Protein Alignment Myo61F and Myo15a

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001414755.1
• Gene: Myo15a / 501699
• RGDID: 1561873
• Length: 3512
• Species: Rattus norvegicus
• Alignment Length: 891
• Identity: 319/891 - (35%)
• Similarity: 496/891 - (55%)
• Gaps: 84/891 - (9%)

  Fly    32 HERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYR 96
            |..|  ||:|...||:.| |...:.|||.||:.:|||||||.:|:|||||:...||..:.|:.|.
  Rat  1208 HRED--GVEDMTQLEDLQ-ETTVLTNLKTRFERNLIYTYIGSILVSVNPYRMFAIYGPEQVQQYS 1269

  Fly    97 NKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGV 161
            .:...|.|||:||:.:.||..:::..:.|||:||||||||||||:|.:|:.:||.:..:..::.:
  Rat  1270 GRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLLLRCLAAMNQRRDVMQQI 1334

  Fly   162 KDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILN-YLLEKSRVVAQMGGE 225
              |:|::.|:|||||||||.||||||||||:::|..:  |..|.|.|.: |||||||:|.|...|
  Rat  1335 --KILEATPLLEAFGNAKTVRNDNSSRFGKFVEIFLE--GGVICGAITSQYLLEKSRIVFQAKNE 1395

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            ||:||||:||||....|.|...|:.| :||.||..|.|..:...:|||.|:::..|:.|:.||.|
  Rat  1396 RNYHIFYELLAGLPAQLRQAFSLQEA-ETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFTSE 1459

  Fly   291 EQREIFGIVASILHLGNVGFTEVEGNAK-----VNSRDLVVTAARLLGVNASELEAALTHRTIDA 350
            :|..||.|:|||||||||.|.:.|.:|:     |::|: :...|.||.|:...|:.|:|.:..:.
  Rat  1460 DQDSIFRILASILHLGNVYFEKHETDAQEVASVVSARE-IQAVAELLQVSPEGLQKAITFKVTET 1523

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIF 415
            ..:.:.:||..|.|:.||||:||.:|..||.||:.|:|..:..|:...|    :.||||||||..
  Rat  1524 IREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPKQDTLS----IAILDIYGFEDL 1584

  Fly   416 QKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISI 480
            ..|||||.|||:.||.||.||.::..:.||:||.||.::|..:.:.||:...|||..|..||:.|
  Rat  1585 SFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQPCINLISLKPYGILRI 1649

  Fly   481 LDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGF 545
            ||::|..| :.||.|||:|.      |:|   |...|.:.|..|...||.:.||||:|||.|:.|
  Rat  1650 LDDQCCFP-QATDHTFLQKC------HYH---HGANPLYCKPKMPLPEFTIKHYAGKVTYQVHKF 1704

  Fly   546 LDKNNDLLFRDLKETLSKAGNGIVRNCF-------------PEKELRSLKRPETAITQFRASLNN 597
            ||||:|.:.:|:.:....:...:|.:.|             ....:..|.:..|...:|:.||.:
  Rat  1705 LDKNHDQVRQDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYKAHTVAAKFQQSLLD 1769

  Fly   598 LMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERY 662
            |::.:....|.::||:|||..:...:|..::::.|::|.|::|.:|:|:.||..|..:::|::||
  Rat  1770 LVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRY 1834

  Fly   663 KSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIA 727
            :.|...   ....|......|..|.:......:.||||.:|||::  ..|....::.:|:....|
  Rat  1835 RCLVAL---KLNVPADGDMCVSLLSRLCTVTPDMYRVGVSKLFLK--EHLHQLLESMRERVLNRA 1894

  Fly   728 AI-IQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPN 791
            |: :|.:.:|...:|::..||.::|::||..|..||:|..::.|::..|.|:.:..::.|.....
  Rat  1895 ALTLQRYLRGFFTQRRFRSLRQKIILLQSRARGFLARQRYQQMRQSLLKFRSLVHTYVNRRRYLK 1959

  Fly   792 GFNEEFIANAKRMWLL---RLAK---------ELPTKVLDKSWPHAPGHCEEASGIL-HRLHRLH 843
             ...|....|:..||.   .|:|         |:|.:|        .|..:.|:|:. ..:.::.
  Rat  1960 -LRAERRRRAQEAWLREQEELSKREVVPVRHLEVPAEV--------AGLLQAAAGLKPSSVPQVA 2015

  Fly   844 LARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNY--ASSVSTWFQE 887
            :.|..||:..|......::            |||  |..:...|:|
  Rat  2016 IVRAPRLQAEPCVTLPLDI------------NNYPMAKFIRCHFKE 2049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	268/673 (40%)
		Myosin_TH1	863..1049	CDD:461801	6/27 (22%)
Myo15a	NP_001414755.1	None