Protein Alignment Myo61F and myo3a

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_068073147.1
• Gene: myo3a / 402814
• ZFINID: ZDB-GENE-041026-4
• Length: 1790
• Species: Danio rerio
• Alignment Length: 1160
• Identity: 340/1160 - (29%)
• Similarity: 547/1160 - (47%)
• Gaps: 272/1160 - (23%)

  Fly    17 DYIDFNSQLKM--ETGL-----------HER--------------------DRAGVQDFVLLENY 48
            :.||.|.|:.:  :|.|           |||                    |.|.::  ||.||.
Zfish   318 ELIDLNQQMGIIEKTSLLGKSDRDSDSRHERIHTKKNSYMKSQSQTCDDADDLATLE--VLDENT 380

  Fly    49 QSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDN 113
            .:|:     |::|:.::.||||:|.:||:|||:.:..:||.:|.|:|........||||:||.|.
Zfish   381 ITEQ-----LQRRYTKEQIYTYVGDILIAVNPFHKTELYTPEHTKSYVGAKRTSNPPHIYAVADI 440

  Fly   114 AFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG------VKDKLLKSNPVL 172
            |::|::..|..||::||||||:||||::..::|        |.||.|      :::|:|..|.::
Zfish   441 AYQSMVSYNADQCIVISGESGAGKTESAHLLVQ--------QLTVLGKANNRTLQEKILLVNSLV 497

  Fly   173 EAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAG 237
            ||||||.|..||||||||||::::|...|..:|..|.:|||||||||....|||||||||.:.||
Zfish   498 EAFGNACTVINDNSSRFGKYLEMKFTCGGTVVGAQISDYLLEKSRVVHHAVGERNFHIFYYIYAG 562

  Fly   238 -ADEALLQELRLERALDTYSYLTDGLNGTVTRIND-------ADSFKQVQQALTVIDFTKEEQRE 294
             |:...|...:|..: .|..||.   |..|..:.|       .:.|:.|:|...||.||.||...
Zfish   563 LAERKKLGHYKLSDS-KTPRYLH---NENVKLVPDIVGNAFYKEQFETVEQCFKVIGFTLEELGS 623

  Fly   295 IFGIVASILHLGNVGFTEVEG-----NAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGDV 354
            ::||:|.||:.|:|.||.|..     .:.:::..::.:||.||.:.|.||:.|||...:..||:.
Zfish   624 VYGILAGILNTGDVEFTSVASEHQTDKSNISNMAVLESAASLLCIRADELQEALTSHCVVTRGET 688

  Fly   355 VTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNV---MGILDIYGFEIFQ 416
            :......|.|...|||:.||:|.|||||:|.|:| ||...:.::..::.   :|||||:|||.|:
Zfish   689 IVRSNTVEKATEVRDAMGKALYGRLFSWIVNRIN-SLLKPDNQSGEDDKGLNIGILDIFGFENFK 752

  Fly   417 KNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISIL 481
            :|||||.|||..||::|..|.:.....|||||..|.::...:||.||:.:.:|..:|..|::|:|
Zfish   753 RNSFEQLCINIANEQIQFYFNQHIFAWEQDEYLNEDVDARVIEYEDNRPLLDLFLQKPMGMLSLL 817

  Fly   482 DEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFL 546
            |||...| :.||:|.:||....|...:.:        ..|::.|  .|.:.||||:|.|:..|||
Zfish   818 DEESRFP-QATDQTLVEKFEDNLKSKNFW--------RPKRVDL--GFGIHHYAGKVIYNAGGFL 871

  Fly   547 DKNNDLLFRDL----------------KETLSKAGN---------GIVR------------NC-- 572
            .||.|.|..|:                ...|:|.||         |..|            :|
Zfish   872 AKNRDALPADIVLLLRSSENELTRKLVTHPLTKTGNLAHTKGKAVGSARMGTQQSQRFAKLDCLL 936

  Fly   573 ------FPEKELRSLKRP----------------------------------ETAITQFRASLNN 597
                  |.|...|.|..|                                  :|..:.||.||.:
Zfish   937 LFSSVSFSESSSRKLTPPIDKSMLALPVDSVQTTESTGDTTHHPRETTNMKTQTVASYFRYSLMD 1001

  Fly   598 LMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERY 662
            |:..::..:|.::||||||:.:.|:.|:.|.||.|::|.|::|..::||.|:::|..:..|:|||
Zfish  1002 LLSKMVAGQPHFVRCIKPNNDRQAHKFDREKVLIQLRYTGILETAKIRRQGYSHRILFNNFIERY 1066

  Fly   663 KSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRT------LFDTED---- 717
            ..|:...  |.:....|:.....|.|.   ..|.:.:|:||:|:::...      :..|.|
Zfish  1067 SILAFRA--NEEPAISPETCAVILEKA---KLENWILGKTKVFLKYYHVEQLNLMVRQTTDRIVL 1126

  Fly   718 --AY-------------QEKKHEIAAIIQAHWKGLMQRRKYL----KLRAQVII--MQSYCRRKL 761
              ||             :||:.:.|.::|:.::|...|:...    |.:::::.  :|::||..|
Zfish  1127 VQAYVRGWMAFKRYCLLKEKREQSAVVLQSAYRGHKARKSIADDRSKAKSEIVFTQLQAWCRGYL 1191

  Fly   762 AQQAAK----KRREAADKIRAFIKG------FITRNDAPNGFNEEFIANAKRMWLLRLAKELPTK 816
            |:|..|    ::.:||.||:|..:|      |..:.:|....|.|   ..:|:      .|:|.:
Zfish  1192 ARQNYKELLDEKNKAAAKIQAHYRGQKERKSFQRKKEAMQKENTE---KTERV------TEVPLE 1247

  Fly   817 VLD--KSWPHAPG-------HCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKG 872
            ..|  ...|...|       ..|:|:.:|...:|.:           :::::|:.:....|...|
Zfish  1248 ADDPVSEEPLQEGGEVEMDDADEKAAVVLQSNYRGY-----------RERKKFKERQERNKTLSG 1301

  Fly   873 KKNNYASSVSTWF---------QEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCT---KFDRHGY 925
            .:.:.:||.....         :||  .:|::::..:.|....|.|..:.::...   :.:..|:
Zfish  1302 DELDASSSTPEEMTSGEDLEATRED--TQENVEKEGNEVEEGGGDEDPEQEAKAATVLQSNFRGH 1364

  Fly   926 KSRDRFILLSNKAIYVLDGKTYK---QKHRLPL-------------DKIDFTLTN 964
            |.|.|  |.....|.|...|..|   .:..||:             ::::||..|
Zfish  1365 KERKR--LQEEGKIPVRGKKEIKSPTDEEELPIPDPPPPEELMEFSEEMEFTEEN 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	261/755 (35%)
		Myosin_TH1	863..1049	CDD:461801	24/130 (18%)
myo3a	XP_068073147.1	Protein Kinases, catalytic domain	17..302	CDD:473864
		MYSc_Myo3	379..1106	CDD:276830	263/760 (35%)
		MBD_Myo3a	1577..1625	CDD:439318