Protein Alignment Myo61F and myo6b

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001004110.1
• Gene: myo6b / 445472
• ZFINID: ZDB-GENE-030318-3
• Length: 1267
• Species: Danio rerio
• Alignment Length: 931
• Identity: 299/931 - (32%)
• Similarity: 473/931 - (50%)
• Gaps: 114/931 - (12%)

  Fly    48 YQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLP-IYTDDHVKAYRNKHFYEMPPHIFAVT 111
            |.:|...:.|::.|:.:|:|||::..:||:||||..:| :|:.:.:|:|:.:....:|||::|:.
Zfish    67 YLNEATLLNNIRIRYSKDMIYTFVANILIAVNPYFDIPKLYSPESIKSYQGRSLGTLPPHVYAIA 131

  Fly   112 DNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFG 176
            |.|:|.:......|.:::|||||:||||.:|.||:::....|   |.:.:.::::::||:|||||
Zfish   132 DKAYRDMRVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYG---TGQDIDERIVEANPLLEAFG 193

  Fly   177 NAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEA 241
            ||||.||:|||||||:::|.|:.|.|.:||.:.:|||||||:..|...|||:||||:|.|||.|.
Zfish   194 NAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICMQSQEERNYHIFYRLCAGASED 258

  Fly   242 LLQELRLERALDTYSYLTDGLNGTVTR-INDADSFKQVQQ------------------------- 280
            :...|.| .:.|::.||..|    .|| ..:.||.||:.|
Zfish   259 IRNMLHL-NSPDSFRYLNRG----CTRYFANKDSDKQIMQNXKSPEDHKHGKVGALKDPLLDDLG 318

  Fly   281 -------ALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNA-----KVNSRDLVVTAARLLG 333
                   |:..|.....|:..:|.:||.:|||||:.|.|....:     |..|...:...|.|||
Zfish   319 DFNRMVVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDFEETGSTSGGCILKNQSSQTLEYCADLLG 383

  Fly   334 VNASELEAALTHRTI-----DARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQA 393
            ::..:|..:||.|.:     .|:|.|:..||..|.|..||||||||||.|||..:|:|:|.....
Zfish   384 LDQDDLRVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARDALAKAVYSRLFDHVVKRVNQCFPF 448

  Fly   394 KETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPV 458
            .    :.:|.:|:.||.|||.|:.|||||||||:|||||||.|.|..||.||:.|:|||:....|
Zfish   449 D----TSSNFIGVPDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQREGLGVNEV 509

  Fly   459 EYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKI 523
            .|.||:...:|:|.|..|::.|||||...| :|:|:.|.|.:..|...|.......|:...|.:.
Zfish   510 HYVDNQDCIDLVEAKLVGVLDILDEENRLP-QPSDQHFAEAVHSKHKDHFRLTVPRKSKLTIHRN 573

  Fly   524 MLRDE-FRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETA 587
            :..|| |.:.|:||.|.|....|::||||.|...|:..:.::.:..||:.| |....|....:.|
Zfish   574 LRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLVCESKDKFVRDLF-ENNSNSKDSKQKA 637

  Fly   588 --------ITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRV 644
                    ..:|:..||.|::.|.....|:|||:|||....::.|....:|.|::..|::..|.:
Zfish   638 GKLSFISVGNKFKTQLNLLLEKLRSTGSSFIRCVKPNLKMVSHQFEGAQILSQLQCSGMVSVLDL 702

  Fly   645 RRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWP 709
            .:.||..|..:......||..    .||......|:...:.|.|.||.:|..|:.|.|::|.| |
Zfish   703 MQGGFPSRAPFHELYNMYKQY----MPNKLTRLDPRLFCKALFKALGLNENDYKFGLTRVFFR-P 762

  Fly   710 RTLFDTEDAYQEKKHEIAAIIQ--------AHWK-------GLMQRRKYLKLRAQVII-MQSYCR 758
            ....:.:...:.....:|.:::        :.||       .:::.|..:..||...| :|...|
Zfish   763 GKFAEFDQIMKSDPDHLAELVKRVNKWLVCSRWKKVQWCTLSVIKLRNKMSYRASACIRIQKTVR 827

  Fly   759 RKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLL-----RLAKELPTKVL 818
            ..|.::..|.|.:...|::...|.....|:|.||..|.....:|::..|     .|..::.|.|:
Zfish   828 MWLCRRRHKPRVDGLVKVKNLRKRMERFNEAVNGLKEGKAEMSKQIEELAASTDALMAKIKTTVM 892

  Fly   819 DKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFE------LKVLAEKVFK-GKKNN 876
            .:....     :|..|::.|..:|         |:..||::.|      ||.:.|::.| .|::.
Zfish   893 SRKEIE-----QEYEGLVKRSEQL---------LSSMQKKKQEQEETERLKHIQEZMEKERKRHE 943

  Fly   877 YASSVSTWFQEDRIPKEHIQR 897
            ....:....:|||..|..:::
Zfish   944 EEEQLRKQEEEDRRMKSEMEQ 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	254/707 (36%)
		Myosin_TH1	863..1049	CDD:461801	8/36 (22%)
myo6b	NP_001004110.1	Myosin_N	2..>32	CDD:460670
		MYSc_Myo6	71..761	CDD:276833	254/707 (36%)
		CBD_MYO6-like	772..919	CDD:409646	31/160 (19%)
		DUF4670	<872..1032	CDD:464815	21/107 (20%)
		MYO6_MIU_linker	1001..1081	CDD:412090
		MyUb_Myo6	1064..1104	CDD:439319
		Myosin-VI_CBD	1150..1240	CDD:465157