DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo7b

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001178870.1	Gene:	Myo7b / 498834	RGDID:	1561153	Length:	2152	Species:	Rattus norvegicus

Alignment Length:	992	Identity:	317/992 - (31%)
Similarity:	493/992 - (49%)	Gaps:	181/992 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAY 95
            :|.....||.|.:.|.:. :|...:.||..|:|:..||||.|.:|::|||::.||:||.:.|:.|
  Rat    59 MHPNSAQGVDDMIRLGDL-NEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIY 122

  Fly    96 RNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG 160
            .::|..|:|||:||:.::.:.::.:..|.||.:||||||:||||.:|.:|||:|..||..:.:|
  Rat   123 YSRHMGELPPHVFAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATVSGQHSWIE- 186

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
              .::|::||:|||||||||.|||||||||||:||.|:..|...|.:|.::|||||||..|...|
  Rat   187 --QQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAAEE 249

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDT-YSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTK 289
            ||:||||.:|.|.  :|.::..|...:.: |.|||.|...:...::||..:..|:.|:.::.|:.
  Rat   250 RNYHIFYCMLMGM--SLEEKNMLGLGMPSEYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILQFSD 312

  Fly   290 EEQREIFGIVASILHLGNVGF-TEVEGNAKVNSRDLVVT-----AARLLGVNASELEAALTHRTI 348
            .|..:|..::|:||||||||| ..|..|  ::|.|::.|     |.:||.|....|...|...||
  Rat   313 SENWDISKLLAAILHLGNVGFMAAVFEN--LDSSDVMETPAFPFAMKLLEVQHQALRDCLIKHTI 375

  Fly   349 DARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRN--NVMGILDIYG 411
            ...|:.|:.|||...|...|||..|.:|..||.|:|:::|.::...:.:..:|  ..:|:|||:|
  Rat   376 PILGEFVSRPLNIAQAADRRDAFVKGIYGHLFLWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFG 440

  Fly   412 FEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKG 476
            ||.||.|||||.||||.||.|||.|::.....||:||..|.|.|..:.|.||:.|.:::..|...
  Rat   441 FENFQNNSFEQLCINFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMS 505

  Fly   477 IISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRD-EFRLVHYAGEVTY 540
            |||:||||...| :.||.|.|:||..         .|....:.::...:.| .|.:.|:||:|.|
  Rat   506 IISLLDEESRFP-QGTDVTMLQKLNS---------IHANNKSFLRPKSIHDTRFGIAHFAGDVYY 560

  Fly   541 SVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCF----PEKEL--------------------RSL 581
            ...|||:||.|:|..|:...:..:.|..::..|    |:.:|                    .|.
  Rat   561 QAEGFLEKNRDVLSTDILILIHSSKNKFLKEIFNLDLPQTKLGHGTICQVKTKTGGQIFKPSDST 625

  Fly   582 KRPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRR 646
            ||..|..:||:.||..||.||...:|.::||||||:.:...:|:.||.:.|::|.|:||.:.:|:
  Rat   626 KRSVTLSSQFKQSLEQLMKILTNCQPYFVRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRK 690

  Fly   647 AGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKD--LGWDEEKYRVGETKLFIRWP 709
            :||..|.|::.|.:|::.|..|  |...........:...:.|  ||.|:| :::|:||:|::
  Rat   691 SGFPIRYTFDEFSQRFRVLLPS--PERVQFQNKHRQMTSRIADLCLGTDKE-WKMGKTKIFLK-- 750

  Fly   710 RTLFDTEDAYQE----------------------------KKHEIAAIIQAHWKGLMQR------ 740
                |.:|...|                            ::...|..:||.|:|..||
  Rat   751 ----DHQDTMLEIQRSQALDGAAIRIQRVLRGHKYRKEFLRQKRAAVTLQAVWRGHNQRKNFKLI 811

  Fly   741 -----------------RKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRND 788
                             |::..:|.:::.:|:.||..|.:|..:.:|.|...|:|..:|.:.|
  Rat   812 LMGFERLQAIARSHLLMRQFQTMRQKIVQLQARCRGYLVRQQVQAKRRAVVIIQAHARGMVAR-- 874

  Fly   789 APNGFNEEFIANAKRMWLLR-------LAKE-------------------------------LPT 815
                         |..|..:       ||||                               ||.
  Rat   875 -------------KSYWQQKSSGPPVILAKEPKGQGVALDRKRKSIYDTVTDTAMVEKVFGFLPA 926

  Fly   816 KVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASS 880
            .:..:..| ||...|:......:||.:.|..:...::..:     ::..|||..|       ...
  Rat   927 MIGGQEGP-APTRFEDLEVKTQKLHEVDLDTVPMTEMPGE-----DVDGLAEYTF-------PKF 978

  Fly   881 VSTWFQEDRIPKEHIQR 897
            ..|:||:. ....|||:
  Rat   979 AVTYFQKS-ASHTHIQK 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	271/723 (37%)
		MYSc_Myo1	52..707	CDD:276829	263/690 (38%)
		Myosin_TH1	863..1035	CDD:283635	10/35 (29%)
Myo7b	NP_001178870.1	MYSc	60..761	CDD:214580	272/727 (37%)
		MYSc_Myo7	79..750	CDD:276832	263/690 (38%)
		IQ	787..809	CDD:197470	7/21 (33%)
		MyTH4	991..1194	CDD:214535	3/4 (75%)
		B41	1201..1414	CDD:214604
		FERM_B-lobe	1304..1405	CDD:271216
		FERM_C1_MyoVII	1408..1504	CDD:270019
		SH3	1505..1565	CDD:302595
		MyTH4	1646..1793	CDD:214535
		B41	1802..2014	CDD:214604
		FERM_M	1912..2014	CDD:278785
		FERM_C2_MyoVII	2010..2105	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910