DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo61F and LOC556989

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_685035.4	Gene:	LOC556989 / 556989	-ID:	-	Length:	1124	Species:	Danio rerio

Alignment Length:	950	Identity:	312/950 - (32%)
Similarity:	469/950 - (49%)	Gaps:	163/950 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SQLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKK---------RFQEDLIYTYIGQVLISV 78
            |.||..:.....||.     ::.||...:.|.:..|.:         ||.::|||||||.:|:::
Zfish    20 SDLKFVSSRRSLDRE-----IMEENLPEDLANLSELDEKCLLEVLTGRFTQNLIYTYIGDILVAI 79

  Fly    79 NPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEE----NRGQCVLISGESGSGKTE 139
            ||:|.|.||..:..:.|:......:|||||||.|.|::|::..    .:.||::||||||:||||
Zfish    80 NPFKYLSIYEKEVSQRYKCHEKKSLPPHIFAVADRAYQSMLGRLAMGPKNQCIVISGESGAGKTE 144

  Fly   140 ASKKVLQFI-AACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQF---DFK 200
            ::|.:|:.| ..|..|..    ::.::|:.||:|||||||:|..||||||||||:.::|   ..|
Zfish   145 STKLLLRHIMELCKANSQ----LEQQILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRFQNSSVK 205

  Fly   201 GAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALD--TYSYLTDGLN 263
            ||.|.    .|||||||||.|..||:||||||.:|||..   |::..:...||  .|.|    ||
Zfish   206 GAKIN----EYLLEKSRVVHQDQGEQNFHIFYLMLAGIS---LEDKEIYGLLDPTLYRY----LN 259

  Fly   264 GTVTRINDAD-------SFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNA-KVN 320
            |   |....|       .:.:|..|:.::.|.::|:.::..|:|.||.|||:.|...:.:| ||:
Zfish   260 G---RFGQEDVVQTWRVKYAEVCNAMDMVGFEEQEKVDMMTILAGILSLGNITFETTDSDALKVS 321

  Fly   321 --SRDLVVTAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWL 383
              ||..:...|...||...:|..:||..|...||:.:....||:.|..|||::||..|.|:|.|:
Zfish   322 EASRGWLKATAGQFGVQEEDLLKSLTCTTSMTRGEAIQRLHNQQQAEDARDSIAKVAYGRVFGWI 386

  Fly   384 VQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEY 448
            |.::|..|..|.......|.:|||||:|||.|..|.|||.|||..||:||..|.......||.||
Zfish   387 VSKINEQLAPKVDFDVELNEIGILDIFGFENFAVNRFEQLCINLANEQLQYFFNHHIFLMEQKEY 451

  Fly   449 RREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHY-VC 512
            :.|||.|..:.|.|||.|.:|...|..||:|:|||:...| :.||:.|::||..|.....:: |.
Zfish   452 KEEGITWETITYKDNKPILDLFLMKPIGILSLLDEQSAFP-QATDRDFVDKLNSKFKSAPNFEVV 515

  Fly   513 HEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKE----------------TL 561
            ....|.          |.:|||||:|.|:.:|||:||.|.:...::|                |:
Zfish   516 RNHTPL----------FTVVHYAGKVQYNASGFLEKNRDTIPASIRELFINSVTPLLSVLFAATI 570

  Fly   562 SKAGNGIVRNCFPEKELRSLK-------RPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQ 619
            |:.|     ...|.|....:.       |.::...||:.||..||:.:....|.::||||||..:
Zfish   571 SRTG-----TLMPRKAKLQVSDDNFNSTRKQSVGAQFKHSLAVLMEKMFAASPHFVRCIKPNRSK 630

  Fly   620 TANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYK-SLSKSTWPNYKGPGGPKAGV 683
            ..:..:.:|||.|::|.||||.:|:||.||::|.|:..|.|||. .|.|...|.      .|:..
Zfish   631 QPDQLDSKLVLDQLRYNGLMETIRIRRDGFSWRPTFREFAERYNILLLKPDLPT------DKSSC 689

  Fly   684 QQLVKDL---GWDEEKYRVGETKLFIRWPRTLFDTEDA-YQEKKHEIAAIIQAHWKGLMQRRKYL 744
            ..::...   ||     :.|.::||.   :.....|.| ..::....|.:||.:::....|||||
Zfish   690 MSILNSTELSGW-----KCGSSRLFF---KLCHQVELANLLDRLGRAALVIQKNFRARTCRRKYL 746

  Fly   745 KLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLLRL 809
            .|.|::       ||:  :||.::|.|..::.|       .|.:......::..|..||.  |.:
Zfish   747 CLLAEL-------RRQ--RQAQREREEREEEER-------RRQEEEKRRQQQQEAERKRR--LEV 793

  Fly   810 AKE----------LPTKVLDKSWPHAPGHCEEASGILHRLHR-LHLARIYRLKLTPQQKRQFELK 863
            .:|          ||.|...:..|.:         :|..:.: ..:|.:.|    |:.      |
Zfish   794 EQENLRPASPPVPLPRKKKPEPRPRS---------VLSSISKTASVAPVPR----PRS------K 839

  Fly   864 VLAEKVFKGKKN-NYASSVSTWFQ---EDRIPKEHIQRVN 899
            :|....|....| |:....|...|   |:||.::|:::.|
Zfish   840 LLEATPFDNDLNENFHLDASLMLQPIDEERIKEKHLKKSN 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	266/745 (36%)
		MYSc_Myo1	52..707	CDD:276829	260/711 (37%)
		Myosin_TH1	863..1035	CDD:283635	11/40 (28%)
LOC556989	XP_685035.4	MYSc	34..711	CDD:214580	262/729 (36%)
		MYSc_Myo28	53..711	CDD:276854	258/705 (37%)
		SH2	895..992	CDD:301589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910