DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and MYH2

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001093582.1	Gene:	MYH2 / 4620	HGNCID:	7572	Length:	1941	Species:	Homo sapiens

Alignment Length:	1109	Identity:	334/1109 - (30%)
Similarity:	526/1109 - (47%)	Gaps:	206/1109 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:: .:..|.|.:.|||:|:...:||||.|...::|||||.||:|..:.|.|||.|...|.
Human    88 IEDMAMM-THLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEA 151

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIA--ACSGNQT-------TVE 159
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|  |.:|.:.       .::
Human   152 PPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKIQ 216

  Fly   160 G-VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMG 223
            | ::|:::.:||:|||||||||.||||||||||::.|.|...|.....:|..|||||||||.|:.
Human   217 GTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVVFQLK 281

  Fly   224 GERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFT 288
            .||::|||||:.:.....|::.|.:......|.:::.| ..:|..|:|.:.......|:.::.||
Human   282 AERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQG-EISVASIDDQEELMATDSAIDILGFT 345

  Fly   289 KEEQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDAR 351
            .||:..|:.:..:::|.||:.|.:.  |..|:.:..::...||.|..:|:::|..||.:..:...
Human   346 NEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVG 410

  Fly   352 GDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQ 416
            .:.||.....|....|..|||||||:::|.|:|.|:|   |..:|:..|...:|:|||.|||||.
Human   411 NEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARIN---QQLDTKQPRQYFIGVLDIAGFEIFD 472

  Fly   417 KNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISIL 481
            .||.||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||.|||
Human   473 FNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSIL 537

  Fly   482 DEECLRPGEPTDKTFLEKL-TQKLAQHHHY----VCHEKAPAHIKKIMLRDEFRLVHYAGEVTYS 541
            :|||:.| :.||.:|..|| .|.|.:..::    |...||.||         |.|:||||.|.|:
Human   538 EEECMFP-KATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAH---------FALIHYAGVVDYN 592

  Fly   542 VNGFLDKNND--------LLFRDLKETLSK------------AGNGIVRNCFPEKELRSLKRPET 586
            :.|:|:||.|        |..:...:||::            ||.|..:.  .:|:..|.   :|
Human   593 ITGWLEKNKDPLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGAGGGAKKG--GKKKGSSF---QT 652

  Fly   587 AITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAY 651
            ....||.:||.||..|....|.::|||.||:.:|......||||||::..|::|.:|:.|.||..
Human   653 VSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPS 717

  Fly   652 RRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTE 716
            |..|..|.:|||.|:.|..|..:.....||. ::|:..:..|..:|:.|.||:|.:
Human   718 RILYADFKQRYKVLNASAIPEGQFIDSKKAS-EKLLASIDIDHTQYKFGHTKVFFK--------- 772

  Fly   717 DAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQ---QAAKKRREAADKIRA 778
                      |.::     ||::..:..||...:...|:.||..||:   |...:||||...|:.
Human   773 ----------AGLL-----GLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQY 822

  Fly   779 FIKGFITRNDAPNGFNEEFIANAKRMW---------LLRLA---KELPTKVLDKSWPHAPGHCEE 831
            .|:.|:.....|              |         ||:.|   ||:.|..            ||
Human   823 NIRSFMNVKHWP--------------WMKLFFKIKPLLKSAETEKEMATMK------------EE 861

  Fly   832 ASGILHRLHRLHLAR-------IYRLKLTPQQKRQFELKVLAE-KVFKGKKNNYASSVSTWFQED 888
            ...|...|.:....|       :..||    :|...:|:|.|| :.....:......:.|..|.:
Human   862 FQKIKDELAKSEAKRKELEEKMVTLLK----EKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLE 922

  Fly   889 RIPKEHIQRVND--FVASTFGSEQLKYQSFCTKF----------------DRHGYKSR------- 928
            ...||..:|..|  .:.:...:::.|.:..|::.                ::|..:::
Human   923 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 987

  Fly   929 ----DRFILLSNKAIYVLDGKTYKQKHRLPLD-------------KIDFTLTNHNDDL------- 969
                |..|....|     :.|..::.|:..||             |....|....|||
Human   988 MAGLDETIAKLTK-----EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE 1047

  Fly   970 MVIRIPLDLKKDK--GDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQ 1032
            ..:|:.|:..|.|  |||.|....|::...               ::..|:..:.|.:..:.::|
Human  1048 KKLRMDLERAKRKLEGDLKLAQESIMDIEN---------------EKQQLDEKLKKKEFEISNLQ 1097

  Fly  1033 TGAE 1036
            :..|
Human  1098 SKIE 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	262/717 (37%)
		MYSc_Myo1	52..707	CDD:276829	260/691 (38%)
		Myosin_TH1	863..1035	CDD:283635	36/223 (16%)
MYH2	NP_001093582.1	Myosin_N	36..73	CDD:280832
		Myosin_head	88..772	CDD:278492	262/704 (37%)
		MYSc_Myh2_mammals	100..772	CDD:276877	260/691 (38%)
		Actin-binding. /evidence=ECO:0000250	661..683		10/21 (48%)
		Actin-binding. /evidence=ECO:0000250	763..777		5/37 (14%)
		Myosin_tail_1	852..1929	CDD:279860	49/286 (17%)
		RILP-like	967..1100	CDD:304877	25/152 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1128..1149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1155..1174
		DUF342	<1672..1769	CDD:302792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910