DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo61F and MYO1F

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_011526326.1	Gene:	MYO1F / 4542	HGNCID:	7600	Length:	1119	Species:	Homo sapiens

Alignment Length:	1025	Identity:	361/1025 - (35%)
Similarity:	510/1025 - (49%)	Gaps:	211/1025 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MDTKDYIDFNSQLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLIS 77
            |.:|:...:.|        |...::||.|.|||... :|:|...||:|||.:|.|:||||.||||
Human     1 MGSKERFHWQS--------HNVKQSGVDDMVLLPQI-TEDAIAANLRKRFMDDYIFTYIGSVLIS 56

  Fly    78 VNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASK 142
            |||:||:|.:||..:..|:....||.||||:|:|||.:|:::.:...|||:||||||:|||.|:|
Human    57 VNPFKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAK 121

  Fly   143 KVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGN 207
            .::.:|:..||....|:.|||.:|:|||:|||||||||.||:||||||||.:|||...|.|.||.
Human   122 YIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGK 186

  Fly   208 ILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDA 272
            |.|:||||||||.|...||||||:||||.||.:...|.|.| ...|.|.||.......|...:|.
Human   187 ISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGL-MTPDYYYYLNQSDTYQVDGTDDR 250

  Fly   273 DSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGN-AKVNSRDLVVTAARLLGVNA 336
            ..|.:...|:.||......|:.:..:||.||||||:.|.| :|| |:|.|.||:...|.|||:::
Human   251 SDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCE-DGNYARVESVDLLAFPAYLLGIDS 314

  Fly   337 SELEAALTHRTIDA----RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETR 397
            ..|:..||.|.:|:    |.:.:...||.|.|.|.||||||.:|.|||.:||:.:|.::|..:..
Human   315 GRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEE 379

  Fly   398 ASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFD 462
            .|    :|:||||||||||||.||||||||.||||||:|||||||:||:||.:|||.|.|::||:
Human   380 YS----IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFN 440

  Fly   463 NKVICNLIEEK--HKGIISILDEECL---RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKK 522
            |||:|:|||.|  ..||:|:||:.|.   ..|...|:|.|:||...:..|.|:......
Human   441 NKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWSAG------ 499

  Fly   523 IMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLK-RPET 586
                  |.:.||||:|:|.|:||.::|.|:||.||.|.:..:....:|..||||.....| ||.|
Human   500 ------FVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLDGDKKGRPST 558

  Fly   587 AITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELV------------LHQV------ 633
            |.::.:...|:|:..||...|.||||||||:.:....:.:...            .||.
Human   559 AGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENRTGDSPPRGDSAYPPHQSQAPGGI 623

  Fly   634 -----KYLGLMENLR----VRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKD 689
                 ::.|....||    ||:.      ..|....||..|:..|||.::  |..:.|||.|::.
Human   624 PGPEGEHQGAQSRLRLPPPVRQI------PAEPSALRYAILTPETWPRWR--GDERQGVQHLLRA 680

  Fly   690 LGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQ 754
            :..:.::|::|.||:|::.|.:||..|:..:.|....|..||..|:..:..|||.::|
Human   681 VNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMR------- 738

  Fly   755 SYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLD 819

Human   739 ----------------------------------------------------------------- 738

  Fly   820 KSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTW 884
                      ||||.||                                  ..||....:|::..
Human   739 ----------EEASNIL----------------------------------LNKKERRRNSINRN 759

  Fly   885 FQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYK- 948
            |..|.:..|....:..|:..   .|::.:....||:||. :|...|.::|:.|.:||:..:..|
Human   760 FVGDYLGLEERPELRQFLGK---RERVDFADSVTKYDRR-FKPIKRDLILTPKCVYVIGREKVKK 820

  Fly   949 -----QKHRLPLDKIDF------TLTNHNDDLMVIRIPLDLKKDKGDLIL 987
                 |...:...|:|.      :|:...||..:      |::|..|..|
Human   821 GPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFI------LQEDAADSFL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	314/725 (43%)
		MYSc_Myo1	52..707	CDD:276829	302/692 (44%)
		Myosin_TH1	863..1035	CDD:283635	29/137 (21%)
MYO1F	XP_011526326.1	MYSc	12..711	CDD:214580	314/725 (43%)
		MYSc_Myo1	31..698	CDD:276829	302/692 (44%)
		Myosin_TH1	738..918	CDD:283635	36/253 (14%)
		SH3_MyoIe_If_like	1066..1118	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820