Protein Alignment Myo61F and MYO5A

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001369277.1
• Gene: MYO5A / 4644
• HGNCID: 7602
• Length: 1904
• Species: Homo sapiens
• Alignment Length: 1187
• Identity: 367/1187 - (30%)
• Similarity: 559/1187 - (47%)
• Gaps: 250/1187 - (21%)

  Fly     6 KSLIFAIMDTKDYIDFNSQLKMETGLHERD---RAGVQDFVLLENYQSEEAFIGNLKKRF-QEDL 66
            |.|:..:.:.|| ::::...|.:...|.|:   ..|..|...| :|..|.|.:.||:.|| ...|
Human    60 KVLLLHLEEGKD-LEYHLDPKTKELPHLRNPDILVGENDLTAL-SYLHEPAVLHNLRVRFIDSKL 122

  Fly    67 IYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISG 131
            ||||.|.||:::|||:|||||.:|.:.||..::..:|.||||||.:.|::.:..:.|.|.:::||
Human   123 IYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSG 187

  Fly   132 ESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQ 196
            |||:|||.::|..:::.|..||:.:.. .|::|:|.|||::|:.|||||.|||||||||||::|.
Human   188 ESGAGKTVSAKYAMRYFATVSGSASEA-NVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIG 251

  Fly   197 FDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDG 261
            ||.:...||.|:..|||||||||.|...|||:||||||.|.|.....:.|||..| |.::|...|
Human   252 FDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNA-DNFNYTKQG 315

  Fly   262 LNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAKVNSRDL-- 324
            .:..:..::||......:||.|::..::..|..||.|:|.||||||||||         |||.
Human   316 GSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFT---------SRDADS 371

  Fly   325 ---------VVTAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLF 380
                     :.....|:||:..|:...|.||.:....:....|:::..|..|||||||.:|.:||
Human   372 CTIPPKHEPLCIFCELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLF 436

  Fly   381 SWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQ 445
            :|:|..:|   ||..:...:::.:|:|||||||.|:.|||||||||:.||||||.|.....|.||
Human   437 NWIVDNVN---QALHSAVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQ 498

  Fly   446 DEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHY 510
            :||.:|.|.|..::::||:...||||.| .||:.:|||||..| :.||.|:.:||         |
Human   499 EEYMKEQIPWTLIDFYDNQPCINLIESK-LGILDLLDEECKMP-KGTDDTWAQKL---------Y 552

  Fly   511 VCHEKAPAHIKKIMLRDE-FRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFP 574
            ..|....|..:|..|.:: |.:.|:|.:|.|...|||:||.|.:|.:..:.|..:...::...|.
Human   553 NTHLNKCALFEKPRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQ 617

  Fly   575 EKE----------------LRSLKRP-------------ETAITQFRASLNNLMDILMCKEPSYI 610
            :.|                .|:..:|             :|...|||.||:.||:.|....|.|:
Human   618 DDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKEHKKTVGHQFRNSLHLLMETLNATTPHYV 682

  Fly   611 RCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKG 675
            |||||||.:....|:::..:.|::..|::|.:|:..|||..|.||:.|..||:.|.|..    ..
Human   683 RCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQK----DV 743

  Fly   676 PGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEK----KHEIAAI-IQAHWK 735
            ....|...:.:::.|..|::||:.|:||:|.|..:.      ||.||    |...|.| ||...:
Human   744 LSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQV------AYLEKLRADKLRAACIRIQKTIR 802

  Fly   736 GLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAK--KRREAAD---------------KIR------ 777
            |.:.|:|||::|...|.||.|.|...|:..||  :|.:||.               |||
Human   803 GWLLRKKYLRMRKAAITMQRYVRGYQARCYAKFLRRTKAATIIQKYWRMYVVRRRYKIRRAATIV 867

  Fly   778 --AFIKGFITRNDAPNGFNEE---FIANAKRMWLLR--------------------LAK------ 811
              ::::||:.||.......|.   .|....|.||.|                    :||
Human   868 LQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMMAKRELKKL 932

  Fly   812 ----------------------ELPTKV---------LDKSWPHAPG-HCEEASGILHRLHRLHL 844
                                  :|..||         |.:...:..| :..|...:...|.||.|
Human   933 KIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQL 997

  Fly   845 A----------------RIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKE 893
            :                .|.:|:...:|.|. |.|.:.|...:.|:.. ...||...:|:.:.|:
Human   998 SEEEAKVATGRVLSLQEEIAKLRKDLEQTRS-EKKCIEEHADRYKQET-EQLVSNLKEENTLLKQ 1060

  Fly   894 HIQRVNDFVAS----------------------TFGSEQLKYQSFCTKFDR-------------- 922
            ..:.:|..:..                      ....|:|:||:...:|.|
Human  1061 EKEALNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTL 1125

  Fly   923 --H----GYKSRDRFILLSNKAIYVLDGKTYK-----------QKHRLPLD-----KIDFTLTNH 965
              |    |:|..|. ...||::.|:...:..:           .:.::|||     |:...:|..
Human  1126 MVHVPKPGHKRTDS-THSSNESEYIFSSEIAEMEDIPSRTEEPSEKKVPLDMSLFLKLQKRVTEL 1189

  Fly   966 NDDLMVIRIPLDLKKDK 982
            ..:..|::..||.|:::
Human  1190 EQEKQVMQDELDRKEEQ 1206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	268/696 (39%)
		Myosin_TH1	863..1049	CDD:461801	30/178 (17%)
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	367/1187 (31%)
		MYSc_Myo5	107..775	CDD:276831	268/696 (39%)
		Myo5a_CBD	1530..1904	CDD:271262