DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo61F and MYO5C

DIOPT Version :9

Sequence 1:NP_476934.2 Gene:Myo61F / 38153 FlyBaseID:FBgn0010246 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_061198.2 Gene:MYO5C / 55930 HGNCID:7604 Length:1742 Species:Homo sapiens


Alignment Length:1019 Identity:329/1019 - (32%)
Similarity:522/1019 - (51%) Gaps:121/1019 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQED-LIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFY 101
            |..|...| :|..|.|.:.||:.||.|. |||||.|.:|:::|||||||||.|..:.||..::..
Human    68 GENDLTAL-SYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMG 131

  Fly   102 EMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLL 166
            :|.||||||.:.|::.:...||.|.:::|||||:|||.:::..:::.|..|.:.:... |:||:|
Human   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAH-VEDKVL 195

  Fly   167 KSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIF 231
            .|||:.||.|||||.|||||||||||.:|.||.:...||.|:..|||||||||.|...|||:|||
Human   196 ASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIF 260

  Fly   232 YQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIF 296
            |||.|.|.::..:.|:|..| :.::|...|.|..:..:||.....:.|:..|::.|.::.|.::|
Human   261 YQLCASAQQSEFKHLKLGSA-EEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVF 324

  Fly   297 GIVASILHLGNVGFTEVEGN--AKVNSRDL-VVTAARLLGVNASELEAALTHRTIDARGDVVTSP 358
            .|:|:|||||||..|.| ||  :.|:..|. :.....|||:.:..:...|.:|.|....:.|..|
Human   325 KILAAILHLGNVQITAV-GNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKP 388

  Fly   359 LNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQF 423
            :.:..|:.|||||||.:|..||.::|:|:|   ||.:....::..:|:|||||||.|..||||||
Human   389 MTRPQAVNARDALAKKIYAHLFDFIVERIN---QALQFSGKQHTFIGVLDIYGFETFDVNSFEQF 450

  Fly   424 CINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRP 488
            |||:.||||||.|.....|.||:||.:|.|.|..::::||:.:.:|||.| .||:.:||||||.|
Human   451 CINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILELLDEECLLP 514

  Fly   489 GEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLL 553
             ..||:.:|:||      ::::|  .:.|...|..|....|.:.|:|.:|.|...|||:||.|.:
Human   515 -HGTDENWLQKL------YNNFV--NRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTV 570

  Fly   554 FRDLKETLSKAGNGIVRNCFPE--------------KELRSLKRPE------TAITQFRASLNNL 598
            :..|.|.|..:...:..|.|.|              |..:.:.:|.      |..::||:||..|
Human   571 YDMLVEILRASKFHLCANFFQENPTPPSPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLL 635

  Fly   599 MDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYK 663
            |:.|....|.|:|||||||.:....|:.:.::.|::..|::|.:|:....:..|.||..|..||.
Human   636 METLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYG 700

  Fly   664 SLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAA 728
            .|......::   ...|...:.::..|..|..:|:.|:||:|.|..:..: .|....:|..:...
Human   701 ILMTKQELSF---SDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAY-LEKLRLDKLRQSCV 761

  Fly   729 IIQAHWKGLMQRRKYLKLRAQVIIMQSYCR-----RKLAQQAAKKRREAADKIRAFIKGFITRN- 787
            ::|.|.:|.:||:|:|:.|...:|:|.|.|     ||.....|.|...||..|:...:|::.|: 
Human   762 MVQKHMRGWLQRKKFLRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSL 826

  Fly   788 --------DAPNGFNEEFIANAK-----------------RMWLLR-----------------LA 810
                    .....::..|:|..:                 |.||.|                 ..
Human   827 YQLIRMATITMQAYSRGFLARRRYRKMLEEHKAVILQKYARAWLARRRFQSIRRFVLNIQLTYRV 891

  Fly   811 KELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKN 875
            :.|..|:.|::        :|..|::.:|..|...|...::...:.:.:.|......:.::.|..
Human   892 QRLQKKLEDQN--------KENHGLVEKLTSLAALRAGDVEKIQKLEAELEKAATHRRNYEEKGK 948

  Fly   876 NYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIY 940
            .|..:|     |:::.|  :|:.|..:.:.....|||.|.          |:.:....:.|....
Human   949 RYRDAV-----EEKLAK--LQKHNSELETQKEQIQLKLQE----------KTEELKEKMDNLTKQ 996

  Fly   941 VLDGKTYKQKHRLPLDKIDFTLTNHNDDLMVIRIPLDLK--KDK 982
            :.|....:::.|:.|:| .|.|...:.:..:..:..::|  ||:
Human   997 LFDDVQKEERQRMLLEK-SFELKTQDYEKQIQSLKEEIKALKDE 1039

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo61FNP_476934.2 MYSc 32..720 CDD:214580 270/705 (38%)
MYSc_Myo1 52..707 CDD:276829 263/678 (39%)
Myosin_TH1 863..1035 CDD:283635 22/122 (18%)
MYO5CNP_061198.2 Myosin_N 12..48 CDD:280832
MYSc 62..752 CDD:214580 270/704 (38%)
MYSc_Myo5 81..741 CDD:276831 263/678 (39%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 632..654 11/21 (52%)
IQ 810..828 CDD:197470 5/17 (29%)
COG1340 890..1150 CDD:224259 31/176 (18%)
P-loop_NTPase <910..>1163 CDD:304359 26/148 (18%)
GBP_C <927..1030 CDD:303769 20/120 (17%)
coiled coil 997..1010 CDD:293879 2/12 (17%)
coiled coil 1019..1030 CDD:293879 0/10 (0%)
Rab5-bind 1020..1345 CDD:286404 3/20 (15%)
DUF3585 1160..1326 CDD:304905
Myo5c_CBD 1369..1736 CDD:271260
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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