Protein Alignment Myo61F and Myo5c

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_006243475.1
• Gene: Myo5c / 315820
• RGDID: 1309994
• Length: 1749
• Species: Rattus norvegicus
• Alignment Length: 1067
• Identity: 340/1067 - (31%)
• Similarity: 529/1067 - (49%)
• Gaps: 162/1067 - (15%)

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQED-LIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFY 101
            |..|...| :|..|.|.:.||:.||.|. |||||.|.:|:::|||||||||.|..:.||..::..
  Rat    68 GENDLTAL-SYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMG 131

  Fly   102 EMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLL 166
            :|.||||||.:.|::.:...||.|.:::|||||:|||.:::..:::.|..|.:.:... |::|:|
  Rat   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSSSNAH-VEEKVL 195

  Fly   167 KSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIF 231
            .|||:.||.|||||.|||||||||||.:|.||.:...||.|:..|||||||||.|...|||:|||
  Rat   196 ASNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHIF 260

  Fly   232 YQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIF 296
            |||.|.|.::..:.|:|..| :.::|...|.|..:..::|.....:.|:..|::.|.|:.|.::|
  Rat   261 YQLCASAQQSEFKHLKLGSA-EEFNYTRMGGNTVIEGVDDRADMAETQKTFTLLGFKKDFQMDVF 324

  Fly   297 GIVASILHLGNVGFTEVEGNAKVNSRD--LVVTAARLLGVNASELEAALTHRTIDARGDVVTSPL 359
            .|:|:|||||||..|.|.......|.|  .:.....|||:...::...|.:|.|....:.|..|:
  Rat   325 KILAAILHLGNVQVTTVGNERSAVSEDDSHLKVFCELLGLETIKVAQWLCNRKIVTSSETVVKPM 389

  Fly   360 NQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFC 424
            .:..||.|||||||.:|..||.::|:::|   ||......::..:|:|||||||.|..|||||||
  Rat   390 TRPQAINARDALAKKIYAHLFDFIVEQIN---QALHFSGKQHTFIGVLDIYGFETFDVNSFEQFC 451

  Fly   425 INFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPG 489
            ||:.||||||.|.....|.||:||.:|.|.|..::::||:.:.:|||.| .||:.:||||||.|
  Rat   452 INYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILELLDEECLLP- 514

  Fly   490 EPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLF 554
            ..||:.:|:||      ::::|  .|.....|..|....|.:.|:|.:|.|...|||:||.|.::
  Rat   515 HGTDENWLQKL------YNNFV--NKNSLFEKPRMSNSSFIIQHFADKVEYQCEGFLEKNRDTVY 571

  Fly   555 RDLKETLSKAGNGIVRNCFPE--------------KELRSLKRPE------TAITQFRASLNNLM 599
            ..|.|.|..:...:....|.|              |..:.:.:|.      |...:||:||..||
  Rat   572 DMLVEVLRASKFHLCAAFFQESPVPSSPFGAMITVKSAKQVIKPNTKHFRTTVGNKFRSSLFLLM 636

  Fly   600 DILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERY-- 662
            :.|....|.|:|||||||.:....|:.:.::.|::..|::|.:|:....:..|.||..|..||
  Rat   637 ETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYLEFYSRYGV 701

  Fly   663 ----KSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKK 723
                :.||.|         ..|...:.::..|..|..:|:.|.||:|.|..:..: .|....:|.
  Rat   702 LMTQQELSLS---------DKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAY-LEKLRLDKL 756

  Fly   724 HEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCR-----RKLAQQAAKKRREAADKIRAFIKGF 783
            .:...:||.|.:|.:||:|:|:.|...:.:|.|.|     ||.....|.|...||..::...:|:
  Rat   757 RQGCIVIQKHVRGWLQRKKFLRERRAALTIQQYFRGQQTVRKAITATALKEAWAAIILQKHCRGY 821

  Fly   784 ITRN-------------DAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGI 835
            :.||             ....||               ||:....|:|.          |..:.|
  Rat   822 LVRNLYQLIRVATITIQAHTRGF---------------LARRRYRKLLQ----------EHKAVI 861

  Fly   836 LHRLHRLHLARIYRLKLTPQQKRQFELKV-LAEKVFKGKKNNYASSVSTWFQEDRIPKEH--IQR 897
            |.:..|..||| .|.    |..|:|.|.: |..:|.:.:|.          .||:..:.|  :::
  Rat   862 LQKYARAWLAR-RRF----QNIRRFVLNIQLTYRVQRLQKK----------LEDQNRENHGLVEK 911

  Fly   898 VNDFVASTFGS----EQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYK---------- 948
            :....|...|.    ::|:.:.......||.|:.:               |:.|:
  Rat   912 LTSLAALRVGDLEKVQRLEAELEKAATHRHSYEEK---------------GRRYRDSMEERLSKL 961

  Fly   949 QKHRLPL----DKIDFTLTNHNDDL------MVIRIPLDLKKDKGDLILIIPRIIEFSTYI---- 999
            |||...|    ::.:.:|....::|      :..::..|::|::... |::.:..|..|..
  Rat   962 QKHNAELESQRERAEQSLQERTEELKEKMDQLTRQLFDDVQKEEQQR-LLLEKSFELKTQAYEKE 1025

  Fly  1000 IDTVGTASIVSIVD-RNSLEHNVVKGK 1025
            |::: ...|.::.| |..|.|.:.:|:
  Rat  1026 IESL-REEIKALKDERTQLHHQLEEGR 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	261/683 (38%)
		Myosin_TH1	863..1049	CDD:461801	32/195 (16%)
Myo5c	XP_006243475.1	MYSc_Myo5	81..741	CDD:276831	261/683 (38%)
		IQ	755..776	CDD:197470	7/20 (35%)
		IQ	831..851	CDD:459869	4/34 (12%)
		SMC_prok_B	<850..>1385	CDD:274008	46/244 (19%)
		Myo5c_CBD	1376..1743	CDD:271260