Protein Alignment Myo61F and MYO7A

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_011543348.2
• Gene: MYO7A / 4647
• HGNCID: 7606
• Length: 2258
• Species: Homo sapiens
• Alignment Length: 1118
• Identity: 361/1118 - (32%)
• Similarity: 560/1118 - (50%)
• Gaps: 190/1118 - (16%)

  Fly    31 LHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAY 95
            :|.....||:|.:.|.:. :|...:.||..|:::.|||||.|.:|::||||:.|.||:.:|::.|
Human    89 MHPTSVHGVEDMIRLGDL-NEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHIRQY 152

  Fly    96 RNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG 160
            .||...||||||||:.||.:.::...:|.||.:||||||:||||::|.:|||:||.||..:.:|
Human   153 TNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIE- 216

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
              .::|::.|:|||||||||.|||||||||||:||.|:.:||..|..|..||||||||..|...|
Human   217 --QQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDE 279

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            ||:|:||.:|.|..|...::|.|.:|.| |:||..|...|.....|:..:..::.|:.|:.||..
Human   280 RNYHVFYCMLEGMSEDQKKKLGLGQASD-YNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDT 343

  Fly   291 EQREIFGIVASILHLGNVGFTEVEGNAKVNSRDL-----VVTAARLLGVNASELEAALTHRTIDA 350
            |..||..::|:||||||:.: |......:::.::     :.|||.||.||..:|.:.||.||:..
Human   344 ENWEISKLLAAILHLGNLQY-EARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLIT 407

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISL---QAKETRASRNNVMGILDIYGF 412
            ||:.|::||::|.|:..|||..|.:|.|||.|:|.::|.::   .:::.:.||.:: |:|||:||
Human   408 RGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSI-GLLDIFGF 471

  Fly   413 EIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGI 477
            |.|..|||||.||||.||.|||.|:....|.||:||..|.|:|:.:|:.||:...::|..|...|
Human   472 ENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNI 536

  Fly   478 ISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYV----CHEKAPAHIKKIMLRDEFRLVHYAGEV 538
            ||::|||...| :.||.|.|.||..:...:.:|:    .||            .:|.:.|:||.|
Human   537 ISLIDEESKFP-KGTDTTMLHKLNSQHKLNANYIPPKNNHE------------TQFGINHFAGIV 588

  Fly   539 TYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPE-----KELRSLKRPETAITQFRASLNNL 598
            .|...|||:||.|.|..|:.:.:..:.|..::..|..     .|.|  ||..|..:||:.||..|
Human   589 YYETQGFLEKNRDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETR--KRSPTLSSQFKRSLELL 651

  Fly   599 MDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYK 663
            |..|...:|.::||||||:.:...:|:..|.:.|::|.|:||.:|:||||:..|.::..|:|||:
Human   652 MRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYR 716

  Fly   664 SLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQE------- 721
            .|.....|.|| .|..:...|::.:.:....:.:::|:||:|::      |..|...|
Human   717 VLLPGVKPAYK-QGDLRGTCQRMAEAVLGTHDDWQIGKTKIFLK------DHHDMLLEVERDKAI 774

  Fly   722 ---------------------KKHEIAAIIQAHWKGLMQRRKY-------LKLRA---------- 748
                                 |....|.:||.||:|...|:.|       |:|:|
Human   775 TDRVILLQKVIRGFKDRSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQ 839

  Fly   749 ------QVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFI--ANAKRMW 805
                  ::|..|:.||..|.::|.:.|..|...::|:.:|.|.|. .......|::  ..|::|.
Human   840 YRLARQRIIQFQARCRAYLVRKAFRHRLWAVLTVQAYARGMIARR-LHQRLRAEYLWRLEAEKMR 903

  Fly   806 LL---RLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYR------LKLTPQQKRQFE 861
            |.   :|.||:..|...          |||    .|.|:..||::.|      ||.....:|:.|
Human   904 LAEEEKLRKEMSAKKAK----------EEA----ERKHQERLAQLAREDAERELKEKEAARRKKE 954

  Fly   862 LKVLAEKVFKGKKNNYASSVSTWF-----------QEDRIPK--EHIQRVNDFVASTFGSEQLKY 913
            |....|:. :.:..|::..|...|           ||.:.|.  |.::|         |..::..
Human   955 LLEQMERA-RHEPVNHSDMVDKMFGFLGTSGGLPGQEGQAPSGFEDLER---------GRREMVE 1009

  Fly   914 QSFCTKF--------DRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHNDD-- 968
            :......        |...||       .:..|.....|.|.....|.||.:   .|..|:|:
Human  1010 EDLDAALPLPDEDEEDLSEYK-------FAKFAATYFQGTTTHSYTRRPLKQ---PLLYHDDEGD 1064

  Fly   969 --------LMVIRIPLDLKK--------DKGDLILIIPRIIEF---STY-----IIDTVGTASIV 1009
                    :.::|...||.:        |..:.|.::.:|.|.   .||     .:...|.|.:.
Human  1065 QLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKRELQALQGEGEAQLP 1129

  Fly  1010 SIVDRNSLEHNVV 1022
            ....::|:.|.:|
Human  1130 EGQKKSSVRHKLV 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	271/671 (40%)
		Myosin_TH1	863..1049	CDD:461801	36/207 (17%)
MYO7A	XP_011543348.2	MYSc_Myo7	109..759	CDD:276832	271/671 (40%)
		CBD_MYO6-like	<796..>839	CDD:409646	12/42 (29%)
		tolA	<826..>996	CDD:236545	42/185 (23%)
		MAP7	<887..963	CDD:461709	22/90 (24%)
		MyTH4	1047..1283	CDD:214535	20/99 (20%)
		FERM1_F1_Myosin-VII	1287..1385	CDD:340612
		B41	1289..1504	CDD:214604
		FERM_C1_MyoVII	1498..1634	CDD:270019
		SH3	1635..1699	CDD:473055
		MyTH4	1793..1926	CDD:214535
		FERM2_F1_Myosin-VII	1931..2028	CDD:340613
		B41	1933..2145	CDD:214604