DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo61F and MYO1G

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_149043.2	Gene:	MYO1G / 64005	HGNCID:	13880	Length:	1018	Species:	Homo sapiens

Alignment Length:	990	Identity:	395/990 - (39%)
Similarity:	563/990 - (56%)	Gaps:	90/990 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            |..|||||:....|: |:.||:.||::..||||||:||:|||||::||:|..:.:..|:.:..||
Human    10 GKPDFVLLDQVTMED-FMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELYE 73

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACS--GNQTTVEGVKDKL 165
            .|||::||.:.|::::...:|..|::||||||:|||||||.::|:|||.:  ..:..||.|||.|
Human    74 RPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVL 138

  Fly   166 LKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHI 230
            |||..||||||||:||||.|||||||||||.|||||.||||:|.:||||||||:.|..||||||.
Human   139 LKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHA 203

  Fly   231 FYQLLAGADEALLQELRLER--ALDTYSYLTDGLNGTVTRINDAD--SFKQVQQALTVIDFTKEE 291
            |||||.|:::..|.||.|||  |:..:::...|||.||....|:|  |.:.|.:|:.||.|:.||
Human   204 FYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALDSDEQSHQAVTEAMRVIGFSPEE 268

  Fly   292 QREIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAARLLGVNASELEA--------ALTHRTI 348
            ...:..|:|:||||||:.|.|.| ...:....|.|....|:. :.:||.|        :|..||:
Human   269 VESVHRILAAILHLGNIEFVETE-EGGLQKEGLAVAEEALVD-HVAELTATPRDLVLRSLLARTV 331

  Fly   349 DARG-DVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAK---ETRASRNNVMGILDI 409
            .:.| :::........|.|||||.|||||.|||.|:|.|:|..::.:   ..|..::.|:|:|||
Human   332 ASGGRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIGVLDI 396

  Fly   410 YGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKH 474
            ||||:|..|||||||||:||||||||||:|.||.||:||.||||.|..||||:|..|.:|:|..|
Human   397 YGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIVDLVERPH 461

  Fly   475 KGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVT 539
            :||:::|||.|...|..||:.||:.|......|.||...:..|.. |.:....:||:.||||:||
Human   462 RGILAVLDEACSSAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTD-KTMEFGRDFRIKHYAGDVT 525

  Fly   540 YSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKE---LRSLKRPETAITQFRASLNNLMDI 601
            |||.||:|||.|.||:|.|..|..:.:..:|..:|:.:   ....|||.||.|.|:.|:..|::.
Human   526 YSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVEN 590

  Fly   602 LMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLS 666
            |..|||.|:||||||:.:.|...::....|||.||||:||:||||||||.|:.|..||.|||...
Human   591 LASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYKMTC 655

  Fly   667 KSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQ 731
            :.||||:. .|..||.|..|::..|...: ...|.:|||||.||||...|.:.......|..::|
Human   656 EYTWPNHL-LGSDKAAVSALLEQHGLQGD-VAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQ 718

  Fly   732 AHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEE 796
            ..|:|.:.|.:..:|||...||:.:.|.|:....|:.:|.
Human   719 KAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRR------------------------- 758

  Fly   797 FIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFE 861
                      .:.|::.|....|..||..|...:......|.|.....||.....:.|....|.:
Human   759 ----------FQAARQPPLYGRDLVWPLPPAVLQPFQDTCHALFCRWRARQLVKNIPPSDMPQIK 813

  Fly   862 LKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDF-VASTFGSEQLK------------Y 913
            .||.|....:|.:.::... ..|      .::::....|. .||:..:::||            :
Human   814 AKVAAMGALQGLRQDWGCR-RAW------ARDYLSSATDNPTASSLFAQRLKTLQDKDGFGAVLF 871

  Fly   914 QSFCTKFDRHGYKSRDRFILLSNKAIYVLD-GKTYKQKHRLPLDKI-DFTLTNHNDDLMVIRIPL 976
            .|...|.:|. :|.|:|.:||:::.:|.|| .:.|:....:||:.: ..::|:..|.|:|:.
Human   872 SSHVRKVNRF-HKIRNRALLLTDQHLYKLDPDRQYRVMRAVPLEAVTGLSVTSGGDQLVVLH--- 932

  Fly   977 DLKKDKGDLILIIPR 991
              .:.:.||::.:.|
Human   933 --ARGQDDLVVCLHR 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	338/702 (48%)
		MYSc_Myo1	52..707	CDD:276829	324/675 (48%)
		Myosin_TH1	863..1035	CDD:283635	31/144 (22%)
MYO1G	NP_149043.2	MYSc	4..706	CDD:214580	338/701 (48%)
		MYSc_Myo1	23..694	CDD:276829	325/676 (48%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	584..606		11/21 (52%)
		Myosin_TH1	815..980	CDD:283635	31/144 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720