DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo1c

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_038942736.1	Gene:	Myo1c / 65261	RGDID:	620443	Length:	1063	Species:	Rattus norvegicus

Alignment Length:	1043	Identity:	540/1043 - (51%)
Similarity:	714/1043 - (68%)	Gaps:	36/1043 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYT 88
            ::.||:.|..|||.||||||||||:.||.|||.||::||:|:|||||||.||:|||||:.|.|||
  Rat    33 RVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYT 97

  Fly    89 DDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG 153
            ..|::.||...|||:|||:|||.|..:|:|..|.|.|.|:||||||:|||||:|::|||.|....
  Rat    98 RQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCP 162

  Fly   154 NQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRV 218
            .......|:|:||:|||||||||||||.|||||||||||||:||||||||:||:||:||||||||
  Rat   163 APERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRV 227

  Fly   219 VAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALT 283
            |.|..||||||:|||||.|.:|..|:.|.|||...:|.||..|....|:.|||...:|.|::||:
  Rat   228 VHQNHGERNFHVFYQLLEGGEEEALRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALS 292

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGF-TEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRT 347
            |||||::|..::..||||:|||||:.| .:.:.||:|.:.:.:....|||||..:.|..|||||.
  Rat   293 VIDFTEDEVEDLLSIVASVLHLGNIHFAADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRK 357

  Fly   348 IDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRA---SRNNVMGILDI 409
            |.|:|:.:.||||.|.|.|||||||||||.|.|:|||:::|.||.:|:..:   ....|:|:|||
  Rat   358 IIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDI 422

  Fly   410 YGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKH 474
            ||||:||.|||||||||:||||||||||||||||||:||..|||.|.||:||:||:||:|:|||.
  Rat   423 YGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKF 487

  Fly   475 KGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVT 539
            ||||||||||||||||.||.||||||...:..|.|::.|:.|....:|.:.|.||||:|||||||
  Rat   488 KGIISILDEECLRPGEATDLTFLEKLEDTIKHHPHFLTHKLADQKTRKSLDRGEFRLLHYAGEVT 552

  Fly   540 YSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAITQFRASLNNLMDILMC 604
            |||.||||||||||||:||||:..:.|.|:..||.:.||...|||||..|||:.||..|::||..
  Rat   553 YSVTGFLDKNNDLLFRNLKETMCSSTNPIMAQCFDKSELSDKKRPETVATQFKMSLLQLVEILRS 617

  Fly   605 KEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKST 669
            |||:|||||||||.:....|::.|:.|||||||||||||||||||||||.||.||:|||||...|
  Rat   618 KEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPET 682

  Fly   670 WPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHW 734
            ||.:  .|.|:.||..||:.||:..|:|::|.||:|||:|:|||.|||:.:.::..:|..|||.|
  Rat   683 WPVW--TGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAW 745

  Fly   735 KGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAP----NGFNE 795
            :|...|:|:|:::...|.:||:.|..|.::.|.||:.||..||..|:|||.|: ||    |.|
  Rat   746 RGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRH-APRCPENAF-- 807

  Fly   796 EFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQF 860
             |:.:.:..:||.|.::||..|||.|||..|....|||.:|..|...::...|...::|:.|:|.
  Rat   808 -FLDHVRTSFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQL 871

  Fly   861 ELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGY 925
            :.|.:|.::|||||:||..||...|...|:..|.|   :..|....|||.::|.....|:||.||
  Rat   872 QQKAVASEIFKGKKDNYPQSVPRLFISTRLGTEEI---SPRVLQALGSEPIQYAVPVVKYDRKGY 933

  Fly   926 KSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDF------TLTNHNDDLMVIRIPLDLKKDKGD 984
            |.|.|.:||:..|:.:::....||       :||:      ::::.:|.|.|:.:..:..|.|||
  Rat   934 KPRSRQLLLTPSAVVIVEDAKVKQ-------RIDYANLTGISVSSLSDSLFVLHVQREDSKQKGD 991

  Fly   985 LILIIPRIIEFSTYIIDTVGTASIVSIVDRN--SLEHNVVKGKGGVIDIQTGAEPGVVRDK-GHL 1046
            ::|....:||..|   .|..:|..|:.::.|  |:......|:.|:||..:|:|..:.:.| |||
  Rat   992 VVLQSDHVIETLT---KTALSADRVNNININQGSITFAGGPGRDGIIDFTSGSELLITKAKNGHL 1053

  Fly  1047 VII 1049
            .::
  Rat  1054 AVV 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	424/691 (61%)
		MYSc_Myo1	52..707	CDD:276829	400/658 (61%)
		Myosin_TH1	863..1035	CDD:283635	55/179 (31%)
Myo1c	XP_038942736.1	MYSc_Myo1	62..718	CDD:276829	400/657 (61%)
		IQ	756..776	CDD:197470	5/19 (26%)
		Myosin_TH1	874..1055	CDD:399188	61/193 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	812	1.000	Domainoid score	I67
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32046
Inparanoid	1	1.050	1010	1.000	Inparanoid score	I273
OMA	1	1.010	-	-		QHG52678
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		oto95747
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2957
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880