Protein Alignment Myo61F and MYH7

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_000248.2
• Gene: MYH7 / 4625
• HGNCID: 7577
• Length: 1935
• Species: Homo sapiens
• Alignment Length: 1088
• Identity: 333/1088 - (30%)
• Similarity: 529/1088 - (48%)
• Gaps: 195/1088 - (17%)

  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:| .:..|.|.:.|||.|:...:||||.|...::|||||.||:||.:.|.|||.|...|.
Human    87 IEDMAML-TFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEA 150

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG-------NQTTVEG- 160
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|..:.       :|:..:|
Human   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGT 215

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
            ::|:::::||.|||||||||.||||||||||::.|.|...|.....:|..||||||||:.|:..|
Human   216 LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAE 280

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            |::|||||:|:.....||..|.:......|::::.| ..||..|:||:.......|..|:.||.|
Human   281 RDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQG-ETTVASIDDAEELMATDNAFDVLGFTSE 344

  Fly   291 EQREIFGIVASILHLGNVGF--TEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGD 353
            |:..::.:..:|:|.||:.|  .:.|..|:.:..:....:|.|:|:|:::|...|.|..:....:
Human   345 EKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNE 409

  Fly   354 VVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKN 418
            .||...|.:..|||..|||||||:|:|:|:|.|:|.:|   ||:..|...:|:|||.|||||..|
Human   410 YVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL---ETKQPRQYFIGVLDIAGFEIFDFN 471

  Fly   419 SFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDE 483
            ||||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||:|||:|
Human   472 SFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEE 536

  Fly   484 ECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDE--FRLVHYAGEVTYSVNGFL 546
            ||:.| :.||.||..||   ...|.....:.:.|.:||.   :.|  |.|:||||.|.|::.|:|
Human   537 ECMFP-KATDMTFKAKL---FDNHLGKSANFQKPRNIKG---KPEAHFSLIHYAGIVDYNIIGWL 594

  Fly   547 DKNNDLLFRDLKETLSKAGNGIVRNCFP---------EKELRSLKRP---ETAITQFRASLNNLM 599
            .||.|.|...:.....|:...::...|.         ||.....|:.   :|.....|.:||.||
Human   595 QKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLM 659

  Fly   600 DILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKS 664
            ..|....|.::|||.||:.::..|.::.||:||::..|::|.:|:.|.||..|..|..|.:||:.
Human   660 TNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 724

  Fly   665 LSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAI 729
            |:.:..|..:.....| |.::|:..|..|..:|:.|.||:|.: ...|...|:...|:...|...
Human   725 LNPAAIPEGQFIDSRK-GAEKLLSSLDIDHNQYKFGHTKVFFK-AGLLGLLEEMRDERLSRIITR 787

  Fly   730 IQAHWKGLMQRRKYLKL---RAQVII----------------MQSYCRRKLAQQAAKKRREAADK 775
            |||..:|::.|.:|.||   |..:::                |:.|.:.|...::|::.:|.|..
Human   788 IQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASM 852

  Fly   776 IRAF--IKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHR 838
            ...|  :|..:.:::|..                   |||..|::               .:|
Human   853 KEEFTRLKEALEKSEARR-------------------KELEEKMV---------------SLL-- 881

  Fly   839 LHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASS-------VSTWFQEDRIPKEHIQ 896
                            |:|...:|:|.||      ::|.|.:       :....|.:...||..:
Human   882 ----------------QEKNDLQLQVQAE------QDNLADAEERCDQLIKNKIQLEAKVKEMNE 924

  Fly   897 RVND--FVASTFGSEQLKYQSFCTKF----------------DRHGYKSR-----------DRFI 932
            |:.|  .:.:...:::.|.:..|::.                ::|..:::           |..|
Human   925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989

  Fly   933 LLSNKAIYVLDGKTYKQKHRLPLDKIDF------TLTNHN-------DDL-------MVIRIPLD 977
            ....|     :.|..::.|:..||.:..      |||...       |||       ..:|:.|:
Human   990 AKLTK-----EKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049

  Fly   978 LKKDK--GDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVK 1023
            ..|.|  |||.|....|::...               |:..|:..:.|
Human  1050 RAKRKLEGDLKLTQESIMDLEN---------------DKQQLDERLKK 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	262/678 (39%)
		Myosin_TH1	863..1049	CDD:461801	38/219 (17%)
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	333/1088 (31%)
		MYSc_Myh7	99..766	CDD:276881	262/678 (39%)
		Actin-binding	655..677		10/21 (48%)
		Actin-binding	757..771		4/14 (29%)
		SMC_prok_B	1173..1930	CDD:274008
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1907..1935