Protein Alignment Myo61F and myo5ab

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_009296049.3
• Gene: myo5ab / 565267
• ZFINID: ZDB-GENE-050411-72
• Length: 1800
• Species: Danio rerio
• Alignment Length: 1037
• Identity: 327/1037 - (31%)
• Similarity: 521/1037 - (50%)
• Gaps: 155/1037 - (14%)

  Fly    16 KDYIDFNSQLKMETG----LHERD-RAGVQDFVLLENYQSEEAFIGNLKKRFQED-LIYTYIGQV 74
            :|..:...:|.:::|    |...| ..|..|...| :|..|.|.:.||:.||.:. |||||.|.:
Zfish    43 EDETELEYKLDLKSGVLPPLRNPDILVGENDLTAL-SYLHEPAVLHNLRVRFTDSKLIYTYCGII 106

  Fly    75 LISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTE 139
            |:::|||:.||||..|.:.||..::..:|.||||||::.|::.:..:.:.|.:::|||||:|||.
Zfish   107 LVAINPYESLPIYGSDIINAYSGQNMGDMDPHIFAVSEEAYKQMARDEKNQSIIVSGESGAGKTV 171

  Fly   140 ASKKVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPI 204
            ::|..:::.|..|.:.... .|::|:|.|||::||||||||.|||||||||||::|.||.|...|
Zfish   172 SAKYAMRYFATVSESSDDA-SVEEKVLASNPIMEAFGNAKTTRNDNSSRFGKYIEIGFDRKHHII 235

  Fly   205 GGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRI 269
            |.|:..|||||||||.|...|||:||||||.|.|.....:.|:|..| |.:.|...|.:..:..:
Zfish   236 GANMRTYLLEKSRVVFQASEERNYHIFYQLCACAHLPEFKPLKLGSA-DDFPYTNQGGSPVIVGV 299

  Fly   270 NDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAKVNSRD---LVVTAARL 331
            ||....:..::|.:::..|:..|..:|.|:::|||||||...| .|::..:..|   .:.....|
Zfish   300 NDLKEMQATRKAFSLLGITEAHQMGLFQILSAILHLGNVEVKE-RGSSSCSISDENGHLDMFCDL 363

  Fly   332 LGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKET 396
            ..|:...:...|.|:.:....:.:..|:.:..|:..||||||.:|.:||||:|.::|   :|..|
Zfish   364 TEVSNESMAHWLCHKKLKTATETLNKPVTRLEAVNGRDALAKHIYAKLFSWIVSQVN---KALST 425

  Fly   397 RASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYF 461
            .:..::.:|:|||||||.|:.|||||||||:.||||||.|.....|.||:||.:|.|.|..::::
Zfish   426 SSKPHSFIGVLDIYGFETFELNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFY 490

  Fly   462 DNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLR 526
            ||:...||||.| .|::.:|||||..| :.:|.::.:||         |..|.|..:|.:|..:.
Zfish   491 DNQPCINLIEAK-MGLLDLLDEECTMP-KGSDDSWAQKL---------YNTHLKKSSHFEKPRMS 544

  Fly   527 DE-FRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAIT- 589
            :: |.::|:|.:|.|..:|||:||.|.:..:....|..:...::...|.::|  |...|.|..:
Zfish   545 NKAFIILHFADKVEYQCDGFLEKNKDTVNEEQINVLKASKFSLLLELFQDEE--SPAAPNTTASS 607

  Fly   590 ---------------------QFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQV 633
                                 |||.||:.||:.|....|.|:|||||||::...:.:....:.|:
Zfish   608 GRAKFGRSTQSFREHKKSVGLQFRNSLHLLMETLNATTPHYVRCIKPNDVKAPFMMDPHRAVQQL 672

  Fly   634 KYLGLMENLRVRRAGFAYRRTYELFLERYKSL--SKSTWPNYKGPGGPKAGVQQLVKDLGWDEEK 696
            :..|::|.:|:..|||..|.||:.|..||:.|  .|....:      .|...|.:::.|..:::|
Zfish   673 RACGVLETIRISAAGFPSRWTYQEFFSRYQVLMTKKEILLD------RKLTCQSVLERLVQNKDK 731

  Fly   697 YRVGETKLFIRWPRTLFDTEDAYQEK----KHEIAAI-IQAHWKGLMQRRKYLKLRAQVIIMQSY 756
            |:.|:||:|.|..:.      ||.||    |...|.| ||...:..:.|:|||::|...|.:|.|
Zfish   732 YQFGKTKIFFRAGQV------AYLEKLRADKLRTACIHIQKTIRCWLARKKYLRIRQAAITLQKY 790

  Fly   757 CRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLLR-------LAKELP 814
            .|...|:...|..|    :.||.:               .|..|. |||..|       .|..|.
Zfish   791 TRGHQARCLCKTLR----RTRAAV---------------VFQKNT-RMWAARRQYLRQKTAAVLI 835

  Fly   815 TKVLDKSWPHAPGH----------CEEASGILHRLHRLHLAR----------IY-----RLKLTP 854
            .::|       .|:          ||..:.::.|..|..|||          :|     |..|..
Zfish   836 QRIL-------RGYTARLEYKRLVCEHKALLIQRWVRGFLARWRYRRIKRAVVYLQCCVRRMLAR 893

  Fly   855 QQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTK 919
            ::.:  :||:.|..|...||.||.........:.::.::|  :.|..::...|:
Zfish   894 RELK--KLKIEARSVEHYKKLNYGMENKIMQLQRKLDEQH--KENRELSEQIGA----------- 943

  Fly   920 FDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHNDDLMVIRIPLDLKKD 981
            .:.|.....::.    :..:..|.....:.:||..|      :|:..::|.::|..|:..|:
Zfish   944 IESHSVVELEKL----HVQLKTLQEAEEEARHREDL------VTSLQEELELVRRELEKNKE 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	252/683 (37%)
		Myosin_TH1	863..1049	CDD:461801	20/119 (17%)
myo5ab	XP_009296049.3	None