Protein Alignment Myo61F and myo15ab

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_021331574.1
• Gene: myo15ab / 570113
• ZFINID: ZDB-GENE-090312-149
• Length: 4355
• Species: Danio rerio
• Alignment Length: 1062
• Identity: 345/1062 - (32%)
• Similarity: 527/1062 - (49%)
• Gaps: 200/1062 - (18%)

  Fly    33 ERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRN 97
            :|...|.:|...:|.. :|.|.:.|||.||.::|||||||.:|:|||||:...||..|.|..|..
Zfish  1955 KRKGDGTEDMTQMEQL-TEPAVLINLKIRFDQELIYTYIGSILVSVNPYQLFNIYGTDMVLQYEG 2018

  Fly    98 KHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVK 162
            ....:.|||:||:.:.|:.::::..:.||::||||||||||||:|.||:::.|....:...:.:
Zfish  2019 HAMADNPPHLFAIANVAYTTMMDIKQNQCIIISGESGSGKTEATKLVLRYLTAIHHKRNITQQI- 2082

  Fly   163 DKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERN 227
             ::|::.|:||:||||||.||||||||||:::| |..:|...|.....|||||||:|.|...|||
Zfish  2083 -EILEATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEEGVISGAITSQYLLEKSRIVFQAKDERN 2145

  Fly   228 FHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQ 292
            :||||::|||......:...|:.| :||.||..|.|..:|..:|.:.|:::|.|:.::.|:.|:|
Zfish  2146 YHIFYEMLAGLPSHTKRAFYLQEA-ETYYYLNQGGNCGITGKDDGEDFRRLQSAMDILHFSTEDQ 2209

  Fly   293 REIFGIVASILHLGNVGF----TEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGD 353
            ..||.:::||||||||.|    |||:..|.|.|...:...|.||.::...|:.|:|.:..:|..:
Zfish  2210 SSIFRVLSSILHLGNVFFHRVETEVQETAGVVSTQEIRAVADLLQISPEGLQKAITFKVTEAMRE 2274

  Fly   354 VVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKN 418
            .:.:||:.|.|:.||||:||.:|..||:||..|:|..:..:....|    :.:|||||||....|
Zfish  2275 KIYTPLSVESAVDARDAVAKILYSLLFNWLTDRINGRVYPRNEALS----ISLLDIYGFESLVFN 2335

  Fly   419 SFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDE 483
            ||||.|||:.||.||..|.::..|.||:||.||.|.|..:.:.||:...:||..|..|::.|||:
Zfish  2336 SFEQLCINYANETLQFFFSKIIFKQEQEEYIREQINWKELTFTDNQACIDLISAKPHGLLRILDD 2400

  Fly   484 ECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDK 548
            :...| :.||.|||:|.      |:|   |...|.:.|..|...||.:.||||.|||.|:.||||
Zfish  2401 QSCFP-QATDNTFLQKC------HYH---HGNNPLYSKPKMPLPEFTVYHYAGRVTYQVHKFLDK 2455

  Fly   549 NNDLLFRDLKETLSKAGNGIVRNCF-PEKELRSLKR--------------PETAITQFRASLNNL 598
            |.|.:.:::.:...::.|..|.|.| ...|:.:.::              |.|...:|:.||..|
Zfish  2456 NFDQVRQEVLDLFMQSQNRTVSNLFIKHSEMLNQQKGAMNRSSTVTRRYQPSTVAAKFQQSLQEL 2520

  Fly   599 MDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYK 663
            :|.:....|.::||||||:.:...:|:.|||..|::|.|:::.:|:|:.|:..|..:..||.|||
Zfish  2521 LDKMERCNPFFVRCIKPNNNKEPGIFDPELVATQLRYSGILDTIRIRKEGYPIRVPFHKFLNRYK 2585

  Fly   664 SLSKSTWPNYKGPGGPKAG---VQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQ--EKK 723
            :|.....|      .|..|   |..|.|....::..|:||.:|||::        |:.||  |.|
Zfish  2586 ALLGMKKP------PPSDGDNCVMMLTKLCPINKGDYQVGVSKLFLK--------EEVYQLLESK 2636

  Fly   724 HE----IAAI-IQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGF 783
            .:    |||: :|.:.:....|||:||.|..:..:|::|:..:|:|...:.|....:.||.|:
Zfish  2637 RDRVMHIAALTLQRYVRMFFARRKFLKFRLTMTHLQAHCKGFMARQRFLRMRINLIRHRAMIR-- 2699

  Fly   784 ITRNDAPNGFNEEFIANAKR-----MWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLH 843
                         .|.|.||     :.|.|.|:|
Zfish  2700 -------------LIVNRKRYIRINVLLARRAEE------------------------------- 2720

  Fly   844 LARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGS 908
                        ::|:.||:.::.:|.     |....|        ||.|    :...:.:|.|.
Zfish  2721 ------------ERRRLELERISREVV-----NVTQLV--------IPAE----LGGLLQATAGG 2756

  Fly   909 EQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLT----NHNDDL 969
            .           :||.    |...|:....|......|      ||||..:..:|    .|..:|
Zfish  2757 R-----------ERHS----DCLALVQAPRIQTDPQLT------LPLDINNHLMTKYIRTHFREL 2800

  Fly   970 M--VIRIPL---------DLKKDKGDLILIIPRIIE-----------FSTYII----------DT 1002
            :  ::..||         |||:|..|:.::|.|.:.           |..|||          |.
Zfish  2801 LFGMLTAPLENSLTRLEDDLKQDAVDVFILILRFMGDPNLNGAQENLFGNYIIQRGLATPPIRDE 2865

  Fly  1003 VGTASIVSIVDRNSLEHNVVKG 1024
            : .|.|.:.|.||....|..:|
Zfish  2866 I-LAQIANQVWRNENSRNAERG 2886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	270/708 (38%)
		MYSc_Myo1	52..707	CDD:276829	264/676 (39%)
		Myosin_TH1	863..1035	CDD:283635	42/198 (21%)
myo15ab	XP_021331574.1	Atrophin-1	<546..799	CDD:331285
		Atrophin-1	<719..1317	CDD:331285
		FtsK	<1119..>1705	CDD:332908
		Motor_domain	1974..2626	CDD:328930	264/675 (39%)
		MyTH4	2808..2955	CDD:214535	21/80 (26%)
		SH3	3686..3765	CDD:327375
		MyTH4	3875..4028	CDD:214535
		FERM_B-lobe	4137..4234	CDD:271216
		FERM_C_MyoXV	4240..4341	CDD:270022

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910