DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo1a

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001074688.1	Gene:	Myo1a / 432516	MGIID:	107732	Length:	1043	Species:	Mus musculus

Alignment Length:	1054	Identity:	462/1054 - (43%)
Similarity:	657/1054 - (62%)	Gaps:	75/1054 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            ||:|.:|||.. .||:.|.||:.|::...||||||.|:||:|||:|||||..:.:..||:..|||
Mouse     9 GVEDLILLEPL-DEESLIKNLQLRYENKEIYTYIGNVVISMNPYEQLPIYGPEFIAKYRDYTFYE 72

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLK 167
            :.|||:|:.:.|::||.:.:|.||:||:||||:|||||||.|:.::||..|....|..||::||:
Mouse    73 LKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQ 137

  Fly   168 SNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFY 232
            |||||||||||||.||:|||||||||||:|||||:|:||.|.||||||||||.|:.|||||||||
Mouse   138 SNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNFHIFY 202

  Fly   233 QLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRIN---DADSFKQVQQALTVIDFTKEEQRE 294
            |||||||..||:.|:||.....|.|    |||.|:::|   ||.:|:.||.|::||.|::||.|:
Mouse   203 QLLAGADAQLLKALKLEEDTSVYGY----LNGEVSKVNGMDDASNFRAVQHAMSVIGFSEEEIRQ 263

  Fly   295 IFGIVASILHLGNVGFT-EVEGN----AKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGDV 354
            :..:.|.:|.||||..| |.:.|    :.:.....:.....::|:|::|||.||..||::...:.
Mouse   264 VLEVTALVLKLGNVKLTDEFQANGIPASGICDGKGIQEIGEMMGLNSTELERALCSRTMETGKEK 328

  Fly   355 VTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNS 419
            |.:.||...|.||||||||.:|.|||.|:|:|:|.|:  |.....:..|||:||||||||.:.||
Mouse   329 VVTVLNVTQAQYARDALAKNIYSRLFDWIVKRINESI--KVGTGEKKKVMGVLDIYGFEILEDNS 391

  Fly   420 FEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEE 484
            ||||.||:|||:|||:|||||||.||:||:||||.|..||||||.:||||||...:||:::||||
Mouse   392 FEQFVINYCNERLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICNLIEHSQRGILAMLDEE 456

  Fly   485 CLRPGEPTDKTFLEKLTQKLAQHHHY--VCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLD 547
            |||||..:|.|||.||.|..::|.||  ...:.|.....:.|....||:.||||:|||:|.||:|
Mouse   457 CLRPGVVSDSTFLAKLNQLFSKHSHYESKVSQNAQRQYDRTMGLSCFRISHYAGKVTYNVTGFID 521

  Fly   548 KNNDLLFRDLKETLSKAGNGIVRNCFPE---KELRSLKRPETAITQFRASLNNLMDILMCKEPSY 609
            ||||||||||.:|:.||.:.::::.|||   || .|||||.||.|||:.|:..||..|..|.|:|
Mouse   522 KNNDLLFRDLSQTMWKAQHPLLKSLFPEGNPKE-ASLKRPPTAGTQFKNSVAVLMKNLYSKNPNY 585

  Fly   610 IRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYK 674
            ||||||||.|....|..|:|:.|.:||||:||:||||||:|:|:.|:.|||||:.||:||||.:.
Mouse   586 IRCIKPNDQQQKGRFTSEMVMVQARYLGLLENVRVRRAGYAFRQGYKPFLERYRLLSRSTWPRWN 650

  Fly   675 GPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQ 739
              |..:.||::::..|....|:...|:||:|||.|:|||..|:..:.:..::|.:||..::|...
Mouse   651 --GDDREGVEKVLGSLTLSSEELAYGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKVYRGWRC 713

  Fly   740 RRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNE-------EF 797
            |..|.::|...|::.::.|....::...|.|.:...|:||::|:..|.:....|..       .|
Mouse   714 RTHYQQMRKSQILISAWFRGNKQKKHYGKIRSSVLLIQAFVRGWRARKNYRKYFRSGAALTLANF 778

  Fly   798 I-ANAKRMWLLRLAKELP-TKVLDKSWPHAPGHC-EEASGILHRLHRLHLARIYRLKLTPQQKRQ 859
            | .:..:.:||.|.|.|| |||||.:||.||..| ..|:..|.||......:.:|.:|:|:|.:.
Mouse   779 IYQSMAQKFLLNLKKNLPSTKVLDNTWPAAPYRCFNTANQELQRLFYQWKCKKFRDQLSPKQVQT 843

  Fly   860 FELKVLAEKVFKGKKNNYASSVSTWFQEDRI-----PKEHIQRVND------FVASTFGSEQLKY 913
            ...|:.|.::|||||.:|..||...|:.|.|     ||  :||:..      .||.|
Mouse   844 LREKLCASELFKGKKASYPQSVPIPFRGDYIGLQGNPK--LQRLKGREEGPVLVADT-------- 898

  Fly   914 QSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKI-DFTLTNHNDDLMVIRI-PL 976
               ..|.:|...|:..|.:||:...:.:.|.|..:.:..:.|:.: ..::::..|.|..:.: .:
Mouse   899 ---VKKVNRGNGKTSARILLLTKGHVILTDAKKSQAQIVIGLEDVAGVSVSSLQDGLFSLHLSEM 960

  Fly   977 DLKKDKGDLILIIPRIIEFST----YIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQT--GA 1035
            .....|||::|:...::|..|    .::|.......|::.::.|     |:.|.|.:.::.  |.
Mouse   961 SSAVSKGDILLVSDHVVELLTKMYQAVLDATQRQLSVTVTEKFS-----VRFKEGSVAVKVIQGP 1020

  Fly  1036 EPG-----VVRDKG 1044
            |.|     :.:.||
Mouse  1021 EGGGNRKLICKKKG 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	371/694 (53%)
		MYSc_Myo1	52..707	CDD:276829	357/667 (54%)
		Myosin_TH1	863..1035	CDD:283635	43/190 (23%)
Myo1a	NP_001074688.1	MYSc_Myo1	22..681	CDD:276829	357/667 (54%)
		Actin-binding. /evidence=ECO:0000255	571..593		12/21 (57%)
		IQ	742..764	CDD:197470	7/21 (33%)
		Myosin_TH1	847..1042	CDD:368706	48/206 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720