Protein Alignment Myo61F and Myo3a

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001406660.1
• Gene: Myo3a / 498806
• RGDID: 1560083
• Length: 1614
• Species: Rattus norvegicus
• Alignment Length: 1006
• Identity: 305/1006 - (30%)
• Similarity: 494/1006 - (49%)
• Gaps: 196/1006 - (19%)

  Fly    17 DYIDFNSQL-KMETGLHER--------DRA------GVQDF----VLLENYQSEEAFIGNLKKRF 62
            ::||.:..| ..|...|||        :|:      .|.|.    ||.||..||     :|:|.:
  Rat   303 EFIDIHQCLGSTEKARHERIHTKKGNLNRSLISSLKDVDDLATLDVLDENTVSE-----HLEKCY 362

  Fly    63 QEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCV 127
            ..|.||.|:|.:||::||::.|.:|:....|.|........|||||||.|..::|::..|..||:
  Rat   363 SRDQIYIYVGDILIALNPFQSLGLYSTKLSKLYIGAKRTANPPHIFAVADLGYQSMVTYNADQCI 427

  Fly   128 LISGESGSGKTEASKKVLQFIAAC--SGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFG 190
            :||||||:||||::..::|.:...  :.|:|    :::|:|:.|.::||||||.|..||||||||
  Rat   428 VISGESGAGKTESAHLLVQHLTVLGKANNRT----LQEKILQMNNLVEAFGNACTIINDNSSRFG 488

  Fly   191 KYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADE----AL--LQELRLE 249
            ||::::|...||.:|..|..||||||||:.|..||:||||||.:.||..|    ||  |.|.:..
  Rat   489 KYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNFHIFYYIYAGLAEKKKLALYKLPENKPP 553

  Fly   250 RAL--DTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTE 312
            |.|  |....:.|.:|.:..:    ..::.::|...||.||.|:...::.::|:||::||:.|:.
  Rat   554 RYLQNDNLRTVQDMMNNSFYK----SQYELIEQCFKVIGFTMEQLGSVYSVLAAILNVGNIEFSS 614

  Fly   313 VEGNAKVN-----SRDLVVTAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALA 372
            |....:::     :...:..:|.||.:.|.||:.|||...:..||:.:..|...|.|...|||.|
  Rat   615 VATEYQMDKSYICNHTALENSASLLCIQADELQEALTSHCVVTRGETIIRPNTVEKATDVRDATA 679

  Fly   373 KAVYDRLFSWLVQRLNISLQAKETRASRNNVM--GILDIYGFEIFQKNSFEQFCINFCNEKLQQL 435
            |.:|.|||||:|..:| ||...:|..|.|..:  |||||:|||.|:||||||.|||..||::|..
  Rat   680 KTLYGRLFSWIVNCIN-SLLKHDTSPSGNEELNIGILDIFGFENFKKNSFEQLCINIANEQIQYY 743

  Fly   436 FIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKL 500
            |.:.....||:||..|.::...:||.||:.:.::..:|..|::.:||||...| :.||:|.:||.
  Rat   744 FNQHVFAWEQNEYLNEDVDARVIEYEDNRPLLDMFLQKPMGLLFLLDEESRFP-KATDQTLVEKF 807

  Fly   501 TQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAG 565
            ...|...:.:        ..|::.|  .|.:.||||:|.||.:|||.||.|.|..|:...|..:.
  Rat   808 EDNLKSQYFW--------RPKRMEL--SFGIHHYAGKVLYSASGFLAKNRDTLPTDIVLLLRSSE 862

  Fly   566 NGIVRNC--------------------------------FPEKELRSLKR---------PETAIT 589
            |.::|..                                ..:.|.|.:.|         .:|..:
  Rat   863 NSVIRQLVNHPLTKTGNLPLSKTKNIVNYQMQNSEKSTNLNKSETRDVTRHAYETTNVKTQTVSS 927

  Fly   590 QFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRT 654
            .||.||.:|:..::..:|.::||||||:.:.|..::.|.||.|::..|::|..|:||.|:::|..
  Rat   928 YFRYSLMDLLSKMVVGQPHFVRCIKPNNDRQARKYDKEKVLIQLRCTGILETARIRRLGYSHRIL 992

  Fly   655 YELFLERYKSLSKSTWPNYKGPGGP------------KAGVQQLVKDLGWDEEKYRVGETKLFIR 707
            :..|::||..|.      ||....|            |||:           :.:.:|:||:|::
  Rat   993 FANFIKRYYVLC------YKSSEEPPVSPDTCATILEKAGL-----------DNWALGKTKVFLK 1040

  Fly   708 WPRTLFDTEDAYQEKKHEI--AAIIQAHWKGLMQRRKYLKL----RAQVIIMQSYCRRKLAQQAA 766
            :    :..|.....:|..|  ..:|||..:..:..::|.:|    :...:|:||..||.|.::..
  Rat  1041 Y----YHVEQLNLMRKEAIDKLVLIQASVRAFLGAKRYQELQQKRKTSAVIIQSAARRHLLRKQG 1101

  Fly   767 KK----RREAADKIRA------FIKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKS 821
            ||    :..|...:||      :.|.|.|:.::   |.::...||           :||...:..
  Rat  1102 KKTSNVQSTAGMSVRAKDQEFDYKKNFETKRES---FVKKHTENA-----------VPTNESNIP 1152

  Fly   822 WPH----------APGHCEEASGILHRLHRLH-----LARIYR--------------LKLTPQQK 857
            .|:          ||...|..:..:...:|.:     ::.:|.              ::::|:||
  Rat  1153 TPNNKESPSAGKTAPFRAEAKATNVESNNRKYQTQKKMSNVYAEGQNQELYIVGDSWVEVSPRQK 1217

  Fly   858 RQFELKVLAEKVFKGKKNN-YASSVSTWFQE 887
            ...:|:. :.|:.|.:|.: ...|...|:.|
  Rat  1218 YVQDLEE-SRKLRKEEKGDAVIQSYCQWYTE 1247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	246/724 (34%)
		Myosin_TH1	863..1049	CDD:461801	6/26 (23%)
Myo3a	NP_001406660.1	Protein Kinases, catalytic domain	2..287	CDD:473864
		MYSc_Myo3	352..1040	CDD:276830	249/729 (34%)
		MBD_Myo3a	1408..1455	CDD:439318