Protein Alignment Myo61F and MYH7B

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_047296292.1
• Gene: MYH7B / 57644
• HGNCID: 15906
• Length: 2033
• Species: Homo sapiens
• Alignment Length: 1044
• Identity: 312/1044 - (29%)
• Similarity: 492/1044 - (47%)
• Gaps: 206/1044 - (19%)

  Fly    42 FVLLEN-----YQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFY 101
            |.|||:     :.:|.:.:.||::|:...:||||.|...:::||||.||:||...|.||:.|...
Human   125 FDLLEDMAMMTHLNEASVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTASVVAAYKGKRRS 189

  Fly   102 EMPPHIFAVTDNAFRSLIEENRGQCVLISG-----ESGSGKTEASKKV---LQFIAACSGNQTTV 158
            :.||||:||.|||:..:: .::|:  |.|.     :.|.|:....:.|   .||:|..:|.  |:
Human   190 DSPPHIYAVADNAYNDML-RSKGR--LDSSPTADPDLGPGRPLPRQPVHADHQFLATKTGG--TL 249

  Fly   159 EGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMG 223
            |   |:::::||.:||||||||.||||||||||::.|.|...|.....:|.:||||||||:.|:.
Human   250 E---DQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADIDSYLLEKSRVIFQLP 311

  Fly   224 GERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFT 288
            |||::|::||:|:|....|...|.|......|.:.:.|:. ||..:||.:.......|:.::.|:
Human   312 GERSYHVYYQILSGRKPELQDMLLLSMNPYDYHFCSQGVI-TVDNMNDGEELIATDHAMDILGFS 375

  Fly   289 KEEQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDAR 351
            .:|:...:.||.::||.||:.|.:.  |..|:.:..:....||.|:||::.:|...|.|..:...
Human   376 VDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSGDLLKGLLHPRVRVG 440

  Fly   352 GDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQ 416
            .:.||...:.|..::|..|||||.|||||.|||.|:|   |..:|:..|...:|:|||.|||||:
Human   441 NEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRIN---QTLDTKLPRQFFIGVLDIAGFEIFE 502

  Fly   417 KNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVICNLIEEKHK----- 475
            .|||||.||||.||||||.|.:.....||:||:||||:|:.::: .|.:...:|||:..:
Human   503 FNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKVRRLRLSD 567

  Fly   476 --------------GIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLR 526
                          ||:|||:|||:.| :.:|.:|..||..   .|.....:.:.|...||...:
Human   568 VGGPHSYSFCSQPLGILSILEEECMFP-KASDASFRAKLYD---NHAGKSPNFQQPRPDKKRKYQ 628

  Fly   527 DEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCF----------PEKELRSL 581
            ..|.:|||||.|.||:.|:|:||.|.|...:.....|:.|.::...:          |.|.....
Human   629 AHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENYAGSCSTEPPKSGVKE 693

  Fly   582 KRPETAITQ-----FRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMEN 641
            ||.:.|..|     .:.:||.||..|...:|.::|||.||:.:|..|.:..|||||::..|::|.
Human   694 KRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDAFLVLHQLRCNGVLEG 758

  Fly   642 LRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFI 706
            :|:.|.||..|..|..|.:||:.|:.|..|:.......|| .::|:..|..|..:|:.|.||:..
Human   759 IRICRQGFPNRLLYTDFRQRYRILNPSAIPDDTFMDSRKA-TEKLLGSLDLDHTQYQFGHTKVGA 822

  Fly   707 RW-----------------------------PRTLFDT------EDAYQEKKHEIAAIIQAHWKG 736
            .|                             |:..|..      |:...::..::..::||..:|
Human   823 LWDQGWPWLWRSHWAGFMRMVGGYPGCLPLRPQVFFKAGLLGVLEELRDQRLAKVLTLLQARSRG 887

  Fly   737 LMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANA 801
            .:.|.:|.:|..                    .|:|...|:..|:.|                ||
Human   888 RLMRLEYQRLLG--------------------GRDALFTIQWNIRAF----------------NA 916

  Fly   802 KRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLK-LTPQQKRQFELKVL 865
            .:.|               ||                     :...:::| |....:.:.||..|
Human   917 VKNW---------------SW---------------------MKLFFKMKPLLRSAQAEEELAAL 945

  Fly   866 AEKVFKGKKNNYASSVSTWFQEDRIPKEHI---QRVNDFVASTFGSEQLKYQSFCTKFDRHGYKS 927
            ..:: :|.:...|::.:   :...:.:.|:   |..|| :|....:||          |......
Human   946 RAEL-RGLRGALAAAEA---KRQELEETHVSITQEKND-LALQLQAEQ----------DNLADAE 995

  Fly   928 RDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHNDDLMVIRIPL-----DLKKDKGDLIL 987
            ....:|:.:|.  .|:||..:...||..::      ..|.||...|..|     :||||..||.|
Human   996 ERCHLLIKSKV--QLEGKVKELSERLEDEE------EVNADLAARRRKLEDECTELKKDIDDLEL 1052

  Fly   988 IIPR 991
            .:.:
Human  1053 TLAK 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	253/699 (36%)
		Myosin_TH1	863..1049	CDD:461801	30/137 (22%)
MYH7B	XP_047296292.1	Myosin_N	72..117	CDD:460670
		Motor_domain	140..820	CDD:473979	252/696 (36%)
		Myosin_tail_1	939..2016	CDD:460256	32/141 (23%)