIIPRIIEFSTYIIDTVGTASIVSIV 1012
            :||....|.|.:|.:...|.         .::.:|..:..:...:.|..|:|::.
Mouse  1064 RQKLAEQLRKKEFEMGQMNS---------KVENEKNQVSQLQKMVKELQTHILNL---------- 1109

  Fly  1013 DRNSLE-HNVVKGKGGVIDIQTGAEPGVVRDKGHLV 1047
             :..|| ...::.|             |.|:||.||
Mouse  1110 -KEELESERTIRAK-------------VEREKGDLV 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	252/715 (35%)
		MYSc_Myo1	52..707	CDD:276829	246/689 (36%)
		Myosin_TH1	863..1035	CDD:283635	25/172 (15%)
Myh15	NP_001159682.1	Myosin_N	31..69	CDD:280832
		Myosin_head	84..757	CDD:278492	250/702 (36%)
		MYSc_Myh15_mammals	96..757	CDD:276892	246/689 (36%)
		Myosin_tail_1	838..1914	CDD:279860	57/356 (16%)
		NBP1	<1004..>1136	CDD:285709	31/184 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910