Protein Alignment Myo61F and MYO1B

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001123630.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1136
• Species: Homo sapiens
• Alignment Length: 1107
• Identity: 467/1107 - (42%)
• Similarity: 660/1107 - (59%)
• Gaps: 155/1107 - (14%)

  Fly    23 SQLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIY 87
            ::::::|.|.: :..||.|.||||.. :||.||.||||||....||||||.|:||||||:.||||
Human     2 AKMEVKTSLLD-NMIGVGDMVLLEPL-NEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIY 64

  Fly    88 TDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACS 152
            :.:.|:.|||::|||:.|||||::|.|:|||.::::.||:||:||||:|||||||.|:.::||..
Human    65 SPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVC 129

  Fly   153 GNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSR 217
            |....|..||::||:|||||||||||||.||||||||||||||:|||||.|:||.|.||||||||
Human   130 GKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSR 194

  Fly   218 VVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLT-DGLNGTVTRINDADSFKQVQQA 281
            ||.|..||||||:|||||:||.|.||.:|:|||....|:||: |  :..|..::||.:|:.|:.|
Human   195 VVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLD--SAKVNGVDDAANFRTVRNA 257

  Fly   282 LTVIDFTKEEQREIFGIVASILHLGNVGF---TEVEG--NAKVNSRDLVVTAARLLGVNASELEA 341
            :.::.|...|...:..:||::|.|||:.|   :.|.|  .:|:..::.:.....|.|::.|.||.
Human   258 MQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLER 322

  Fly   342 ALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGI 406
            |.:.||::|:.:.|::.||...|.||||||||.:|.|||||||.|:|.|::| :|:. |..|||:
Human   323 AFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKA-QTKV-RKKVMGV 385

  Fly   407 LDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIE 471
            |||||||||:.||||||.||:|||||||:|||||||.||:||.||.|||..::||:|.:||:|||
Human   386 LDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIE 450

  Fly   472 EKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCH-EKAPAHIKKIMLRDE-FRLVHY 534
            ....||:::|||||||||..||:||||||.|..|.|.|:... .|....:....|... ||:.||
Human   451 NNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHY 515

  Fly   535 AGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELR--SLKRPETAITQFRASLNN 597
            ||:|.|.|.||:|||||||:|||.:.:.||.:.::::.|||....  :||||.||.:||:||:..
Human   516 AGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVAT 580

  Fly   598 LMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERY 662
            ||..|..|.|:|||||||||.:.|::||:.||.||::||||:||:||||||:|:|:.||..||||
Human   581 LMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERY 645

  Fly   663 KSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIA 727
            |.|.|.|||::|||.  ::||:.|..:|....|:|..|.:|:|||.|||||..||..:::..::|
Human   646 KMLCKQTWPHWKGPA--RSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLA 708

  Fly   728 AIIQAHWKG--------LM---------------QRRKYLKLRAQVIIMQSYCR----------- 758
            .:||..::|        ||               |:::|.:.::..:::|||.|
Human   709 TLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILREL 773

  Fly   759 --------------------------RKLAQQAAKK---------------------------RR 770
                                      |:|.::|..|                           |:
Human   774 KHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWLGSKARRELKRLKEEARRK 838

  Fly   771 EAADKIRAFIKGFITRNDAPNGFNEEFIANAKR------------MWLLRLAKELPT-KVLDKSW 822
            .|...|.|:..|...|.:    :.:.|.|||.:            .:.|.:..::|: ..:||:|
Human   839 HAVAVIWAYWLGLKVRRE----YRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNW 899

  Fly   823 PHAP------GHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSV 881
            |..|      .|.|     |.|:..|...:.||.:.|.|||..:|.|:.|.::||.||..|.|||
Human   900 PSRPYLFLDSTHKE-----LKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSV 959

  Fly   882 STWFQE-----DRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYV 941
            ...||.     ::.||  .:::.|.:     .|::.......|.:|...||..|..||:|..:.:
Human   960 GQPFQGAYLEINKNPK--YKKLKDAI-----EEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLL 1017

  Fly   942 LDGKTYKQKHRLPL-DKIDFTLTNHNDDLMVIRIPLDLKK-----DKGDLILIIPRIIEFSTYII 1000
            .|.|:.:.|..:|| |....::::.||....:.    ||:     .|||.:.....:||.:|.:.
Human  1018 ADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVH----LKEGSEAASKGDFLFSSDHLIEMATKLY 1078

  Fly  1001 DT 1002
            .|
Human  1079 RT 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	379/697 (54%)
		MYSc_Myo1	52..707	CDD:276829	362/664 (55%)
		Myosin_TH1	863..1035	CDD:283635	41/151 (27%)
MYO1B	NP_001123630.1	MYSc_Myo1	29..688	CDD:276829	362/664 (55%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	578..600		12/21 (57%)
		IQ	749..771	CDD:197470	4/21 (19%)
		Myosin_TH1	941..1118	CDD:399188	41/151 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720