DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and MYO1D

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_056009.1	Gene:	MYO1D / 4642	HGNCID:	7598	Length:	1006	Species:	Homo sapiens

Alignment Length:	1060	Identity:	424/1060 - (40%)
Similarity:	614/1060 - (57%)	Gaps:	117/1060 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            |..||||::.....| |:.||:.||::..|||:||:|::||||||.|.||..|.::.|:.:..||
Human    10 GKADFVLMDTVSMPE-FMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYE 73

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACS--GNQTTVEGVKDKL 165
            .|||:||:.|.|::::...::..|::||||||:|||||||.::|:|||.:  ..:..||.||:.|
Human    74 RPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNML 138

  Fly   166 LKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHI 230
            ||||.|||||||||||||||||||||||||.|||||.||||:|.|||||||||:.|..|||:||.
Human   139 LKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHS 203

  Fly   231 FYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREI 295
            |||||.|..|.:|:.|.|:::|.:|:|:..|.. ..:.||||..|:.|..|:.||.|..||.:.:
Human   204 FYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQ-LKSSINDAAEFRVVADAMKVIGFKPEEIQTV 267

  Fly   296 FGIVASILHLGNVGFTEVEGNAKVNSRDLVVT-AARLLGVNASELEAALTHRTIDARGDVVTSPL 359
            :.|:|:||||||:.|. |:|:..:.....||: .|.||......:|.||.:||:....|::....
Human   268 YKILAAILHLGNLKFV-VDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRDIIDKQH 331

  Fly   360 NQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKE---TRASRNNVMGILDIYGFEIFQKNSFE 421
            .::.|.|.|||.|||:|:|||.|:|.|:|..::.|.   |...:|.|:|:|||||||||..||||
Human   332 TEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFE 396

  Fly   422 QFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECL 486
            |||||:||||||||||:|.||.||:||:||||.|..::||:|::|.:|:|::|||||:|||:.|:
Human   397 QFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACM 461

  Fly   487 RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNND 551
            ..|:.||:.|||.|..||.:|.|: ...|..|..|.:....:||:.||||:|.|||.||:|||.|
Human   462 NVGKVTDEMFLEALNSKLGKHAHF-SSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKD 525

  Fly   552 LLFRDLKETLSKAGNGIVRNCFPEKEL---RSLKRPETAITQFRASLNNLMDILMCKEPSYIRCI 613
            .||:|.|..:..:.|.:::|.:||.:|   ...|||.||.|.|:.|:..|:|.|..|||.|:|||
Human   526 TLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCI 590

  Fly   614 KPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGG 678
            ||||.::..:|:||...|||:||||:||:||||||||:|:|||.||.|||.:|:.||||:..| .
Human   591 KPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLP-S 654

  Fly   679 PKAGVQQLVKDLGW-DEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRK 742
            .|..|::|::..|: |:..|  |:||:|||.|||||..|:...:....|...:|..|:|.:.|.:
Human   655 DKEAVKKLIERCGFQDDVAY--GKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTLARMR 717

  Fly   743 YLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLL 807
            |.:.:|.:.|::.|.|.|                   :|.:|..             .|:|...:
Human   718 YKRTKAALTIIRYYRRYK-------------------VKSYIHE-------------VARRFHGV 750

  Fly   808 RLAKELPTKVLDKSWPHAP---GHCEEA-SGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEK 868
            :..::....|   .||..|   ...||| ..|.:|.....|.:.......||.:    .||.|.:
Human   751 KTMRDYGKHV---KWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLPQVR----AKVAAVE 808

  Fly   869 VFKGKK----------NNYASS------VSTWFQEDRIP-KEHIQRVNDFVASTFGSEQLKYQSF 916
            :.||::          .||.:|      .|..|    :| ...::|.:.::...|.....|...|
Human   809 MLKGQRADLGLQRAWEGNYLASKPDTPQTSGTF----VPVANELKRKDKYMNVLFSCHVRKVNRF 869

  Fly   917 CTKFDRHGYKSRDRFILLSNKAIYVLD-GKTYKQKHRLPLDKI-DFTLTNHNDDLMVIRIPLDLK 979
            .        |..||.|.::::.:|.:| .|.||....:||..: ..:::|..|.|:|..     .
Human   870 S--------KVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSNGKDQLVVFH-----T 921

  Fly   980 KDKGDLILIIPRIIEFSTYIIDTVGTASIVSIV------DRNSLEHNV-------VKGKGGVIDI 1031
            ||..|||:.:     ||...........:|.::      ::..|:.||       :.||...:.:
Human   922 KDNKDLIVCL-----FSKQPTHESRIGELVGVLVNHFKSEKRHLQVNVTNPVQCSLHGKKCTVSV 981

  Fly  1032 QT---GAEPGVVRDKGHLVI 1048
            :|   ..:|...:::...::
Human   982 ETRLNQPQPDFTKNRSGFIL 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	352/691 (51%)
		MYSc_Myo1	52..707	CDD:276829	339/664 (51%)
		Myosin_TH1	863..1035	CDD:283635	44/206 (21%)
MYO1D	NP_056009.1	MYSc	4..694	CDD:214580	352/690 (51%)
		MYSc_Myo1	24..682	CDD:276829	339/664 (51%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	572..594		12/21 (57%)
		Myosin_TH1	803..997	CDD:283635	45/215 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720