Protein Alignment Myo61F and MYO3A

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_059129.3
• Gene: MYO3A / 53904
• HGNCID: 7601
• Length: 1616
• Species: Homo sapiens
• Alignment Length: 955
• Identity: 293/955 - (30%)
• Similarity: 470/955 - (49%)
• Gaps: 162/955 - (16%)

  Fly    43 VLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHI 107
            :|.||..||:     |:|.:..|.||.|:|.:||::||::.|.:|:..|.|.|........||||
Human   348 ILDENTVSEQ-----LEKCYSRDQIYVYVGDILIALNPFQSLGLYSTKHSKLYIGSKRTASPPHI 407

  Fly   108 FAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG------VKDKLL 166
            ||:.|..::|:|..|..||::||||||:||||.:..::|        |.||.|      :::|:|
Human   408 FAMADLGYQSMITYNSDQCIVISGESGAGKTENAHLLVQ--------QLTVLGKANNRTLQEKIL 464

  Fly   167 KSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIF 231
            :.|.::||||||.|..||||||||||::::|...||.:|..|..||||||||:.|..||:|||||
Human   465 QVNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNFHIF 529

  Fly   232 YQLLAG-ADEALLQELRLERALDTYSYLTDGLNGTVTRINDA---DSFKQVQQALTVIDFTKEEQ 292
            |.:.|| |::..|...:|...........|.|......:|::   ..::.::|...||.||.|:.
Human   530 YYIYAGLAEKKKLAHYKLPENKPPRYLQNDHLRTVQDIMNNSFYKSQYELIEQCFKVIGFTMEQL 594

  Fly   293 REIFGIVASILHLGNVGFTEVE-----GNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARG 352
            ..|:.|:|:||::||:.|:.|.     ..:.:::...:...|.||.:.|.||:.|||...:..||
Human   595 GSIYSILAAILNVGNIEFSSVATEHQIDKSHISNHTALENCASLLCIRADELQEALTSHCVVTRG 659

  Fly   353 DVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNN---VMGILDIYGFEI 414
            :.:..|...|.|...|||:||.:|.|||||:|..:| ||...::..|.|.   .:|||||:|||.
Human   660 ETIIRPNTVEKATDVRDAMAKTLYGRLFSWIVNCIN-SLLKHDSSPSGNGDELSIGILDIFGFEN 723

  Fly   415 FQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIIS 479
            |:||||||.|||..||::|..:.:.....||:||..|.::...:||.||..:.::..:|..|::|
Human   724 FKKNSFEQLCINIANEQIQYYYNQHVFAWEQNEYLNEDVDARVIEYEDNWPLLDMFLQKPMGLLS 788

  Fly   480 ILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNG 544
            :||||...| :.||:|.:||....|...:.:        ..|::.|  .|.:.||||:|.|:.:|
Human   789 LLDEESRFP-KATDQTLVEKFEGNLKSQYFW--------RPKRMEL--SFGIHHYAGKVLYNASG 842

  Fly   545 FLDKNNDLLFRDLKETLSKAGNGIVRNC----------FPEKELRSL------------------ 581
            ||.||.|.|..|:...|..:.|.::|..          .|..:.:::
Human   843 FLAKNRDTLPTDIVLLLRSSDNSVIRQLVNHPLTKTGNLPHSKTKNVINYQMRTSEKLINLAKGD 907

  Fly   582 -------------KRPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQV 633
                         .:.:|..:.||.||.:|:..::..:|.::||||||..:.|..::.|.||.|:
Human   908 TGEATRHARETTNMKTQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNSERQARKYDKEKVLLQL 972

  Fly   634 KYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAG---VQQLVKDLGWDEE 695
            :|.|::|..|:||.||::|..:..|::||..|.      ||....|:..   ...:::..|.|
Human   973 RYTGILETARIRRLGFSHRILFANFIKRYYLLC------YKSSEEPRMSPDTCATILEKAGLD-- 1029

  Fly   696 KYRVGETKLFIRWPRTLFDTEDAYQEKKHEI--AAIIQAHWKGLMQRRKYLKL----RAQVIIMQ 754
            .:.:|:||:|:::    :..|.....:|..|  ..:|||..:..:..|:|.|:    :...||:|
Human  1030 NWALGKTKVFLKY----YHVEQLNLMRKEAIDKLILIQACVRAFLCSRRYQKIQEKRKESAIIIQ 1090

  Fly   755 SYCRRKLAQQAAKKRREAADKIRAFI-------------KGF------ITRNDAPNGF--NEEFI 798
            |..|..|.:   |:|:|..|.....:             |.|      ..:..|.|..  ||.||
Human  1091 SAARGHLVR---KQRKEIVDMKNTAVTTIQTSDQEFDYKKNFENTRESFVKKQAENAISANERFI 1152

  Fly   799 ANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLH-----LARIYR--------- 849
            :.......:.:.|....|      |.     ||.:..:...:|::     :..:|.
Human  1153 SAPNNKGSVSVVKTSTFK------PE-----EETTNAVESNNRVYQTPKKMNNVYEEEVKQEFYL 1206

  Fly   850 --LKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQ---EDR 889
              .:::|:||   .:|.|.|.....|.....:.:.:::|   |:|
Human  1207 VGPEVSPKQK---SVKDLEENSNLRKVEKEEAMIQSYYQRYTEER 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	244/716 (34%)
		Myosin_TH1	863..1049	CDD:461801	7/30 (23%)
MYO3A	NP_059129.3	STKc_myosinIIIA_N	2..287	CDD:132969
		MYSc_Myo3	352..1041	CDD:276830	247/721 (34%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	934..956		8/21 (38%)
		Interaction with MORN4. /evidence=ECO:0000269|PubMed:25822849	1401..1479
		MBD_Myo3a	1409..1456	CDD:439318
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1545..1567
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1581..1616