DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and MYH6

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_002462.2	Gene:	MYH6 / 4624	HGNCID:	7576	Length:	1939	Species:	Homo sapiens

Alignment Length:	1102	Identity:	332/1102 - (30%)
Similarity:	525/1102 - (47%)	Gaps:	221/1102 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:| .:..|.|.:.|||:|:...:||||.|...::|||||.||:|..:.|.|||.|...|.
Human    87 IEDMAML-TFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEA 150

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAA------------CSGNQT 156
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|:            .:.|:.
Human   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKG 215

  Fly   157 TVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQ 221
            |:|   |:::::||.|||||||||.||||||||||::.|.|...|.....:|..||||||||:.|
Human   216 TLE---DQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQ 277

  Fly   222 MGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVID 286
            :..|||:|||||:|:.....||..|.:......|::::.| ..:|..|:|::.......|..|:.
Human   278 LKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQG-EVSVASIDDSEELMATDSAFDVLG 341

  Fly   287 FTKEEQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTID 349
            ||.||:..::.:..:|:|.||:.|.:.  |..|:.:..:....:|.|:|:|:::|...|.|..:.
Human   342 FTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVK 406

  Fly   350 ARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEI 414
            ...:.||...:.:...|:..|||||||:::|:|:|.|:|.:|   ||:..|...:|:|||.||||
Human   407 VGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATL---ETKQPRQYFIGVLDIAGFEI 468

  Fly   415 FQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIIS 479
            |..|||||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||:|
Human   469 FDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMS 533

  Fly   480 ILDEECLRPGEPTDKTFLEKL-TQKLAQHHHYVCHEKAPAHIKKIMLRDE--FRLVHYAGEVTYS 541
            ||:|||:.| :.||.||..|| ...|.:.:::    :.|.:||.   :.|  |.|:||||.|.|:
Human   534 ILEEECMFP-KATDMTFKAKLYDNHLGKSNNF----QKPRNIKG---KQEAHFSLIHYAGTVDYN 590

  Fly   542 VNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPE----------KELRSLKRP---ETAITQFRA 593
            :.|:|:||.|.|...:.....|:...::...|..          |.....|:.   :|.....|.
Human   591 ILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALHRE 655

  Fly   594 SLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELF 658
            :||.||..|....|.::|||.||:.:...|.::.||:||::..|::|.:|:.|.||..|..|..|
Human   656 NLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF 720

  Fly   659 LERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKK 723
            .:||:.|:....|..:.....| |.::|:..|..|..:|:.|.||:|.:
Human   721 RQRYRILNPVAIPEGQFIDSRK-GTEKLLSSLDIDHNQYKFGHTKVFFK---------------- 768

  Fly   724 HEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKK---RREAADKIRAFIKGFIT 785
               |.::     ||::..:..:|...:..||:..|.:|.:...||   ||:|...|:..|:.|:.
Human   769 ---AGLL-----GLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMG 825

  Fly   786 RNDAPNGFNEEFIANAKRMW---------LLRLA---KELPT---------KVLDKSWPHAPGHC 829
            ..:.|              |         ||:.|   ||:.|         :.|:||
Human   826 VKNWP--------------WMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKS-------- 868

  Fly   830 EEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAE------------KVFKGKKNNYASSVS 882
             ||     |...|....:..|    |:|...:|:|.||            ::.|.|
Human   869 -EA-----RRKELEEKMVSLL----QEKNDLQLQVQAEQDNLNDAEERCDQLIKNK--------- 914

  Fly   883 TWFQEDRIPKEHIQRVND--FVASTFGSEQLKYQSFCTKF----------------DRHGYKSR- 928
              .|.:...||..:|:.|  .:.:...:::.|.:..|::.                ::|..:::
Human   915 --IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 977

  Fly   929 ----------DRFILLSNKAIYVLDGKTYKQKHRLPLD-------------KIDFTLTNHNDDL- 969
                      |..|....|     :.|..::.|:..||             |....|....|||
Human   978 KNLTEEMAGLDEIIAKLTK-----EKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLE 1037

  Fly   970 ------MVIRIPLDLKKDK--GDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVK 1023
                  ..:|:.|:..|.|  |||.|....|::...               |:..||..:.|
Human  1038 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN---------------DKLQLEEKLKK 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	259/710 (36%)
		MYSc_Myo1	52..707	CDD:276829	256/684 (37%)
		Myosin_TH1	863..1035	CDD:283635	38/224 (17%)
MYH6	NP_002462.2	Myosin_N	35..72	CDD:280832
		Myosin_head	87..768	CDD:278492	259/697 (37%)
		MYSc_class_II	99..768	CDD:276951	256/684 (37%)
		Actin-binding	657..679		10/21 (48%)
		Actin-binding	759..773		5/37 (14%)
		Myosin_tail_1	848..1925	CDD:279860	52/286 (18%)
		SPEC	881..1043	CDD:295325	29/181 (16%)
		MM_CoA_mutase	<1134..1295	CDD:294532
		MIT_CorA-like	<1297..>1409	CDD:294313
		TMPIT	1740..>1832	CDD:285135
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1826..1849
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1909..1939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910