Protein Alignment Myo61F and Myo3a

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_680779.4
• Gene: Myo3a / 667663
• MGIID: 2183924
• Length: 1613
• Species: Mus musculus
• Alignment Length: 1118
• Identity: 326/1118 - (29%)
• Similarity: 530/1118 - (47%)
• Gaps: 248/1118 - (22%)

  Fly     3 IEIKSLIFAIMDTKDYIDFNSQL-KMETGLHER--------DRA------GVQDF----VLLENY 48
            ||.|.:|.. ....::||.:..| ..|...|||        :|:      .|.|.    ||.||.
Mouse   290 IEGKDVILQ-KQLMEFIDIHQCLGSTEKARHERIHTKKGNLNRSLISSLKDVDDLATLDVLDENT 353

  Fly    49 QSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDN 113
            .||     :|:|.:..|.||.|:|.:||::||::.|.||:....:.|........||||||:.|.
Mouse   354 VSE-----HLEKCYSRDQIYIYVGDILIALNPFQSLGIYSTKLSRLYIGAKRTANPPHIFAMADL 413

  Fly   114 AFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG------VKDKLLKSNPVL 172
            .::|::..|..||::||||||:||||::..::|        |.||.|      :::|:|:.|.::
Mouse   414 GYQSMVTYNADQCIVISGESGAGKTESAHLLVQ--------QLTVLGKANNRTLQEKILQMNNLV 470

  Fly   173 EAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAG 237
            ||||||.|..||||||||||::::|...||.:|..|..||||||||:.|..||:||||||.:.||
Mouse   471 EAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNFHIFYYIYAG 535

  Fly   238 ADE----AL--LQELRLERAL--DTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQRE 294
            ..|    ||  |.|.:..|.|  |....:.|.:|.:..:    ..::.::|...||.||.|:...
Mouse   536 LAEKKKLALYKLPENKPPRYLQNDNLRTVQDMMNNSFYK----SQYELIEQCFKVIGFTMEQLGS 596

  Fly   295 IFGIVASILHLGNVGFTEVEGNAKVN-----SRDLVVTAARLLGVNASELEAALTHRTIDARGDV 354
            ::.::|:||::||:.|:.|....:::     :...:..:|.||.:.|.||:.|||...:..||:.
Mouse   597 VYSVLAAILNVGNIEFSSVATEYQMDKSYICNHTALENSASLLCIQADELQEALTSHCVVTRGET 661

  Fly   355 VTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVM--GILDIYGFEIFQK 417
            :..|...|.|...|||:||.:|.|||||:|..:| ||...:|..|.:..:  |||||:|||.|::
Mouse   662 IIRPNTVEKAADVRDAMAKTLYGRLFSWIVNCIN-SLLKHDTSPSGDEELNIGILDIFGFENFKR 725

  Fly   418 NSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILD 482
            |||||.|||..||::|..|.:.....||:||..|.::...:||.||:.:.::..:|..|::|:||
Mouse   726 NSFEQLCINIANEQIQYYFNQHVFAWEQNEYLNEDVDARVIEYEDNRPLLDMFLQKPMGLLSLLD 790

  Fly   483 EECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLD 547
            ||...| :.||:|.:||....|...:.:        ..|::.|  .|.:.||||:|.||.:|||.
Mouse   791 EESRFP-KATDQTLIEKFEDNLKSQYFW--------RPKRMEL--SFGIHHYAGKVLYSASGFLA 844

  Fly   548 KNNDLLFRDLKETLSKAGNGIVRNCF-------------------------PEKELRSLK----- 582
            ||.|....|:...|..:.|.::|...                         .||.....|
Mouse   845 KNRDTFPTDIVLLLRSSENSVIRQLVNHPLTKTGNLPLSKTKNIVNYQMWNSEKSTNLTKGETRD 909

  Fly   583 -----------RPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYL 636
                       :.:|..:.||.||.:|:..::..:|.::||||||:.:.|..::.|.||.|::..
Mouse   910 VTCHACETTNVKTQTVSSYFRYSLMDLLSKMVVGQPHFVRCIKPNNERQARKYDKEKVLLQLRCT 974

  Fly   637 GLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGP------------KAGVQQLVKD 689
            |::|..|:||.|:::|..:..|::||..|.      ||....|            |||:
Mouse   975 GILETARIRRLGYSHRILFANFIKRYYILC------YKSSEEPPVSPDTCAAILEKAGL------ 1027

  Fly   690 LGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEI--AAIIQAHWKGLMQRRKYLKL----RA 748
                 :.:.:|:||:|:::    :..|.....:|...  ..:|||..:..:..|:|.:|    ::
Mouse  1028 -----DNWALGKTKVFLKY----YHVEQLNLMRKEATNKLVLIQASVRAFLGARRYQELQQKRKS 1083

  Fly   749 QVIIMQSYCRRKLAQQAAKK----RREAADKIRA------FIKGFITRNDAPNGFNEEFIANAKR 803
            ..:|:||..||.|.::..|:    :..|...|||      :.|.|.|:.::   |.::...||
Mouse  1084 SAVIIQSAARRHLLRKHGKETSNVKSAAGRSIRAKDQEFDYKKNFETKRES---FVKKQTENA-- 1143

  Fly   804 MWLLRLAKELPTKVLDKSWPH----------APGHCE-EASGILHRLHRLH----LARIYR---- 849
                     :||...:.|.|:          ||...| :|:.:.....|.|    ::.:|.
Mouse  1144 ---------VPTNESNTSTPNNKESPSAGKTAPFRAESKATNVESNNRRYHTQKKMSNVYAEGQN 1199

  Fly   850 ----------LKLTPQQKRQFELKVLAEKVFKGKKNN-YASSVSTWFQEDRIPKEHIQRVNDFVA 903
                      .:::|:||...:|:. :.|:.|.:|.: ...|...|:.|
Mouse  1200 QELYIVEDTWAEVSPRQKYVQDLEE-SRKMRKEEKGDAVIQSYCQWYTE---------------- 1247

  Fly   904 STFGSEQLKYQSFCTK----FDRHG----------YKSRDRFILLSNKAIYV-LDGKTYKQKHRL 953
               ||...:.::.|.:    ::|..          |..:.....||.|::|. .|||  :::|::
Mouse  1248 ---GSNFEESKATCLEGRETWERTSCPGLWLTEEIYLRKTLDPTLSQKSVYQNADGK--EKEHKV 1307

  Fly   954 -------PLDKID 959
                   ||..::
Mouse  1308 SVVTQNAPLGNLE 1320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	245/728 (34%)
		Myosin_TH1	863..1049	CDD:461801	21/120 (18%)
Myo3a	NP_680779.4	Protein Kinases, catalytic domain	2..287	CDD:473864
		MYSc_Myo3	352..1040	CDD:276830	248/733 (34%)
		MBD_Myo3a	1407..1454	CDD:439318