DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and MYO1A

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001242970.1	Gene:	MYO1A / 4640	HGNCID:	7595	Length:	1043	Species:	Homo sapiens

Alignment Length:	1041	Identity:	452/1041 - (43%)
Similarity:	641/1041 - (61%)	Gaps:	78/1041 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            ||:|.||||.. .||:.:.||:.|::...||||||.|:||||||:|||||..:.:..|::..|||
Human     9 GVEDLVLLEPL-VEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDYTFYE 72

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLK 167
            :.|||:|:.:.|::||.:.:|.||:||:||||||||||||.|:.::||..|....|..||::||:
Human    73 LKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQ 137

  Fly   168 SNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFY 232
            |||||||||||||.||:|||||||||||:|||||:|:||.|.||||||||:|.|:.|||||||||
Human   138 SNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGERNFHIFY 202

  Fly   233 QLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRI---NDADSFKQVQQALTVIDFTKEEQRE 294
            ||||||||.||:.|:|||....|:|    ||..|:|:   :||.||:.||.|:.||.|::||.|:
Human   203 QLLAGADEQLLKALKLERDTTGYAY----LNHEVSRVDGMDDASSFRAVQSAMAVIGFSEEEIRQ 263

  Fly   295 IFGIVASILHLGNV--------------GFTEVEGNAKVNSRDLVVTAARLLGVNASELEAALTH 345
            :..:.:.:|.||||              |..:..|..::         ..::|:|:.|:|.||..
Human   264 VLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREI---------GEMVGLNSEEVERALCS 319

  Fly   346 RTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIY 410
            ||::...:.|.:.||...|.||||||||.:|.|||.|:|.|:|.|:  |.....:..|||:||||
Human   320 RTMETAKEKVVTALNVMQAQYARDALAKNIYSRLFDWIVNRINESI--KVGIGEKKKVMGVLDIY 382

  Fly   411 GFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHK 475
            ||||.:.||||||.||:|||||||:|||:|||.||:||:||||.|..|:||||.:||.|||...:
Human   383 GFEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEHNQR 447

  Fly   476 GIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCH--EKAPAHIKKIMLRDEFRLVHYAGEV 538
            ||:::|||||||||..:|.|||.||.|..::|.||...  :.|.......|....||:.||||:|
Human   448 GILAMLDEECLRPGVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYAGKV 512

  Fly   539 TYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPE--KELRSLKRPETAITQFRASLNNLMDI 601
            ||:|..|:|||||||||||.:.:.||.:.::|:.|||  .:..|||||.||..||::|:..||..
Human   513 TYNVTSFIDKNNDLLFRDLLQAMWKAQHPLLRSLFPEGNPKQASLKRPPTAGAQFKSSVAILMKN 577

  Fly   602 LMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLS 666
            |..|.|:||||||||:.|....|:.:||..|.:||||:||:||||||:|:|:.|..|||||:.||
Human   578 LYSKSPNYIRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLERYRLLS 642

  Fly   667 KSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQ 731
            :||||::.  ||.:.||::::.:|.....:...|:||:|||.|:|||..|:..:.:..::|.:||
Human   643 RSTWPHWN--GGDREGVEKVLGELSMSSGELAFGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQ 705

  Fly   732 AHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEE 796
            ..::|...|..|..:|...|::.|:.|..:.::...|.:.:...|:||::|:..|.:....|..|
Human   706 KIYRGWRCRTHYQLMRKSQILISSWFRGNMQKKCYGKIKASVLLIQAFVRGWKARKNYRKYFRSE 770

  Fly   797 -------FIANAK-RMWLLRLAKELP-TKVLDKSWPHAPGHC-EEASGILHRLHRLHLARIYRLK 851
                   ||..:. :.:||.|...|| |.||||:||.||..| ..|:..|.:|......:.:|.:
Human   771 AALTLADFIYKSMVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQELQQLFYQWKCKRFRDQ 835

  Fly   852 LTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRI-----PKEHIQRVNDFVASTFGSEQ- 910
            |:|:|......|:.|.::|||||.:|..||...|..|.|     ||  :|::.       |.|:
Human   836 LSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPK--LQKLK-------GGEEG 891

  Fly   911 -LKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKI-DFTLTNHNDDLMVIR 973
             :.......|.:|...|:..|.:||:...:.:.|.|..:.|..:.||.: ..::|:..|.|..:.
Human   892 PVLMAEAVKKVNRGNGKTSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLH 956

  Fly   974 I-PLDLKKDKGDLILIIPRIIEFST----YIIDTVGTASIVSIVDR-------NSLEHNVVKGKG 1026
            : .:.....|||.:|:...:||..|    .::|.......|::.::       ||:...||:|..
Human   957 LSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVTVTEKFSVRFKENSVAVKVVQGPA 1021

  Fly  1027 G 1027
            |
Human  1022 G 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	363/702 (52%)
		MYSc_Myo1	52..707	CDD:276829	348/675 (52%)
		Myosin_TH1	863..1035	CDD:283635	47/185 (25%)
MYO1A	NP_001242970.1	MYSc	8..694	CDD:214580	363/702 (52%)
		MYSc_Myo1	22..681	CDD:276829	348/675 (52%)
		Actin-binding. /evidence=ECO:0000255	571..593		12/21 (57%)
		IQ	742..764	CDD:197470	6/21 (29%)
		Myosin_TH1	847..1021	CDD:283635	46/182 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720