Protein Alignment Myo61F and Myo19

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001157208.1
• Gene: Myo19 / 497974
• RGDID: 1559961
• Length: 964
• Species: Rattus norvegicus
• Alignment Length: 981
• Identity: 302/981 - (30%)
• Similarity: 468/981 - (47%)
• Gaps: 147/981 - (14%)

  Fly    20 DFNSQLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQL 84
            |....|..|..||:.|.....:.|.|      |..:..|:.|:.||:.||..|..|:::||:|.:
  Rat    23 DLREFLGGEVPLHQLDDLTKVNPVTL------ETVLRCLQARYTEDIFYTNAGCTLVALNPFKHI 81

  Fly    85 P-IYTDDHVKAYRNKHFYEMP----PHIFAVTDNAFR---SLIEENRGQCVLISGESGSGKTEAS 141
            | :|..:.::.|   |....|    ||||.|.:..:|   ||||. ..|.:::|||||:|||..|
  Rat    82 PQLYAPELMQEY---HAAPQPQKLKPHIFTVGEQTYRNVKSLIEP-INQSIVVSGESGAGKTWTS 142

  Fly   142 KKVLQFIAACSGNQTTVEG------VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFK 200
            :.:::|.|..:.:.|:.|.      :::::|.||||:||||||.|.||:|||||||::.:|.:..
  Rat   143 RCLMKFYAVVAASPTSCENHKMAERIEERILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRA 207

  Fly   201 GAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERAL---DTYSYLTDGL 262
            ....|..:..|||||:||..|...|||||||||:..||    .:|.||:..|   ..:|:|.:..
  Rat   208 QQMTGAAVQTYLLEKTRVACQAASERNFHIFYQICKGA----TKEERLQWCLPEGTAFSWLPNPE 268

  Fly   263 NGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAKV-----NSR 322
            :..     :.|.|:..::|:..:......|..||.::|.:||||||.|.:.|..|:.     .::
  Rat   269 SSL-----EEDCFEVTREAMLHLGIDTPTQNNIFKVLAGLLHLGNVHFVDSEDEAQPCQLMDGTK 328

  Fly   323 DLVVTAARLLGVNASELEAALTHRTIDA--RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQ 385
            ..|.|:|.||.:..:.|..::..|||.|  :..|...|.::......||.|||.:|.|||.|||.
  Rat   329 GSVRTSALLLQLPDNMLLESMQIRTIKAGKQQQVFQKPCSRAECDTRRDCLAKLIYARLFDWLVS 393

  Fly   386 RLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRR 450
            .:|.|:.|  ..:|....:|:||:||||.|..||.||.|||:.||||||.|:...|:::|:||..
  Rat   394 VINSSICA--DFSSWTAFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYEV 456

  Fly   451 EGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEK 515
            ||:||..|.|.||:...:|:|.....|.|:::||| |...|:....|:...:........:.|
  Rat   457 EGLEWSFVNYQDNQTCLDLLEGSPISICSLINEEC-RLNRPSSAAQLQTRIESTLAGRPCLGH-- 518

  Fly   516 APAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFP------ 574
                 .|:.....|.::|:||.|.|...|.::||.|.:..:|...|.::.:.::...||
  Rat   519 -----NKLSREPSFVVMHFAGPVRYCTAGLVEKNKDPVPPELTGLLQQSQDPLLMMLFPANPEEK 578

  Fly   575 -EKELRSLKRPE--TAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYL 636
             ::||....|..  |.:::|:|||..|:.:|....|.||||||||.......|..|.||:|::..
  Rat   579 TQEELSGQSRAPALTVVSKFKASLEQLLQVLHKTTPHYIRCIKPNSQSQPQTFLQEEVLNQLEAC 643

  Fly   637 GLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPK--AGVQQLVKDLGWDEEKYRV 699
            ||:|.:.:..|||..|.:::.|:||||.|::..         |:  :|::.|....|..|:....
  Rat   644 GLVETIHISAAGFPIRVSHQNFMERYKLLTRLR---------PRTSSGLRSLCPAKGSSEQPLCA 699

  Fly   700 GETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAH--------------WKG---LMQRRKYLKL- 746
            .|..|           :...|:..|.:.|:||..              :.|   :......|:|
  Rat   700 KEATL-----------QPLLQDILHALPALIQTATTPSDPAKTAQIPLYCGRTKIFMTDSMLELL 753

  Fly   747 ---RAQVIIMQSYC------RRKLAQQAAKKRREAADKIRAFIKGFITRNDAPN-GFNEEFIANA 801
               |||::...:.|      |.:|.:|  :|:|.||..|:|..:.::||..... ......|.:|
  Rat   754 ECGRAQMLEQCARCIQCGWRRHRLQKQ--EKQRRAAVIIQAAFRSWLTRKHIRRLHIAATVIKHA 816

  Fly   802 KRMWLLRLAKELPTKVLD----KSWPHAPG---------HCEEASGILHRLHRLHLARIYRLKLT 853
            ...|.:|:|. |.:|.||    |..|.|||         |......|:| |..|.|.    |..:
  Rat   817 WHKWRIRMAC-LASKELDGMEEKLMPQAPGTLRSSLSPAHTRFLGAIIH-LWPLGLV----LANS 875

  Fly   854 PQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGS-------EQL 911
            ....|.|:.|::|....:...:..::.|.|       |::....:....|...||       ..|
  Rat   876 ADGMRGFQRKLVAHACLRLPASGPSNKVQT-------PQQDQAGITSIRALPQGSIKFHCRKSPL 933

  Fly   912 KYQSFC 917
            :|...|
  Rat   934 QYADIC 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	237/689 (34%)
		Myosin_TH1	863..1049	CDD:461801	11/62 (18%)
Myo19	NP_001157208.1	MYSc_Myo19	49..746	CDD:276846	243/739 (33%)
		IQCD	776..>801	CDD:467745	9/26 (35%)