Protein Alignment Myo61F and ck

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001285949.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 1127
• Identity: 362/1127 - (32%)
• Similarity: 542/1127 - (48%)
• Gaps: 240/1127 - (21%)

  Fly    31 LHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAY 95
            :|.....||:|.:.|.:.. |...:.||..|::|:|||||.|.:|::||||:.|||||.|.:|.|
  Fly    57 MHASSVQGVEDMISLGDLH-EAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLY 120

  Fly    96 RNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG 160
            :.:...|:||||||:.|||:..:....:.||::||||||:||||::|.:||::||.||..:.:|
  Fly   121 KERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIE- 184

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
              .::|::||:|||||||||.|||||||||||:||.|...|...|..|..|||||||:|:|...|
  Fly   185 --QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSE 247

  Fly   226 RNFHIFYQLLAG--ADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFT 288
            ||:|:||.:|||  |||.  ..|.|..|.| |.|||.|.:.|....:||..|..::.|:.|:.|:
  Fly   248 RNYHVFYCILAGLSADEK--SRLDLGMAAD-YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFS 309

  Fly   289 KEEQREIFGIVASILHLGNVGF----------TEVEGNAKVNSRDLVVTAARLLGVNASELEAAL 343
            .:|..||..::|::||.||:.:          ||:..:..|.      ..|.|||:....|..||
  Fly   310 DQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVE------RVAGLLGLPIQPLIDAL 368

  Fly   344 THRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILD 408
            |.||:.|.|:.|.|.|:::.::..|||..|.:|.|:|..:|:::|.::  .:.|.:..|.:|:||
  Fly   369 TRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLD 431

  Fly   409 IYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEK 473
            |:|||.|.:|||||||||:.||.|||.|::...|.||:||..|.|.|..:|:.||:...:||..|
  Fly   432 IFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIK 496

  Fly   474 HKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEV 538
            ...|::::|||...| :.||:|.|.||.:....|.:|:    .|    |..:...|.|.|:||.|
  Fly   497 QLNIMALIDEEARFP-KGTDQTMLAKLHKTHGSHKNYL----KP----KSDINTSFGLNHFAGVV 552

  Fly   539 TYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFP---EKELRSLKRPETAITQFRASLNNLMD 600
            .|...||||||.|....||...:|::.|..:|..|.   |....:.||..|..||||.||:.||.
  Fly   553 FYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMK 617

  Fly   601 ILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSL 665
            .|...:|.:|||||||:|:...:|:..|...|::|.|:||.:|:||||:..|..:..|:|||:.|
  Fly   618 TLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFL 682

  Fly   666 SKSTWPNYKGPGGPKA------GVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKH 724
            .         ||.|.|      .....:..:...:..|::|.||:|::      |..|.:.|::.
  Fly   683 I---------PGVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLK------DAHDLFLEQER 732

  Fly   725 EIA-----AIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFI 784
            :..     .|:|...:|.:.||::|:|||                       ||..::.|.||:.
  Fly   733 DRVLTRKILILQRSIRGWVYRRRFLRLRA-----------------------AAITVQRFWKGYA 774

  Fly   785 TRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHC----EEASGILHR------- 838
            .|....|          .|:..:||...:.::||...:.|..||.    ..|.|.|.|
  Fly   775 QRKRYRN----------MRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKM 829

  Fly   839 ---------LHRLHLARIYR-LKLTPQQKRQF----ELKVLAEKVFKGKKNNYASSVSTWFQEDR 889
                     :.|:...|.|| |:|   :.:||    :|:.|.|:....:.|.:|..::.....||
  Fly   830 WAVIKIQSHVRRMIAMRRYRKLRL---EHKQFAEVLQLRKLEEQELLHRGNKHAREIAEQHYRDR 891

  Fly   890 IPK-------------------------------------------------------------- 892
            :.:
  Fly   892 LHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRE 956

  Fly   893 -------EHIQRVN--DFVASTFGSE------QLKYQSFCTKFDR----HGYKSRDRFILLSNKA 938
                   .|.|.||  |.:|....||      :.|:|.|...:.:    |.|         :.||
  Fly   957 TSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQY---------AKKA 1012

  Fly   939 IYVLDGKTYKQKHRLPLDKIDFTLTNHNDDLMVIRIPLDLKKDKGDLILIIPRIIEFSTYIIDTV 1003
            :          ||.|      ..|....|.|....:.:.:.:..||:    |   |...:.:|.:
  Fly  1013 L----------KHPL------LPLHTQGDQLAAQALWITILRFTGDM----P---EPKYHTMDRM 1054

  Fly  1004 GTASIVSIVDRNSLEHNVVKGK 1025
            .|.|::|.|.. :|..|.::.|
  Fly  1055 DTTSVMSKVTA-TLGRNFIRSK 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	285/708 (40%)
		MYSc_Myo1	52..707	CDD:276829	277/675 (41%)
		Myosin_TH1	863..1035	CDD:283635	39/244 (16%)
ck	NP_001285949.1	MYSc	64..733	CDD:214580	285/707 (40%)
		MYSc_Myo7	77..721	CDD:276832	277/675 (41%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940