Protein Alignment Myo61F and jar

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Alignment Length: 890
• Identity: 288/890 - (32%)
• Similarity: 453/890 - (50%)
• Gaps: 100/890 - (11%)

  Fly    50 SEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQL-PIYTDDHVKAYRNKHFYEMPPHIFAVTDN 113
            :|..|:.|||.|:.:|.||||:..:||:||||::: .:|..|.:|.|..:...|:|||:||:.|.
  Fly    69 NEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADK 133

  Fly   114 AFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNA 178
            |.|.:......|.:::|||||:||||::|.:|:::.....:...:|   .|:|.:||||||||||
  Fly   134 AIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIE---TKILDANPVLEAFGNA 195

  Fly   179 KTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALL 243
            ||.||:|||||||::::.:|.|...:||.|.:|||||||:..|...|||:|:||.|||||.:.|.
  Fly   196 KTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLR 260

  Fly   244 QELRLERALDTYSYL---TDGLNGTVTR----------------------INDADSFKQVQQALT 283
            .:|.|.:. |.|.||   |.......|.                      |:|...|..:.:||.
  Fly   261 DKLSLGKP-DDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALG 324

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGFTE----VEGNAKV---NSRDLVVTAARLLGVNASELEA 341
            .:..:..|:..|:.:||::|||||:.|.|    |.|..:|   :.:.|.:|:. ||||:.:||..
  Fly   325 RLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSG-LLGVDQTELRT 388

  Fly   342 ALTHRTIDA-----RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRN 401
            ||..|.:.:     :|.|:..||....|..||||||||:|.|||..:|..:|.|:..:    :.|
  Fly   389 ALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQ----ASN 449

  Fly   402 NVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVI 466
            ..:|:|||.|||.|..|||||||||:||||||:.|.:..||:||:.|:|||:....:.:.||:.|
  Fly   450 FYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDI 514

  Fly   467 CNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVC--HEKAPAHIKKIMLRDE- 528
            ..|||.|..||.::||||...| :|:...|..::.:..|.|:....  ..:..||   ..||||
  Fly   515 IELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWANHYRLGLPRSSRLKAH---RTLRDEE 575

  Fly   529 -FRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAI---T 589
             |.:.|:||.|.|:...|::||||.|...|:..:.:..|.:::..||.....|::.....|   :
  Fly   576 GFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNFISVGS 640

  Fly   590 QFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRT 654
            :|:..|..||:.|.....::|||||||.......|...|.|.|:|..|.:..|.:...|:..|
  Fly   641 KFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSR-- 703

  Fly   655 YELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAY 719
             .||.:.| |:.||..|........:...:.:.:.|....:.::.|.||:|.| |....:.:...
  Fly   704 -VLFADLY-SMYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFR-PGKFVEFDRIM 765

  Fly   720 QEKKHEIAAI--------IQAHW-KGLMQRRKYLKLRAQVI-------IMQSYCRRKLAQQAAKK 768
            :.....:.||        |::.| |..:.....:|||.::|       |.|...|..||::..:.
  Fly   766 RSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRP 830

  Fly   769 RREAADKIRAFIKGFITRNDAPNGF---NEEFIANAKRMW--------LLRLAKELPTKVLDKSW 822
            |.:...||.......:...:..:|.   .||.|:....::        .:::...:..:.:|..:
  Fly   831 RYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMY 895

  Fly   823 PHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAE 867
                      :.::..:::|.:....:||...|.:.|..|:.:.|
  Fly   896 ----------TVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQE 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	256/699 (37%)
		Myosin_TH1	863..1049	CDD:461801	1/5 (20%)
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	256/699 (37%)
		CBD_MYO6-like	765..913	CDD:409646	23/157 (15%)
		ERM_helical	<954..1020	CDD:466641
		MYO6_MIU_linker	1002..1093	CDD:480843
		MyUb_Myo6	1076..1116	CDD:439319
		Myosin-VI_CBD	1160..1246	CDD:465157