Protein Alignment Myo61F and MYO6

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001355794.1
• Gene: MYO6 / 4646
• HGNCID: 7605
• Length: 1294
• Species: Homo sapiens
• Alignment Length: 829
• Identity: 284/829 - (34%)
• Similarity: 433/829 - (52%)
• Gaps: 92/829 - (11%)

  Fly    33 ERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLP-IYTDDHVKAYR 96
            |..:..|:|...| .|.:|...:.|:|.|:.:|.||||:..:||:||||..:| ||:.:.:|:|:
Human    53 EDSKKDVEDNCSL-MYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQ 116

  Fly    97 NKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGV 161
            .|.....|||:||:.|.|||.:......|.:::|||||:||||.:|.||:::....|   |.:.:
Human   117 GKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYG---TGQDI 178

  Fly   162 KDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGER 226
            .|:::::||:|||||||||.||:|||||||:::|.|:.|.:.:||.:.:|||||||:..|...||
Human   179 DDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEER 243

  Fly   227 NFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTR----------------------- 268
            |:||||:|.|||.|.:.::|.|. :.|.:.||..|    .||
Human   244 NYHIFYRLCAGASEDIREKLHLS-SPDNFRYLNRG----CTRYFANKETDKQILQNRKSPEYLKA 303

  Fly   269 -------INDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEG-----NAKVNS 321
                   ::|...|.::..|:..|....||:.::|.:||.:|||||:.|.|...     |.|..|
Human   304 GSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKS 368

  Fly   322 RDLVVTAARLLGVNASELEAALTHRTI-----DARGDVVTSPLNQELAIYARDALAKAVYDRLFS 381
            ...:...|.|||::..:|..:||.|.:     ..:|.|:..||..|.|..|||||||.||..||.
Human   369 AQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFD 433

  Fly   382 WLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQD 446
            .:|.|:|.....:    :.:..:|:|||.|||.|:.|||||||||:|||||||.|.|..||.||:
Human   434 HVVNRVNQCFPFE----TSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQE 494

  Fly   447 EYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYV 511
            .|::||:....|.|.||:...:|||.|..||:.|||||...| :|:|:.|...:.||...|....
Human   495 LYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLP-QPSDQHFTSAVHQKHKDHFRLT 558

  Fly   512 CHEKAPAHIKKIMLRDE-FRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFP- 574
            ...|:...:.:.:..|| |.:.|:||.|.|....|::||||.|...|:..:.::.:..:|..|.
Human   559 IPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFES 623

  Fly   575 ----EKELRSLKRPETAIT---QFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQ 632
                .|:.:......:.|:   :|:..||.|:|.|.....|:|||||||...|::.|....:|.|
Human   624 STNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQ 688

  Fly   633 VKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKY 697
            ::..|::..|.:.:.|:..|.::......||..    .|:......|:...:.|.|.||.:|..|
Human   689 LQCSGMVSVLDLMQGGYPSRASFHELYNMYKKY----MPDKLARLDPRLFCKALFKALGLNENDY 749

  Fly   698 RVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQ--------AHWK-------GLMQRRKYLKLR 747
            :.|.||:|.| |....:.:...:.....:|.:::        :.||       .:::.:..:|.|
Human   750 KFGLTKVFFR-PGKFAEFDQIMKSDPDHLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYR 813

  Fly   748 AQVII-MQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNE 795
            |:..| ||...|..|.::..|.|.:...|:....|    |.|.   |||
Human   814 AEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKK----RLDK---FNE 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	256/704 (36%)
		Myosin_TH1	863..1049	CDD:461801
MYO6	NP_001355794.1	MYSc_Myo6	71..759	CDD:276833	256/704 (36%)
		Responsible for slow ATPase activity. /evidence=ECO:0000250|UniProtKB:Q29122	273..317		6/47 (13%)
		Actin-binding. /evidence=ECO:0000255	665..672		5/6 (83%)
		CBD_MYO6-like	770..917	CDD:409646	20/93 (22%)
		Required for binding calmodulin. /evidence=ECO:0000250|UniProtKB:Q29122	782..810		2/27 (7%)
		Three-helix bundle. /evidence=ECO:0000250|UniProtKB:Q29122	835..916		8/28 (29%)
		SAH. /evidence=ECO:0000269|PubMed:18511944	917..984
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	934..955
		MYO6_MIU_linker	999..1068	CDD:412090
		Interaction with TAX1BP1 and CALCOCO2/NDP52. /evidence=ECO:0000269|PubMed:31371777	1060..1285
		MyUb_Myo6	1082..1122	CDD:439319
		Interaction with OPTN. /evidence=ECO:0000250|UniProtKB:Q9I8D1	1116..1118
		Interaction with TOM1. /evidence=ECO:0000269|PubMed:31371777	1157..1285
		Myosin-VI_CBD	1177..1267	CDD:465157