Protein Alignment Myo61F and Myo10A

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Alignment Length: 826
• Identity: 296/826 - (35%)
• Similarity: 443/826 - (53%)
• Gaps: 125/826 - (15%)

  Fly    37 AGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLP-IYTDDHVKAYRNKHF 100
            :||:|..||::.. |.:.:.||:.|:.:.||||:.|.:||:|||||..| .|..:..|.|..:..
  Fly   155 SGVEDMTLLDDLH-EASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPL 218

  Fly   101 YEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAAC---SGNQTTVEGVK 162
            ..:|||:||:...|..:|...   |.|:|||||||||||::|.|:|::||.   .|:.:.|  :.
  Fly   219 GSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAV--IT 278

  Fly   163 DKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERN 227
            :::|::.|:|||||||:|.|||||||||||:::.|. .||.:|..|..|||||||:|.|..||||
  Fly   279 EQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERN 342

  Fly   228 FHIFYQLLAGADEALLQELRLERALDTYSYL----TDGLNGTVTRINDADSFKQVQQALTVIDFT 288
            :|:||:||.|..|....:..|..| |.|.||    ||..:|.|       .::.:|.|:.|:..:
  Fly   343 YHVFYELLGGLSETERSKYGLLEA-DKYFYLNQGATDCASGRV-------DWESLQGAMQVLGVS 399

  Fly   289 KEEQREIFGIVASILHLGNVGF-----------TEVEGNAKVNSRDLVVTAARLLGVNASELEAA 342
            :.|:..|..::|::||||||.|           .||..:|::.      .||.||.::|..|..|
  Fly   400 EGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK------WAAHLLHISADGLHRA 458

  Fly   343 LTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGIL 407
            ||.||.:||.:.:.:||..:.|:.||||.|||:|..||:|||.|:|..:|...|..:..  :.||
  Fly   459 LTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISIL 521

  Fly   408 DIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEE 472
            ||:|||...:|||||.|||:.||.||..|.:...|.||.||.||.:||.|:.:.||..:.:|:.:
  Fly   522 DIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAK 586

  Fly   473 KHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGE 537
            |..||..:||:|...| ..||.:||||.        || .|..:..:.:..:...||.:.||||:
  Fly   587 KPVGICHLLDDESNFP-RATDLSFLEKC--------HY-NHALSELYARPRIGAQEFGVTHYAGQ 641

  Fly   538 VTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLK-------------------R 583
            |.|.|:||||||.|.|..|:.|.|:.:...:|...  .|:||:.:                   |
  Fly   642 VWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL--TKQLRAQRDAGKTLPKGSNGRFVTMKPR 704

  Fly   584 PETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAG 648
            ..|...:|..||..|:..:....|.::||||||..:.|...:...||.|::|||:::.:::|:.|
  Fly   705 TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769

  Fly   649 FAYRRTYELFLERYKSLSKSTWPNYKG-----------PGGPKAGVQQLVKDLGWDEEKYRVGET 702
            :..|..::.|:|||:.|..|  |..:|           ...|:.||:      |.|   |::|.|
  Fly   770 YPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVE------GPD---YQLGAT 823

  Fly   703 KLFIR--WPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQA 765
            ::|:|  ..|.|   |....|:....|..:|.|.:|::.||:..:.:|....:|:..|.:.|||.
  Fly   824 RVFLREALHRAL---ESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR 885

  Fly   766 AKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLLRLAK 811
            .::.|          ||.:|               |:|:|..|.|:
  Fly   886 YERLR----------KGALT---------------AQRLWRGRQAR 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	264/703 (38%)
		Myosin_TH1	863..1049	CDD:461801
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	264/703 (38%)
		PTZ00121	<828..>943	CDD:173412	26/107 (24%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022