Protein Alignment Myo61F and myo1b

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_005168005.1
• Gene: myo1b / 541515
• ZFINID: ZDB-GENE-030131-695
• Length: 1167
• Species: Danio rerio
• Alignment Length: 1150
• Identity: 480/1150 - (41%)
• Similarity: 674/1150 - (58%)
• Gaps: 181/1150 - (15%)

  Fly    25 LKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTD 89
            ::::|.|.: :..||.|.||||.. |||:||.||||||..:.||||||.|:||:||||.|.||:.
Zfish     1 MEVKTSLLD-NMIGVGDMVLLEPL-SEESFIENLKKRFDHNEIYTYIGSVVISMNPYKSLSIYSA 63

  Fly    90 DHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGN 154
            :.|:.|||::|||:.|||:|:.|.|:|||..:::.||:||:||||:|||||||.|:.::||..|.
Zfish    64 EKVEEYRNRNFYELSPHIYALADEAYRSLRHQDKDQCILITGESGAGKTEASKFVMSYVAAVCGK 128

  Fly   155 QTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVV 219
            ...|..||::||:|||||||||||||.||||||||||||||:|||||.|:||.|.||||||||||
Zfish   129 GQEVNKVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVV 193

  Fly   220 AQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLT-DGLNGTVTRINDADSFKQVQQALT 283
            .|..||||||||||||:||.:.:|::|:|:|....|:||: |  :.||..::||.||:.|:.|:.
Zfish   194 KQPRGERNFHIFYQLLSGASDDMLKKLKLDRDFSKYNYLSLD--SATVNGLDDAASFRTVRNAMQ 256

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGF---TEVEG--NAKVNSRDLVVTAARLLGVNASELEAAL 343
            ::.|.::|.:.|..::|::|.|||:.|   :.|.|  .::|..::.:.....|||:..|.||.|.
Zfish   257 IVGFMEDEVQSILELIAAVLKLGNIEFKPESRVNGFDESRVKDKNDLKEMCELLGIEQSVLERAF 321

  Fly   344 THRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILD 408
            :.||::|:.:.|::.||...|.||||||||.:|.|||:|||.|:|.|::| :|: :|..|||:||
Zfish   322 SFRTVEAKMEKVSTTLNVAQAYYARDALAKNLYSRLFTWLVNRINESIKA-QTK-TRKKVMGVLD 384

  Fly   409 IYGFEIFQK--NSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIE 471
            |||||||:.  ||||||.||:|||||||:||||||:.||:||.||||||..:|||:|.:||:|||
Zfish   385 IYGFEIFENGDNSFEQFIINYCNEKLQQIFIELTLREEQEEYIREGIEWTNIEYFNNAIICDLIE 449

  Fly   472 EKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDE------FR 530
            ....||:::|||||||||..||:|||:||....|:|.|:   |...:...| .|.|.      ||
Zfish   450 NNKNGILAMLDEECLRPGTVTDETFLDKLNTVCAEHQHF---ESRLSKNSK-FLTDHSLPHNCFR 510

  Fly   531 LVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELR--SLKRPETAITQFRA 593
            :.||||:|.|.|.||:|||||||:|||.:.:.||.:.:::..|||....  :||||.||..||||
Zfish   511 IQHYAGKVLYRVEGFVDKNNDLLYRDLSQAMYKANHNLIKLLFPEGNPAKVNLKRPPTAGFQFRA 575

  Fly   594 SLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELF 658
            |:..||..|:.|.|:|||||||||.:.|::|.|.||.|||:|||||||:||||||:|:|:.||..
Zfish   576 SVGTLMKNLLTKNPNYIRCIKPNDKKAAHIFTDSLVCHQVRYLGLMENVRVRRAGYAFRQAYEPC 640

  Fly   659 LERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKK 723
            |||||.|.|.|||::|||.  :.||:.|:.||....|::..|.:|:|||.|||||..|:..::..
Zfish   641 LERYKMLCKQTWPHWKGPA--REGVEVLLSDLQVPAEEFAYGRSKIFIRNPRTLFFLEEKRRQCL 703

  Fly   724 HEIAAIIQAHWKG-----------------------LMQRRKYLKLRAQVIIMQSYCR----RKL 761
            .::||:||..::|                       ..|::||.|:|...:::||:.|    |||
Zfish   704 EDLAALIQKIYRGWKCRTHFLLLKKSQVVVAAWYRRFAQQKKYQKIRCSALVVQSFIRGWKARKL 768

  Fly   762 AQQAAKKRR--EAADKIRAFIKGFITR-------NDAPN-------------------------- 791
            .::...|:|  ||...|.|:..|...|       .:|.|
Zfish   769 LRELKHKKRCEEAVTTISAYWHGTQARWELRRLKKEAWNKHAVSVIWAAWLGTKARRELQKLKHE 833

  Fly   792 --------------------------------------------------GFNEEFIANAKR--- 803
                                                              .:.:.|.|||.:
Zfish   834 ACSKQAVSVIWACWQGTKARRELKRLKEEARRKHAIAVIWAYWLGLKVRREYRKFFRANAGKKIY 898

  Fly   804 ---------MWLLRLAKELPT-KVLDKSWPHAP-GHCEEASGILHRLHRLHLARIYRLKLTPQQK 857
                     .:.|.|.|.:|: ..:||||...| |..:.....|.|:..|...:.||.:.|.::|
Zfish   899 DFTIQRIIQKYYLGLKKTMPSMSPIDKSWSTCPYGFLDGTHQELRRIFHLWRCKKYRSQFTEEKK 963

  Fly   858 RQFELKVLAEKVFKGKKNNYASSVSTWFQEDRI-----PKEHIQRVNDFVASTFGSEQLKYQSFC 917
            ..:|.|:.|.::||.||..|.||||..|:.|.:     ||  .|::|..|     .:::......
Zfish   964 ATYEEKLAASELFKDKKALYPSSVSQPFKGDYVEITKNPK--YQKLNSLV-----EDKVLLADVV 1021

  Fly   918 TKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPL-DKIDFTLTNHNDDLMVIRIPLDLKKD 981
            :|.:|...|...|..||:.|.:.:.|.||.:.|..:|| |.....::..||....::    |::.
Zfish  1022 SKINRANGKGTPRIFLLTKKCLVLADQKTGQVKASVPLPDLSSVFVSTQNDGFFALK----LREG 1082

  Fly   982 -----KGDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNV 1021
                 |||.:|...|:||..|.:..| |.||    .:||.::.::
Zfish  1083 ATSAAKGDYLLSSDRLIEIITKLYCT-GAAS----AERNQIKIDI 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	381/703 (54%)
		MYSc_Myo1	52..707	CDD:276829	364/670 (54%)
		Myosin_TH1	863..1035	CDD:283635	49/169 (29%)
myo1b	XP_005168005.1	MYSc	13..700	CDD:214580	381/697 (55%)
		MYSc_Myo1	26..687	CDD:276829	364/670 (54%)
		Myosin_TH1	969..1142	CDD:283635	49/169 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720