DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and myo1ha

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_009299653.1	Gene:	myo1ha / 556606	ZFINID:	ZDB-GENE-060531-78	Length:	1059	Species:	Danio rerio

Alignment Length:	1035	Identity:	502/1035 - (48%)
Similarity:	705/1035 - (68%)	Gaps:	24/1035 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYT 88
            ||.:|..|..|||.|:||||||:.:.||.||:.||||||.|||||||||.:||||||||:|.|||
Zfish    33 QLDLEGALIARDRVGIQDFVLLDAHNSETAFLDNLKKRFTEDLIYTYIGTLLISVNPYKELDIYT 97

  Fly    89 DDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG 153
            ...:..|...:|:|:||||:|:.|||:.:::.|.....:|||||||:||||||||:||:.|....
Zfish    98 KKQMDLYMGVNFFELPPHIYALADNAYHTMLSEANNHFILISGESGAGKTEASKKILQYYAVSCP 162

  Fly   154 NQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRV 218
            :.|.::.|:|::|.|||||||||||||.:||||||||||||||||.:|..:||:||:||||||||
Zfish   163 SSTLLDTVRDRMLMSNPVLEAFGNAKTMKNDNSSRFGKYMDIQFDIQGDAVGGHILSYLLEKSRV 227

  Fly   219 VAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALT 283
            |.|..|||||||||||:.|.:|.||::|.|||....|.||..|....|:.|||.:.:|.|:.||:
Zfish   228 VHQNHGERNFHIFYQLVEGGEEDLLRQLGLERDTKRYCYLVQGECSNVSSINDKNDWKTVKNALS 292

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGF-TEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRT 347
            ||||...:...:|||::|:||||||.| .:.:|.|.:||...:...::||||:...|..|||.|.
Zfish   293 VIDFDASDTEHLFGIISSVLHLGNVHFDRDTKGYAILNSNAALRWVSKLLGVHVQVLHGALTFRK 357

  Fly   348 IDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGF 412
            |:|:.:.|.||...:.|||||||||||:|||.|:|||.|:|.||:.|:  :.|..|:|:||||||
Zfish   358 IEAKSEEVLSPYTVDHAIYARDALAKAIYDRAFTWLVNRINESLENKD--SERKTVIGLLDIYGF 420

  Fly   413 EIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGI 477
            |:|..|||||||||:||||||||||:||||:||:||..|||.|.||::|:||:||:|:||||:||
Zfish   421 EVFTANSFEQFCINYCNEKLQQLFIQLTLKAEQEEYEAEGIGWEPVQFFNNKIICDLVEEKHRGI 485

  Fly   478 ISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSV 542
            ||:|||||:|||:.||.||||||.:|:..|.|:|.|:.|....:|.:.|.:|||:||||||||.|
Zfish   486 ISVLDEECVRPGDATDLTFLEKLEEKMGNHPHFVTHKLADKKTRKSLERGDFRLLHYAGEVTYCV 550

  Fly   543 NGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAITQFRASLNNLMDILMCKEP 607
            .||:|||||||::::|:.:..:.|.|::.|||..:..|.:||||..|||:.||..|.:||..||.
Zfish   551 VGFIDKNNDLLYKNIKDMMRLSKNPIIQQCFPATKAESRRRPETVATQFKNSLLRLTEILTAKEA 615

  Fly   608 SYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPN 672
            .|:||:|.||.:....|::.||.||||||||||:||||||||||||.||:||:|||.|..:|||:
Zfish   616 WYVRCLKSNDNKQQGKFDEVLVRHQVKYLGLMEHLRVRRAGFAYRRKYEVFLKRYKPLCPATWPH 680

  Fly   673 YKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGL 737
            ::|.  |..||::||:.||:..::|::|.||:|||:.||||.||||::..|||:|..:||.:||.
Zfish   681 WRGV--PSEGVEKLVQHLGYQPDEYKMGRTKIFIRYARTLFATEDAFEICKHELATKLQAKYKGY 743

  Fly   738 MQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAK 802
            ..:.::.|.:.....:::..|...|::...:|..|...|:.||||::||.:|....|.|::|..:
Zfish   744 KVKGEFRKQKEAATKIETCWRGVQARKERDRRAWAVKVIKKFIKGYLTRREAKTTDNSEYLAFVR 808

  Fly   803 RMWLLRLAKELPTKVLDK-SWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLA 866
            :.:|.||...||..|||| :|...|....|.|.||.:||...:.|.|...:|||:|.|.:.||:.
Zfish   809 QSYLNRLKANLPKTVLDKTTWLTPPPVMTETSEILRKLHTRMMVRKYVRGITPQKKAQMQQKVVT 873

  Fly   867 EKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRF 931
            ..:|||||::|.||::..|.:.||.:   |.:|..|..|...|::||.....|:||:|:|.|.|.
Zfish   874 SAIFKGKKDSYPSSIAVPFVDTRINE---QDINMRVLQTIRHERIKYSVPVVKYDRNGFKPRQRQ 935

  Fly   932 ILLSNKAIYVLDGKTYKQKHRLPLDKIDF------TLTNHNDDLMVIRIPLDLKKDKGDLILIIP 990
            ::|:..|.::::....||       ::|:      :::|..|.:|::.:..:..|.||||:|...
Zfish   936 LILTQAAAHLVEEAKIKQ-------RVDYVSLKGASVSNLGDSVMILHVAFNDPKQKGDLVLQCD 993

  Fly   991 RIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQTGAEPGVVR-DKGHLVII 1049
            .:.|..|.:.......:.:::| :.|::..:..||...:|..||.||.:.: ..|||:::
Zfish   994 HLFEALTKLAMIANKQNNITVV-QGSIKFEIQAGKQNAVDFSTGQEPMIYKGPNGHLMVV 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	395/688 (57%)
		MYSc_Myo1	52..707	CDD:276829	373/655 (57%)
		Myosin_TH1	863..1035	CDD:283635	49/177 (28%)
myo1ha	XP_009299653.1	MYSc	43..724	CDD:214580	393/684 (57%)
		MYSc_Myo1	62..713	CDD:276829	373/654 (57%)
		Myosin_TH1	870..1037	CDD:283635	49/177 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5516
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1057	1.000	Inparanoid score	I249
OMA	1	1.010	-	-		QHG52678
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		otm24419
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2957
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840