DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo1d

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_036012676.1	Gene:	Myo1d / 338367	MGIID:	107728	Length:	1010	Species:	Mus musculus

Alignment Length:	1037	Identity:	414/1037 - (39%)
Similarity:	598/1037 - (57%)	Gaps:	116/1037 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQ 125
            ||::..|||:||:|::||||||.|.||..|.|:.|:.:..||.|||:||:.|.|::::...::..
Mouse    36 RFEKGRIYTFIGEVVVSVNPYKVLNIYGRDTVEQYKGRELYERPPHLFAIADAAYKAMKRRSKDT 100

  Fly   126 CVLISGESGSGKTEASKKVLQFIAACS--GNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSR 188
            |::||||||:|||||||.::|:|||.:  ..:..:|.||:.|||||.||||||||||||||||||
Mouse   101 CIMISGESGAGKTEASKYIMQYIAAITNPSQRAEIERVKNMLLKSNCVLEAFGNAKTNRNDNSSR 165

  Fly   189 FGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALD 253
            |||||||.|||||.||||:|.|||||||||:.|..|||:||.|||||.|..|.:|..|.|:::|.
Mouse   166 FGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLHSLHLQKSLS 230

  Fly   254 TYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAK 318
            :|:|:..|.. ..:.||||..||.|..|:.||.|..||.:.::.|:|.||||||:.|. |:|:..
Mouse   231 SYNYIRVGAQ-LKSSINDAAEFKVVADAMKVIGFKPEEIQTVYKILAVILHLGNLKFI-VDGDTP 293

  Fly   319 VNSRDLVVTA-ARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSW 382
            :.....||:. |.||...|..:|.||.:||:....|::.....::.|.|.|||.|||:|:|||.|
Mouse   294 LIENGKVVSVIAELLSTKADMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCW 358

  Fly   383 LVQRLNISLQAKE---TRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSE 444
            :|.|:|..::.|.   |...:|.|:|:|||||||||..|||||||||:||||||||||:|.||.|
Mouse   359 IVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQE 423

  Fly   445 QDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHH 509
            |:||:||||.|..::||:|::|.:|:|::|||||:|||:.|:..|:.||..|||.|..||.:|.|
Mouse   424 QEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDGMFLEALNSKLGKHGH 488

  Fly   510 YVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFP 574
            : ...|..|..|.:....:||:.||||:|.||..||:|||.|.||:|.|..:..:.|.:::|.:|
Mouse   489 F-SSRKTCASDKILEFDRDFRIRHYAGDVVYSAIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWP 552

  Fly   575 EKEL---RSLKRPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYL 636
            |.:|   ...|||.||.|.|:.|:..|:|.|..|||.|:|||||||.::..:|:||...|||:||
Mouse   553 EGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYL 617

  Fly   637 GLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGW-DEEKYRVG 700
            ||:||:||||||||:|:|||.||.|||.:|:.||||:..| ..|..|::|::..|: |:..|  |
Mouse   618 GLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLP-SDKEAVKKLIERCGFQDDVAY--G 679

  Fly   701 ETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQA 765
            ::|:|||.|||||..|:...:....:...:|..|:|.:.|.:|.:.:|.:.|::.|.|.|
Mouse   680 KSKIFIRTPRTLFTLEELRAQMLVRVVLFLQKVWRGTLARMRYKRTKAALTIIRYYRRYK----- 739

  Fly   766 AKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAP---G 827
                          :|.:|..             .|:|...::..::....|   .||..|   .
Mouse   740 --------------VKSYIHE-------------VARRFHGVKNMRDYGKHV---KWPTPPKVLR 774

  Fly   828 HCEEA-SGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKK----------NNYASS- 880
            ..||| ..|.:|.....|.:.......||.:    .||.|.::.||::          .||.:|
Mouse   775 RFEEALQSIFNRWRASQLIKTIPASDLPQVR----AKVAAMEMLKGQRADLGLQRAWEGNYLASK 835

  Fly   881 -----VSTWFQEDRIP-KEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAI 939
                 .|..|    :| ...::|.:.::...|.....|...|.        |..||.|.::::.:
Mouse   836 PDTPQTSGTF----VPVANELKRKDKYMNVLFSCHVRKVNRFS--------KVEDRAIFVTDRHL 888

  Fly   940 YVLD-GKTYKQKHRLPLDKI-DFTLTNHNDDLMVIRIPLDLKKDKGDLILIIPRIIEFSTYIIDT 1002
            |.:| .|.||....:||..: ..:::|..|.|:|..     .||..|||:.:     ||......
Mouse   889 YKMDPTKQYKVMKTIPLYNLTGLSVSNGKDQLVVFH-----TKDNKDLIVCL-----FSKQPTHE 943

  Fly  1003 VGTASIVSIV------DRNSLEHNV-------VKGKGGVIDIQT---GAEPGVVRDKGHLVI 1048
            .....:|.::      ::..|:.||       :.||...:.::|   ..:|...:::...::
Mouse   944 SRIGELVGVLVNHFKSEKRHLQVNVTNPVQCSLHGKKCTVSVETRLNQPQPDFTKNRSGFIL 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	343/668 (51%)
		MYSc_Myo1	52..707	CDD:276829	335/655 (51%)
		Myosin_TH1	863..1035	CDD:283635	44/206 (21%)
Myo1d	XP_036012676.1	MYSc_Myo1	36..686	CDD:276829	335/655 (51%)
Myo1d	XP_036012676.1	Myosin_TH1	807..1000	CDD:399188	45/214 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720