Protein Alignment Myo61F and Mhc

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1070
• Identity: 325/1070 - (30%)
• Similarity: 513/1070 - (47%)
• Gaps: 190/1070 - (17%)

  Fly    48 YQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTD 112
            |.::.:.:.||::|:...|||||.|...:::||||:.|:||:...|.||.|...|:||||||::|
  Fly    96 YLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISD 160

  Fly   113 NAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVK------DKLLKSNPV 171
            .|:..::..:..|.:||:||||:||||.:|||:.:.|....::.|.|..|      |:::::|||
  Fly   161 GAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPV 225

  Fly   172 LEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLA 236
            |||||||||.||||||||||::.|.|...|...|.:|..|||||:||::|...||::|||||:::
  Fly   226 LEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMS 290

  Fly   237 GADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVAS 301
            |:...:.....|...:..|..::.| ..||..|:||:.|....||..::.|||:|:.:::.|.|:
  Fly   291 GSVPGVKDICLLTDNIYDYHIVSQG-KVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAA 354

  Fly   302 ILHLGNVGFTE--VEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELA 364
            ::|:|.:.|.:  .|..|:.:..:.....::|.|.:.:||...|....|....:.||...|.:..
  Fly   355 VMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQV 419

  Fly   365 IYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCN 429
            ..:..||.|.|:||||.|||::.|.:|   :|:..|.:.:|:|||.|||||:.|.|||.||||.|
  Fly   420 TNSIGALCKGVFDRLFKWLVKKCNETL---DTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTN 481

  Fly   430 EKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDK 494
            |||||.|.......||:||:||||||..:::..:..:|..:.||..||:|||:||.:.| :.||:
  Fly   482 EKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEEESMFP-KATDQ 545

  Fly   495 TFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKE 559
            ||.||||.   .|.......:.|...|.......|.:.||||.|:|::.|:|:||.|.|...:.:
  Fly   546 TFSEKLTN---THLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVD 607

  Fly   560 TLSKAGNGIVRNCFPE-----------KELRSLKRP--ETAITQFRASLNNLMDILMCKEPSYIR 611
            ...|:.|.::...|.:           |..|..|..  .|..:.::..||:||..|...:|.::|
  Fly   608 QFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVR 672

  Fly   612 CIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGP 676
            ||.||:::...|.:..||:||:...|::|.:|:.|.||..|..|..|..|||.:....   .:|.
  Fly   673 CIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL---LQGV 734

  Fly   677 GGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRR 741
            ...|...:.::|.:...|::||:|.||:|.| ...|...|:...|:..:|.:.:||..:|.:.|:
  Fly   735 EKDKKATEIIIKFIDLPEDQYRLGNTKVFFR-AGVLGQMEEFRDERLGKIMSWMQAWARGYLSRK 798

  Fly   742 KYLKLRAQVI---IMQSYCRRKL-----------------------------AQQAAKKRRE--A 772
            .:.||:.|.:   ::|...|:.|                             .::.|||..|  |
  Fly   799 GFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHA 863

  Fly   773 AD-KIR---------------AFIKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKS 821
            |: |:|               |.:........|...:.|.   |||   |.....:|..::.|
  Fly   864 AEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQER---NAK---LTAQKNDLENQLRD-- 920

  Fly   822 WPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYAS---SVST 883
                         |..||.:...||          .:.|:.|..|::...|.|.:...   :|..
  Fly   921 -------------IQERLTQEEDAR----------NQLFQQKKKADQEISGLKKDIEDLELNVQK 962

  Fly   884 WFQEDRIPKEH-IQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKT- 946
             .::|:..|:| |:.:||.:|                       .:|..|...||. ..:.|:|
  Fly   963 -AEQDKATKDHQIRNLNDEIA-----------------------HQDELINKLNKE-KKMQGETN 1002

  Fly   947 -------------------YKQKHRLPLDKIDFTLTNHNDDLMVIRIPLDLKKDK----GDLILI 988
                               .|.|....||:::.:|....      ::..|::|.|    |||.|
  Fly  1003 QKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREK------KVRGDVEKSKRKVEGDLKL- 1060

  Fly   989 IPRIIEFSTYIIDTVGTASIVSIVDRNSLE 1018
                            |...|:.::||..|
  Fly  1061 ----------------TQEAVADLERNKKE 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	251/675 (37%)
		Myosin_TH1	863..1049	CDD:461801	35/184 (19%)
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	251/675 (37%)
		Myosin_tail_1	842..1922	CDD:460256	58/312 (19%)