Protein Alignment Myo61F and MYH11

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Alignment Length: 1104
• Identity: 328/1104 - (29%)
• Similarity: 539/1104 - (48%)
• Gaps: 190/1104 - (17%)

  Fly    50 SEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNA 114
            :|.:.:.||::|:...|||||.|...:.|||||.||||::..|..|:.|..:||||||:|:.|.|
Human    97 NEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTA 161

  Fly   115 FRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKD---------------- 163
            :||::::...|.:|.:||||:||||.:|||:|::|..:.:.   :|.||
Human   162 YRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSH---KGKKDTSITQGPSFAYGELEK 223

  Fly   164 KLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNF 228
            :||::||:|||||||||.:|||||||||::.|.||..|..:|.||..|||||||.:.|...||.|
Human   224 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTF 288

  Fly   229 HIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQR 293
            ||||.::|||.|.:..:|.|| ..:.|::|::|. ..:....|.:.|::..:|:.::.|::|||.
Human   289 HIFYYMIAGAKEKMRSDLLLE-GFNNYTFLSNGF-VPIPAAQDDEMFQETVEAMAIMGFSEEEQL 351

  Fly   294 EIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAAR----LLGVNASELEAALTHRTIDARGDV 354
            .|..:|:|:|.|||:.|.:.....:.:..|  .|||:    |:|:|.::...::....|....||
Human   352 SILKVVSSVLQLGNIVFKKERNTDQASMPD--NTAAQKVCHLMGINVTDFTRSILTPRIKVGRDV 414

  Fly   355 VTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNS 419
            |.....:|.|.:|.:|||||.|:|||.|::.|:|.:|.  :|.....:.:|||||.|||||:.||
Human   415 VQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALD--KTHRQGASFLGILDIAGFEIFEVNS 477

  Fly   420 FEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVICNLIEEKHK--GIISIL 481
            |||.|||:.||||||||.......||:||:||||||..::: .|.:....|||..:.  |::::|
Human   478 FEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALL 542

  Fly   482 DEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFL 546
            ||||..| :.|||:|:|||..:...|..:    :.|..:|.   :.||.::||||:|.|:.:.:|
Human   543 DEECWFP-KATDKSFVEKLCTEQGSHPKF----QKPKQLKD---KTEFSIIHYAGKVDYNASAWL 599

  Fly   547 DKNNDLLFRDLKETLSKAGNGIVRNCF---------------PEKELRSLKRPETAITQ-----F 591
            .||.|.|..::...|:.:.:..|.:.:               .|..|.|..:.:..:.:     :
Human   600 TKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLY 664

  Fly   592 RASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYE 656
            :..|..||..|....|:::|||.||..:.:...:..|||.|::..|::|.:|:.|.||..|..::
Human   665 KEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQ 729

  Fly   657 LFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQE 721
            .|.:||:.|:.:..|  ||....|.....::|.|..|...||:|::|:|.| ...|...|:....
Human   730 EFRQRYEILAANAIP--KGFMDGKQACILMIKALELDPNLYRIGQSKIFFR-TGVLAHLEEERDL 791

  Fly   722 KKHEIAAIIQAHWKGLMQRRKYLKLRAQVI---IMQSYCRRKL---------------------- 761
            |..::....||..:|.:.|:.:.|.:.|:.   ::|..|...|
Human   792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR 856

  Fly   762 -----------AQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPT 815
                       .|:..:::::|.::::...:......:..|...|:..|..:   |...|:|:..
Human   857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---LYAEAEEMRV 918

  Fly   816 KVLDKSWPHAPGHCEEASGILHRLH--------RLHLARIYRLKLTPQ---------------QK 857
            ::..|.        :|...|||.:.        |....:..|.|:..|               ||
Human   919 RLAAKK--------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

  Fly   858 RQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEH---IQRVNDFVASTFGSEQL-------- 911
            .|.| ||.||...|..::.......   |.:::.||.   .:|::|...:....|:.
Human   976 LQLE-KVTAEAKIKKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

  Fly   912 -KYQSFCTKFD---RHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHND--DL- 969
             |::|..::.:   :...|||.               :..|.|.:|..|..||    |..  ||
Human  1037 NKHESMISELEVRLKKEEKSRQ---------------ELEKLKRKLEGDASDF----HEQIADLQ 1082

  Fly   970 -MVIRIPLDLKKDKGDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQ 1032
             .:..:.:.|.|.:.:|...:.|:.:               .|..:|:....:.:.:|.:.|:|
Human  1083 AQIAELKMQLAKKEEELQAALARLDD---------------EIAQKNNALKKIRELEGHISDLQ 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	259/697 (37%)
		Myosin_TH1	863..1049	CDD:461801	34/189 (18%)
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951	259/697 (37%)
		Actin-binding. /evidence=ECO:0000250	668..690		9/21 (43%)
		Actin-binding. /evidence=ECO:0000250	769..783		5/14 (36%)
		Myosin_tail_1	855..1935	CDD:460256	55/326 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979