Protein Alignment Myo61F and MYH10

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_011522177.1
• Gene: MYH10 / 4628
• HGNCID: 7568
• Length: 2037
• Species: Homo sapiens
• Alignment Length: 1063
• Identity: 330/1063 - (31%)
• Similarity: 526/1063 - (49%)
• Gaps: 211/1063 - (19%)

  Fly    50 SEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNA 114
            :|.:.:.|||.|:...|||||.|...:.:||||.||||:::.::.||.|..:||||||:|::::|
Human   127 NEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESA 191

  Fly   115 FRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKD---------------- 163
            :|.::::...|.:|.:||||:||||.:|||:|::|..:.:.   :|.||
Human   192 YRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSH---KGRKDHNIPQESPKPVKHQGE 253

  Fly   164 ---KLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
               :||::||:||:||||||.:|||||||||::.|.||..|..:|.||..|||||||.|.|...|
Human   254 LERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDE 318

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDG---LNGTVTRINDADSFKQVQQALTVIDF 287
            |.||||||||:||.|.|..:|.|| ..:.|.:|::|   :.|.    .|.|:|::..:|:.::.|
Human   319 RTFHIFYQLLSGAGEHLKSDLLLE-GFNNYRFLSNGYIPIPGQ----QDKDNFQETMEAMHIMGF 378

  Fly   288 TKEEQREIFGIVASILHLGNVGFTEVEGN---AKVNSRDLVVTAARLLGVNASELEAALTHRTID 349
            :.||...:..:|:|:|..||:.|.: |.|   |.:....:......|||:|..|...|:....|.
Human   379 SHEEILSMLKVVSSVLQFGNISFKK-ERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIK 442

  Fly   350 ARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEI 414
            ...|.|.....:|.|.:|.:|||||.|:|||.|||.|:|.:|.  .|:....:.:|||||.||||
Human   443 VGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALD--RTKRQGASFIGILDIAGFEI 505

  Fly   415 FQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVICNLIEE--KHKG 476
            |:.|||||.|||:.||||||||.......||:||:||||||..::: .|.:...:|||.  ...|
Human   506 FELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPG 570

  Fly   477 IISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYS 541
            ::::|||||..| :.|||||:|||.|:...|..:    :.|..:|.   :.:|.::||||:|.|.
Human   571 VLALLDEECWFP-KATDKTFVEKLVQEQGSHSKF----QKPRQLKD---KADFCIIHYAGKVDYK 627

  Fly   542 VNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPE--------------------- 585
            .:.:|.||.|.|..::...|.::.:..|...:.: |:::::|..
Human   628 ADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKD-EIQNIQRASFYDSVSGLHEPPVDRIVGLDQ 691

  Fly   586 -TAITQ--------------------FRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELV 629
             |.:|:                    ::.||..||..|....|:::|||.||..:.|...:..||
Human   692 VTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLV 756

  Fly   630 LHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDE 694
            |.|::..|::|.:|:.|.||..|..::.|.:||:.|:.:..|  ||....|...:::::.|..|.
Human   757 LDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIP--KGFMDGKQACERMIRALELDP 819

  Fly   695 EKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRR 759
            ..||:|::|:|.|                    |.:.||    ::..:.||:...:|..|:.||.
Human   820 NLYRIGQSKIFFR--------------------AGVLAH----LEEERDLKITDIIIFFQAVCRG 860

  Fly   760 KLAQQA-AKKRREAA------------------------DKIRAFIKGFITRNDAPNGFNEEFIA 799
            .||::| |||:::.:                        .|::..::  :||.:      ||.
Human   861 YLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQ--VTRQE------EEL-- 915

  Fly   800 NAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQ-KRQFELK 863
            .||...||:: ||..|||               .|.|..:.|.|...:....:..:| :.:.||.
Human   916 QAKDEELLKV-KEKQTKV---------------EGELEEMERKHQQLLEEKNILAEQLQAETELF 964

  Fly   864 VLAEKV---FKGKKNNYASSVSTWFQEDRIPKE----------------HIQRVNDFVASTFGSE 909
            ..||::   ...||......:..  .|.|:.:|                |||.:.:.:....|:.
Human   965 AEAEEMRARLAAKKQELEEILHD--LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 1027

  Fly   910 QLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKI---------------D 959
            | |.|......:....|..:..:||.::     :.|..|:| :|..|:|               :
Human  1028 Q-KLQLEKVTAEAKIKKMEEEILLLEDQ-----NSKFIKEK-KLMEDRIAECSSQLAEEEEKAKN 1085

  Fly   960 FTLTNHNDDLMVIRIPLDLKKDK 982
            .....:..::|:..:...|||::
Human  1086 LAKIRNKQEVMISDLEERLKKEE 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	267/739 (36%)
		MYSc_Myo1	52..707	CDD:276829	265/724 (37%)
		Myosin_TH1	863..1035	CDD:283635	27/154 (18%)
MYH10	XP_011522177.1	Myosin_N	64..102	CDD:280832
		Myosin_head	117..832	CDD:278492	266/726 (37%)
		MYSc_Myh10	129..832	CDD:276952	265/724 (37%)
		Myosin_tail_1	909..1989	CDD:279860	47/233 (20%)
		DUF342	<1105..1194	CDD:302792	2/4 (50%)
		DUF2317	<1172..1283	CDD:302887
		COG5134	<1399..1527	CDD:227463
		GBP_C	<1565..1671	CDD:303769
		coiled coil	1661..1671	CDD:293879
		DUF106	<1706..>1757	CDD:303007
		DUF2570	1834..>1928	CDD:305162

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910