DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo61F and MYO7B

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_016859658.1	Gene:	MYO7B / 4648	HGNCID:	7607	Length:	2164	Species:	Homo sapiens

Alignment Length:	991	Identity:	330/991 - (33%)
Similarity:	493/991 - (49%)	Gaps:	178/991 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAY 95
            :|.....||.|.:.|.:. :|...:.||..|:|:..||||.|.:|::|||::.||:||.:.|:.|
Human    59 MHPNSVQGVDDMIRLGDL-NEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTLEQVQLY 122

  Fly    96 RNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG 160
            .::|..|:|||:||:.:|.:.|:....|.||.:||||||:||||.:|.:|||:|..||..:.:|
Human   123 YSRHMGELPPHVFAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATISGQHSWIE- 186

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
              .::|::||:|||||||||.|||||||||||:||.|:..|...|..|..:|||||||..|...|
Human   187 --QQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEE 249

  Fly   226 RNFHIFYQLLAGA---DEALLQELRLERALDT---YSYLTDGLNGTVTRINDADSFKQVQQALTV 284
            ||:||||.:|.|.   |:.||       :|.|   |.|||.|...:...:|||..:..::.|:.:
Human   250 RNYHIFYCMLMGVSAEDKQLL-------SLGTPSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKI 307

  Fly   285 IDFTKEEQREIFGIVASILHLGNVGF-TEVEGNAKVNSRDLVVTAA-----RLLGVNASELEAAL 343
            :.|:..|..::..::|:||||||||| ..|..|  :::.|::.|.|     :||.|...||...|
Human   308 LQFSDSESWDVIKLLAAILHLGNVGFMASVFEN--LDASDVMETPAFPTVMKLLEVQHQELRDCL 370

  Fly   344 THRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRN--NVMGI 406
            ...||..||:.||..||...|...|||..|.:|..||.|:|:::|.::.....:..:|  ..:|:
Human   371 IKHTILIRGEFVTRSLNIAQAADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGL 435

  Fly   407 LDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIE 471
            |||:|||.|:.|||||.||||.||.|||.|::.....||:|||.|.|.|..:.|.||:...:|:.
Human   436 LDIFGFENFENNSFEQLCINFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLA 500

  Fly   472 EKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRD-EFRLVHYA 535
            .|...|||:||||...| :.||.|.|:||..         .|....|.::...:.| .|.:.|:|
Human   501 LKPMSIISLLDEESRFP-QGTDLTMLQKLNS---------VHANNKAFLQPKNIHDARFGIAHFA 555

  Fly   536 GEVTYSVNGFLDKNNDLLFRD------------LKETL------SKAGNGIVR------NCFPEK 576
            |||.|...|||:||.|:|..|            |:|..      :|.|:|.:|      :.|  |
Human   556 GEVYYQAEGFLEKNRDVLSTDILTLVYSSKNKFLREIFNLELAETKLGHGTIRQAKAGNHLF--K 618

  Fly   577 ELRSLKRPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMEN 641
            ...|.|||.|..:||:.||:.||.||...:|.:|||||||:.:...:|:.||.|.|::|.|:||.
Human   619 SADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELCLRQLRYSGMMET 683

  Fly   642 LRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKD--LG----W--DEEKYR 698
            :.:|::||..|.|:|.|.:|:..|.         |...:..:|..::.  ||    |  .::.::
Human   684 VHIRKSGFPIRYTFEEFSQRFGVLL---------PNAMRMQLQGKLRQMTLGITDVWLRTDKDWK 739

  Fly   699 VGETKLFIRWPRTLFDTEDAYQE----------------------------KKHEIAAIIQAHWK 735
            .|:||:|:|      |.:|...|                            ::...|..:||.|:
Human   740 AGKTKIFLR------DHQDTLLEVQRSQVLDRAALSIQKVLRGYRYRKEFLRQRRAAVTLQAWWR 798

  Fly   736 GLMQR-----------------------RKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIR 777
            |...|                       |:|..:|.:.:.:|:.||..|.:|..:.:|.|...|:
Human   799 GYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRGYLVRQQVQAKRRAVVVIQ 863

  Fly   778 AFIKGFITRND----APNGFNEEFIANA---KRMWLLRLAKE-------LPTKVLDKSWPHAPG- 827
            |..:|...|.:    ..||.....:..|   |....|...|.       ..|::::|.:...|.
Human   864 AHARGMAARRNFQQRKANGMQAPLVIPAEGQKSQGALPAKKRRSIYDTVTDTEMVEKVFGFLPAM 928

  Fly   828 ----------HCEEASGILHRLHRLHLARIYRLKLTPQ-QKRQFELKVLAEKVFKGKKNNYASSV 881
                      |.|:......:|..:.|..:      |. ::.:.::..|||..|       ....
Human   929 IGGQEGQASPHFEDLESKTQKLLEVDLDTV------PMAEEPEEDVDGLAEYTF-------PKFA 980

  Fly   882 STWFQEDRIPKEHIQR 897
            .|:||:. ....||:|
Human   981 VTYFQKS-ASHTHIRR 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	285/734 (39%)
		MYSc_Myo1	52..707	CDD:276829	276/701 (39%)
		Myosin_TH1	863..1035	CDD:283635	10/35 (29%)
MYO7B	XP_016859658.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910