Protein Alignment Myo61F and MYO15A

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_016880204.1
• Gene: MYO15A / 51168
• HGNCID: 7594
• Length: 3531
• Species: Homo sapiens
• Alignment Length: 912
• Identity: 326/912 - (35%)
• Similarity: 505/912 - (55%)
• Gaps: 97/912 - (10%)

  Fly    32 HERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYR 96
            |..|  ||:|...||:.| |...:.|||.||:.:|||||||.:|:|||||:...||..:.|:.|.
Human  1219 HGED--GVEDMTQLEDLQ-ETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFGIYGPEQVQQYN 1280

  Fly    97 NKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGV 161
            .:...|.|||:|||.:.||..:::..:.||::||||||||||||:|.:|:::||.:..:..::.|
Human  1281 GRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQKREVMQQV 1345

  Fly   162 KDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILN-YLLEKSRVVAQMGGE 225
             .::|::.|:||:||||||.||||||||||:::|..:  |..|.|.|.: |||||||:|.|...|
Human  1346 -IQILEATPLLESFGNAKTVRNDNSSRFGKFVEIFLE--GGVISGAITSQYLLEKSRIVFQAKNE 1407

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            ||:||||:||||....|.|...|:.| :||.||..|.|..:...:|||.|:::..|:.|:.|:.|
Human  1408 RNYHIFYELLAGLPAQLRQAFSLQEA-ETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFSSE 1471

  Fly   291 EQREIFGIVASILHLGNVGFTEVEGNAK-----VNSRDLVVTAARLLGVNASELEAALTHRTIDA 350
            :|..||.|:|||||||||.|.:.|.:|:     |::|: :...|.||.::...|:.|:|.:..:.
Human  1472 DQDSIFRILASILHLGNVYFEKYETDAQEVASVVSARE-IQAVAELLQISPEGLQKAITFKVTET 1535

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIF 415
            ..:.:.:||..|.|:.||||:||.:|..|||||:.|:|..:..::...|    :.||||||||..
Human  1536 MREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVNALVSPRQDTLS----IAILDIYGFEDL 1596

  Fly   416 QKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISI 480
            ..|||||.|||:.||.||.||.::..:.||:||.||.|:|..:.:.||:...|||..|..||:.|
Human  1597 SFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQPCINLISLKPYGILRI 1661

  Fly   481 LDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGF 545
            ||::|..| :.||.|||:|.      |:|   |...|.:.|..|...||.:.||||:|||.|:.|
Human  1662 LDDQCCFP-QATDHTFLQKC------HYH---HGANPLYSKPKMPLPEFTIKHYAGKVTYQVHKF 1716

  Fly   546 LDKNNDLLFRDLKETLSKAGNGIVRNCF--------PEK-----ELRSLKRPETAITQFRASLNN 597
            ||||:|.:.:|:.:...::...:|.:.|        |::     .:..|.:..|...:|:.||.:
Human  1717 LDKNHDQVRQDVLDLFVRSRTRVVAHLFSSHAPQAAPQRLGKSSSVTRLYKAHTVAAKFQQSLLD 1781

  Fly   598 LMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERY 662
            |::.:....|.::||:|||..:...:|..::|:.|::|.|::|.:|:|:.||..|..::.|::||
Human  1782 LVEKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRY 1846

  Fly   663 KSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIA 727
            ..|...   .:..|......|..|.:........||||.:|||::  ..|:...::.:|....:|
Human  1847 CCLVAL---KHDLPANGDMCVSVLSRLCKVMPNMYRVGVSKLFLK--EHLYQLLESMREHVLNLA 1906

  Fly   728 AI-IQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPN 791
            |: :|...:|...:|::..||.::|::||..|..||:|..::.|.:..|.|:.:..:::|..
Human  1907 ALTLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSLVKFRSLVHAYVSRRR--- 1968

  Fly   792 GFNEEFIANAKRMWLLRLAKELPTKV----------LDKSWPHAPGHCE---EASGILHRLHRLH 843
                          .|:|..|...:|          |.|....|.||.|   |.:|:|..:..|.
Human  1969 --------------YLKLRAEWRCQVEGALLWEQEELSKREVVAVGHLEVPAELAGLLQAVAGLG 2019

  Fly   844 LARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNY--ASSVSTWFQE--------------DRIPK 892
            ||::.::......:.|.|.:|......    |||  |..|...|:|              .::|.
Human  2020 LAQVPQVAPVRTPRLQAEPRVTLPLDI----NNYPMAKFVQCHFKEPAFGMLTVPLRTPLTQLPA 2080

  Fly   893 EH 894
            ||
Human  2081 EH 2082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	268/673 (40%)
		Myosin_TH1	863..1049	CDD:461801	11/48 (23%)
MYO15A	XP_016880204.1	SGP	<320..364	CDD:435798
		PHA03247	<723..1144	CDD:223021
		MYSc_Myo15	1236..1888	CDD:276838	268/673 (40%)
		IQ	1926..1947	CDD:197470	9/20 (45%)
		MyTH4	2066..2218	CDD:214535	3/17 (18%)
		PHA03247	<2433..2673	CDD:223021
		SH3_MYO15A	2872..2951	CDD:213000
		MyTH4	3051..3205	CDD:214535
		FERM_M	3300..3420	CDD:459788
		FERM_C_MyoXV	3416..3517	CDD:270022