DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo61F and MYO1E

DIOPT Version :9

Sequence 1:NP_476934.2 Gene:Myo61F / 38153 FlyBaseID:FBgn0010246 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_004989.2 Gene:MYO1E / 4643 HGNCID:7599 Length:1108 Species:Homo sapiens


Alignment Length:966 Identity:382/966 - (39%)
Similarity:557/966 - (57%) Gaps:111/966 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 HERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYR 96
            |....:||.|.|||... :|.:.:.|||||:.:|.|:||||.|||||||:||:|.:.:..::.|:
Human    14 HNVKHSGVDDMVLLSKI-TENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQ 77

  Fly    97 NKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGV 161
            ....||.||||:|:.||.:|::|.:...|||:||||||:|||.|:|.::.:|:..||..|.|:.|
Human    78 GAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHV 142

  Fly   162 KDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGER 226
            ||.:|:|||:|||||||||.||:||||||||.:|||...|.|.||.|.|:||||||||.:..|||
Human   143 KDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGER 207

  Fly   227 NFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGT--VTRINDADSFKQVQQALTVIDFTK 289
            :|||||||:.||.......|.: .::|.|.||:  |:|:  |..|:|...|::...|:.||....
Human   208 SFHIFYQLIEGASAEQKHSLGI-TSMDYYYYLS--LSGSYKVDDIDDRREFQETLHAMNVIGIFA 269

  Fly   290 EEQREIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDA---- 350
            |||..:..|||.||||||:.|.||...|.|.|.:.:...|.|||:|...|:..||.|.:|:    
Human   270 EEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGG 334

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIF 415
            :.:.:...||.|.|.|.|||||||::.|:|.:||..:|   :|.|......|: |:|||||||||
Human   335 KSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSIN---KAMEKDHEEYNI-GVLDIYGFEIF 395

  Fly   416 QKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEK--HKGII 478
            |||.||||||||.||||||:|||||||:||:||.:|||.|.|:|||:||::|:|||.|  ..||:
Human   396 QKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIM 460

  Fly   479 SILDEECL---RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTY 540
            ||||:.|.   ..||..|:|.|:||..::..|.|:....:.            |.:.||||:|:|
Human   461 SILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQG------------FIIHHYAGKVSY 513

  Fly   541 SVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLK-RPETAITQFRASLNNLMDILMC 604
            .::||.::|.|:||.||.|.:..:....:::.|||......| ||.||.::.:...|:|:..||.
Human   514 DMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMK 578

  Fly   605 KEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKST 669
            ..|.||||||||:.:....:.:..|.|||:||||.||:||||||:||||.::.||:||..|:|:|
Human   579 CTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKAT 643

  Fly   670 WPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHW 734
            ||:::|.  .|.||..|::.:..|.:::::|.:|:||:.|.:||..|:..:.|....|.:||..|
Human   644 WPSWQGE--EKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSW 706

  Fly   735 KGLMQRRKYLKLR--AQVIIMQSYCRRK-------------------LAQQAAKKRR-EAADKIR 777
            :..:.|:||:::|  |..:::....||:                   |.|...|:.: :.||.:.
Human   707 RKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVT 771

  Fly   778 AFIKGFITRNDAPNGFNEEFIANAKRMWLL--RLAKELPTKVLDKSWPHAPGHCEEASGILHRLH 840
            .:.:.|       .|...:.:...|.::|:  ...|:.|.|.|.|.             :|.|  
Human   772 KYDRRF-------KGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKE-------------VLKR-- 814

  Fly   841 RLHLARIYRLKLTPQQKRQF-----ELKVLAEKVFKGKKNNYASSVSTWFQE---DRIPKE---- 893
            ::.:.||..:.|:..|...|     |...|.|.||   |..:.|.::..::|   .::|.:    
Human   815 KIEIERILSVSLSTMQDDIFILHEQEYDSLLESVF---KTEFLSLLAKRYEEKTQKQLPLKFSNT 876

  Fly   894 ---HIQRVNDFVASTFGSEQLKY-QSFCTKFDRHGYKSRDRFILL-SNKAIYVLDG 944
               .:::.|....|..||.|::: |.|           .|..:|. |||.:.|..|
Human   877 LELKLKKENWGPWSAGGSRQVQFHQGF-----------GDLAVLKPSNKVLQVSIG 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo61FNP_476934.2 MYSc 32..720 CDD:214580 326/699 (47%)
MYSc_Myo1 52..707 CDD:276829 313/666 (47%)
Myosin_TH1 863..1035 CDD:283635 22/94 (23%)
MYO1ENP_004989.2 MYSc 14..692 CDD:214580 326/699 (47%)
MYSc_Myo1 33..679 CDD:276829 313/666 (47%)
Actin-binding. /evidence=ECO:0000255 581..591 8/9 (89%)
Myosin_TH1 719..902 CDD:283635 39/207 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 919..966 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 993..1053
SH3_MyoIe_If_like 1056..1107 CDD:212761
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S951
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D122881at2759
OrthoFinder 1 1.000 - - FOG0000187
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100187
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.770

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