Protein Alignment Myo61F and myo1a

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001008063.1
• Gene: myo1a / 493425
• XenbaseID: XB-GENE-979281
• Length: 1073
• Species: Xenopus tropicalis
• Alignment Length: 1090
• Identity: 462/1090 - (42%)
• Similarity: 653/1090 - (59%)
• Gaps: 110/1090 - (10%)

  Fly    19 IDFNSQLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQ 83
            :||.|...  .|:     .||.|.:|||:. |||:.:.|||:||:.|.||||||.|:|||||||.
 Frog     1 MDFKSSFM--DGM-----VGVGDMILLESL-SEESLLVNLKERFKSDEIYTYIGNVVISVNPYKS 57

  Fly    84 LPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFI 148
            ||||:.:.|:.|||.:.|::.|||:||.|:|::||.:.:|.||:||:||||:|||||||.|:.::
 Frog    58 LPIYSPEKVEEYRNCNLYQLKPHIYAVADDAYQSLRDRDRDQCILITGESGAGKTEASKLVMSYV 122

  Fly   149 AACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLL 213
            ||..|..|.|..||::||:|||||||||||||.||||||||||||||:|||||.|:||.|.||||
 Frog   123 AAVCGKGTEVNQVKEQLLQSNPVLEAFGNAKTIRNDNSSRFGKYMDIEFDFKGDPMGGVISNYLL 187

  Fly   214 EKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTD---GLNGTVTRINDADSF 275
            ||||||..:.||||||||||||||....||.:|:|......|:||.:   .|||    :.|.::|
 Frog   188 EKSRVVKNVKGERNFHIFYQLLAGGGTELLGKLKLVPDCSKYNYLNNDPSSLNG----MGDNENF 248

  Fly   276 KQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAKVNSRDL--------VVTAARLL 332
            :.|:.|:.:|..:..|...|..|||.||.||||   |::|..:.|....        :.....|:
 Frog   249 QIVKNAMEIIGLSDAEVTSILEIVAVILKLGNV---EIKGQFQANGMAACYITDTKGIKEIGALI 310

  Fly   333 GVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETR 397
            |:::|.||.|.:.||::|:.:.|.:.|||...|||||||||.:|||||||||||:|.|::..|.:
 Frog   311 GLDSSMLENAFSVRTVEAKQEKVVTTLNQSQGIYARDALAKNLYDRLFSWLVQRINESIKVSEFQ 375

  Fly   398 ASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFD 462
            ..:  |||:||||||||.:.||||||.||:|||||||:||::|||.||:||.||||:|..:.|.|
 Frog   376 GRK--VMGVLDIYGFEILEVNSFEQFIINYCNEKLQQIFIQMTLKEEQEEYTREGIKWTRIVYTD 438

  Fly   463 NKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKI---M 524
            |:|||.|||:...||:::|||||||||:.:|.|||.||..|...|.|:  ..|...:.|:|   .
 Frog   439 NEVICTLIEDNTNGILAVLDEECLRPGKVSDATFLAKLGTKFKNHKHF--QSKVTQNDKRIADLT 501

  Fly   525 LRDE-FRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELR--SLKRPET 586
            |.|. ||:.||||:|||:.:||||||||||||||.:.:..|.:.:::..|||.:.:  |||||.|
 Frog   502 LPDNCFRIEHYAGQVTYNTDGFLDKNNDLLFRDLSQAMWNAKHQLLKTLFPEGDPKNSSLKRPPT 566

  Fly   587 AITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAY 651
            ...|||.|::.||..|..|.|:||||:|||..:..::|:|.||..|:.||||:||::||||||||
 Frog   567 VGFQFRNSVSTLMKNLYAKNPNYIRCLKPNSSKKPSLFDDVLVKTQILYLGLLENVKVRRAGFAY 631

  Fly   652 RRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTE 716
            |:.|:.||||||.:||.|||.:.|..  :.||..::.:||..:|:..:|.||:|||.|.||||.|
 Frog   632 RQLYKPFLERYKMISKKTWPQWAGEA--RDGVAAMMAELGIPDEEAALGHTKIFIRTPSTLFDLE 694

  Fly   717 DAYQEKKHEIAAIIQ-----------------------AHWKGLMQRRKYLKLRAQVIIMQSYCR 758
            |..:.:..|:|.:||                       |.::|..|:::|.|::...:::|:|.|
 Frog   695 DRRRRRLDELATLIQTLFRGWRCRTHFLLMRKSQIVISAFYRGHAQKKEYQKIKFSALLLQAYVR 759

  Fly   759 --------RKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKR------------ 803
                    ||.  :..|::..|:..|.|:.:|:..|.:    |.:.|.:.|.:
 Frog   760 GWKARVLLRKF--KLDKRKESASSTICAYWRGYKVRKE----FRKRFKSTASKKLANFIYLRILQ 818

  Fly   804 MWLLRLAKELPT-KVLDKSW-PHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLA 866
            |:.|.|.|.:|: ...:|:| |........||..:.|:......:.:|..||||:|...:.|:.|
 Frog   819 MYFLGLKKNVPSMSPTNKTWAPPKYKFLAPASQEIMRIFHHWKCKKFRENLTPQKKAILQDKLCA 883

  Fly   867 EKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRF 931
            .::|.|||..|.:||:..||.|.:..:...::....:...|  :|...:...:..:...|.....
 Frog   884 SELFNGKKKCYPASVAKPFQGDYVGIQKNPKLQKGASGVSG--KLLVAANVERITKTNGKGSPML 946

  Fly   932 ILLSNKAIYVLDGKTYKQKHRLPLDKI-DFTLTNHNDDLMVIRI-PLDLKKDKGDLILIIPRIIE 994
            :||:|..:.::..|. :.|....||:| ..:::..||.:.||:: |......|||.:|.....||
 Frog   947 LLLTNTHLGLMTTKG-QVKSLAKLDEIASVSVSKFNDGIFVIQLTPTATAGLKGDFLLSSLNTIE 1010

  Fly   995 FSTYIIDTVGTAS----IVSIVDRNS------------LEHNVVKGKGGV 1028
            ..:.:..:|..|:    .|.|.|..|            :|.:|..|||.|
 Frog  1011 ILSKLYQSVLEATKNKLNVKISDEFSVKFKKDPIALKFIEASVQNGKGPV 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	355/671 (53%)
		Myosin_TH1	863..1049	CDD:461801	46/184 (25%)
myo1a	NP_001008063.1	MYSc_Myo1	31..685	CDD:276829	354/666 (53%)
		IQCD	774..802	CDD:467745	8/31 (26%)
		Myosin_TH1	880..1064	CDD:461801	46/184 (25%)