DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo61F and MYH8

DIOPT Version :9

Sequence 1:NP_476934.2 Gene:Myo61F / 38153 FlyBaseID:FBgn0010246 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_002463.2 Gene:MYH8 / 4626 HGNCID:7578 Length:1937 Species:Homo sapiens


Alignment Length:893 Identity:294/893 - (32%)
Similarity:465/893 - (52%) Gaps:102/893 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:: .:..|...:.|||:|:...:||||.|...::|||||.||:|..:.|.|||.|...|.
Human    90 IEDMAMM-THLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEA 153

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIA--ACSGNQTTVEG------ 160
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|  |.:|.:...|.      
Human   154 PPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKDESGKMQGT 218

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
            ::|:::.:||:|||||||||.||||||||||::.|.|...|.....:|..||||||||..|:..|
Human   219 LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAE 283

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            |::|||||:.:.....|::.|.:......|::::.| ..||..|:|.:.......|:.::.||.|
Human   284 RSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQG-EITVPSIDDQEELMATDSAIDILGFTPE 347

  Fly   291 EQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGD 353
            |:..|:.:..:::|.||:.|.:.  |..|:.:..::...||.|..:|:::|..||.:..:....:
Human   348 EKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNE 412

  Fly   354 VVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKN 418
            .||.....:....|..|||||||:::|.|:|.|:|   |..:|:..|...:|:|||.|||||..|
Human   413 YVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRIN---QQLDTKQPRQYFIGVLDIAGFEIFDFN 474

  Fly   419 SFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDE 483
            |.||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||.|||:|
Human   475 SLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEE 539

  Fly   484 ECLRPGEPTDKTFLEKL-TQKLAQHHHY----VCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVN 543
            ||:.| :.||.:|..|| .|.|.:..::    |...||.||         |.|:||||.|.|::.
Human   540 ECMFP-KATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAH---------FSLIHYAGTVDYNIT 594

  Fly   544 GFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSL--------------------KRP---- 584
            |:||||.|.|            |..|...:.:..:::|                    |:.    
Human   595 GWLDKNKDPL------------NDTVVGLYQKSAMKTLASLFSTYASAEADSSAKKGAKKKGSSF 647

  Fly   585 ETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGF 649
            :|....||.:||.||..|....|.::|||.||:.:|......||||||::..|::|.:|:.|.||
Human   648 QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGF 712

  Fly   650 AYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFD 714
            ..|..|..|.:|||.|:.|..|..:.....||. ::|:..:..|..:|:.|.||:|.: ...|..
Human   713 PSRILYGDFKQRYKVLNASAIPEGQFIDSKKAS-EKLLASIDIDHTQYKFGHTKVFFK-AGLLGL 775

  Fly   715 TEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKL--RAQVII-----------------MQSYCRRK 760
            .|:...||..:|....||..:|.:.|.:|.|:  |.:.:.                 |:.:.:.|
Human   776 LEEMRDEKLAQIITRTQAVCRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIK 840

  Fly   761 LAQQAAKKRREAADKIRAF--IKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDK--S 821
            ...::|:..:|.|.....|  .|..:.:::|.....||     |.:.||:...:|..:|..:  |
Human   841 PLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEE-----KMVTLLKEKNDLQLQVQSEADS 900

  Fly   822 WPHAPGHCEEASGILHRLHRLHL-ARIYRLKLTPQQKRQFELKVLAEK 868
            ...|...||:..     .:::.| |:|..:....:::.:...::.|:|
Human   901 LADAEERCEQLI-----KNKIQLEAKIKEVTERAEEEEEINAELTAKK 943

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo61FNP_476934.2 MYSc 32..720 CDD:214580 260/719 (36%)
MYSc_Myo1 52..707 CDD:276829 256/693 (37%)
Myosin_TH1 863..1035 CDD:283635 2/6 (33%)
MYH8NP_002463.2 Myosin_N 38..75 CDD:280832
Myosin_head 90..769 CDD:278492 258/706 (37%)
MYSc_Myh8 102..769 CDD:276882 256/693 (37%)
Actin-binding 658..680 10/21 (48%)
Actin-binding 760..774 4/14 (29%)
Myosin_tail_1 849..1926 CDD:279860 21/105 (20%)
eIF-4B <1042..1099 CDD:283846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1146
COG6 1375..>1510 CDD:303003
DUF342 <1505..1581 CDD:302792
TMPIT 1741..>1828 CDD:285135
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.