Protein Alignment Myo61F and Myo3b

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001380706.1
• Gene: Myo3b / 366069
• RGDID: 1560313
• Length: 1333
• Species: Rattus norvegicus
• Alignment Length: 922
• Identity: 293/922 - (31%)
• Similarity: 461/922 - (50%)
• Gaps: 178/922 - (19%)

  Fly    26 KMETGL-HERDRAG----VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLP 85
            :|.||. |..:.||    ..|.|.|| ...|:..|..|:||:.:.|||||:|.:||::||::.|.
  Rat   343 RMHTGRPHHVEDAGKCCLEDDLVNLE-VLDEDTIIYWLQKRYADALIYTYVGDILIALNPFQNLS 406

  Fly    86 IYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIA- 149
            ||:....:.|........||||||..|||::.|:..::.||::|||||||||||.:..::|.:.
  Rat   407 IYSPQFSRLYHGVKRSSNPPHIFASADNAYQCLVTFSKDQCIVISGESGSGKTENAHLIVQHLTF 471

  Fly   150 -ACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLL 213
             ..:.|||    ::.|:|:.|.::||||||:|..||||||||||:::.|...||.:|..|..|||
  Rat   472 LGKANNQT----LRQKILQVNSLVEAFGNARTAINDNSSRFGKYLEMMFTPTGAVMGARISEYLL 532

  Fly   214 EKSRVVAQMGGERNFHIFYQLLAGA-DEALLQELRLER-------ALDTYSYLTDGLNGTVTRIN 270
            |||||:.|..||:||||||.:.||. .:..|.|.||..       |.:|.....|        |.
  Rat   533 EKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEFRLPEEKPPRYIAAETERVTQD--------IT 589

  Fly   271 DADSFKQ----VQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEG-----NAKVNSRDLVV 326
            ..:|:::    :|....:|.||.:|...::.|:|.||::||:.|..:..     .::|.:.:.:.
  Rat   590 SKESYRRQFDVIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNPEALE 654

  Fly   327 TAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISL 391
            .||.:|.:|:.||:.|||...:..||:.:......:.|...|||::||:|.|||||:|.|:|..|
  Rat   655 NAASVLCINSEELQEALTSHCVVTRGETIVRANTVDRAEDVRDAMSKALYGRLFSWIVNRINTLL 719

  Fly   392 QAKETRAS---RNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGI 453
            |..:...|   |.|| |||||:|||.||:|||||.|||..||::|..|.:.....||.||::||:
  Rat   720 QPDKNICSAEDRMNV-GILDIFGFEDFQRNSFEQLCINIANEQVQFYFNQHVFALEQMEYKKEGV 783

  Fly   454 EWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPA 518
            :.:.|:|.||:.:.::..:|..|::::||||...| :.||:|.::|....|.      |
  Rat   784 DAVLVQYEDNRPLLDMFLQKPLGLLALLDEESRFP-QGTDQTLVDKFEDNLR------C------ 835

  Fly   519 HIKKIMLRDE-----FRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCF----- 573
               |...|.:     |.:.||||.|.|..:|.|:||.|.|..|:...|..:.|.:::..|
  Rat   836 ---KFFWRPKGVELSFGIQHYAGPVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLT 897

  Fly   574 --------------------------------------PEKELRSLKRPETAITQFRASLNNLMD 600
                                                  || |..::|| :|..:.||.||.:|:.
  Rat   898 KTGNLAQTRARITASSRSLPPHFSAGRAKVDTLEVIRHPE-ETTNMKR-QTMASYFRYSLMDLLS 960

  Fly   601 ILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSL 665
            .::..:|.::|||||||.:.|..|:.:.||.|::..|::|.:.:||.|:::|..:|.|:.||..|
  Rat   961 KMVVGQPHFVRCIKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRILFEEFVRRYYYL 1025

  Fly   666 SKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYR-----VGETKLFIRWPRTLFDTEDAYQEKKHE 725
            :      ::....|.|..:..|..|    ||.|     :|:||:|:::          |..::..
  Rat  1026 A------FRAHQTPPANKESCVAIL----EKSRLDHWVLGKTKVFLKY----------YHIEQLN 1070

  Fly   726 I--------AAIIQAHWKGLMQRRKYLKLRAQ----VIIMQS----YCRRKLAQQAAKKRREAAD 774
            :        ..::||:.||.:..|:|.:.:.:    .|.:||    |..|:..:|...:|.|:|.
  Rat  1071 LLLREVMGRVVMLQAYTKGWLGARRYKRAKEKREKSAITIQSAWRGYDTRRKFKQTRHRRNESAA 1135

  Fly   775 KIRAFI------KGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSW-PH-------- 824
            ..:|.:      |.|.......|..:||            .::..|.:. |..| |.
  Rat  1136 HTQAVLQTTPDEKRFPDSGVESNSRHEE------------TSRNCPAEA-DTDWHPQTQSSPASS 1187

  Fly   825 --APGHCEEASG 834
              ..||.::.:|
  Rat  1188 DVTSGHADKEAG 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	253/729 (35%)
		Myosin_TH1	863..1049	CDD:461801
Myo3b	NP_001380706.1	Protein Kinases, catalytic domain	20..310	CDD:473864
		MYSc_Myo3	373..1062	CDD:276830	253/729 (35%)
		IQ	1102..1124	CDD:197470	5/21 (24%)