DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo10A

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	296/826 - (35%)
Similarity:	443/826 - (53%)	Gaps:	125/826 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLP-IYTDDHVKAYRNKHF 100
            :||:|..||::.. |.:.:.||:.|:.:.||||:.|.:||:|||||..| .|..:..|.|..:..
  Fly   155 SGVEDMTLLDDLH-EASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPL 218

  Fly   101 YEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAAC---SGNQTTVEGVK 162
            ..:|||:||:...|..:|...   |.|:|||||||||||::|.|:|::||.   .|:.:.|  :.
  Fly   219 GSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAV--IT 278

  Fly   163 DKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERN 227
            :::|::.|:|||||||:|.|||||||||||:::.|. .||.:|..|..|||||||:|.|..||||
  Fly   279 EQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERN 342

  Fly   228 FHIFYQLLAGADEALLQELRLERALDTYSYL----TDGLNGTVTRINDADSFKQVQQALTVIDFT 288
            :|:||:||.|..|....:..|..| |.|.||    ||..:|.|       .::.:|.|:.|:..:
  Fly   343 YHVFYELLGGLSETERSKYGLLEA-DKYFYLNQGATDCASGRV-------DWESLQGAMQVLGVS 399

  Fly   289 KEEQREIFGIVASILHLGNVGF-----------TEVEGNAKVNSRDLVVTAARLLGVNASELEAA 342
            :.|:..|..::|::||||||.|           .||..:|::.      .||.||.::|..|..|
  Fly   400 EGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK------WAAHLLHISADGLHRA 458

  Fly   343 LTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGIL 407
            ||.||.:||.:.:.:||..:.|:.||||.|||:|..||:|||.|:|..:|...|..:..  :.||
  Fly   459 LTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISIL 521

  Fly   408 DIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEE 472
            ||:|||...:|||||.|||:.||.||..|.:...|.||.||.||.:||.|:.:.||..:.:|:.:
  Fly   522 DIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAK 586

  Fly   473 KHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGE 537
            |..||..:||:|...| ..||.:||||.        || .|..:..:.:..:...||.:.||||:
  Fly   587 KPVGICHLLDDESNFP-RATDLSFLEKC--------HY-NHALSELYARPRIGAQEFGVTHYAGQ 641

  Fly   538 VTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLK-------------------R 583
            |.|.|:||||||.|.|..|:.|.|:.:...:|...  .|:||:.:                   |
  Fly   642 VWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL--TKQLRAQRDAGKTLPKGSNGRFVTMKPR 704

  Fly   584 PETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAG 648
            ..|...:|..||..|:..:....|.::||||||..:.|...:...||.|::|||:::.:::|:.|
  Fly   705 TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769

  Fly   649 FAYRRTYELFLERYKSLSKSTWPNYKG-----------PGGPKAGVQQLVKDLGWDEEKYRVGET 702
            :..|..::.|:|||:.|..|  |..:|           ...|:.||:      |.|   |::|.|
  Fly   770 YPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVE------GPD---YQLGAT 823

  Fly   703 KLFIR--WPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQA 765
            ::|:|  ..|.|   |....|:....|..:|.|.:|::.||:..:.:|....:|:..|.:.|||.
  Fly   824 RVFLREALHRAL---ESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR 885

  Fly   766 AKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLLRLAK 811
            .::.|          ||.:|               |:|:|..|.|:
  Fly   886 YERLR----------KGALT---------------AQRLWRGRQAR 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	274/733 (37%)
		MYSc_Myo1	52..707	CDD:276829	264/703 (38%)
		Myosin_TH1	863..1035	CDD:283635
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	273/728 (38%)
		MYSc_Myo15	169..828	CDD:276838	264/703 (38%)
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940