DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo5c

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_006243475.1	Gene:	Myo5c / 315820	RGDID:	1309994	Length:	1749	Species:	Rattus norvegicus

Alignment Length:	1076	Identity:	341/1076 - (31%)
Similarity:	525/1076 - (48%)	Gaps:	180/1076 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQED-LIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFY 101
            |..|...| :|..|.|.:.||:.||.|. |||||.|.:|:::|||||||||.|..:.||..::..
  Rat    68 GENDLTAL-SYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMG 131

  Fly   102 EMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLL 166
            :|.||||||.:.|::.:...||.|.:::|||||:|||.:::..:::.|..|.:.:... |::|:|
  Rat   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSSSNAH-VEEKVL 195

  Fly   167 KSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIF 231
            .|||:.||.|||||.|||||||||||.:|.||.:...||.|:..|||||||||.|...|||:|||
  Rat   196 ASNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHIF 260

  Fly   232 YQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIF 296
            |||.|.|.::..:.|:|..| :.::|...|.|..:..::|.....:.|:..|::.|.|:.|.::|
  Rat   261 YQLCASAQQSEFKHLKLGSA-EEFNYTRMGGNTVIEGVDDRADMAETQKTFTLLGFKKDFQMDVF 324

  Fly   297 GIVASILHLGNVGFTEVEGNAKVNSRD--LVVTAARLLGVNASELEAALTHRTIDARGDVVTSPL 359
            .|:|:|||||||..|.|.......|.|  .:.....|||:...::...|.:|.|....:.|..|:
  Rat   325 KILAAILHLGNVQVTTVGNERSAVSEDDSHLKVFCELLGLETIKVAQWLCNRKIVTSSETVVKPM 389

  Fly   360 NQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFC 424
            .:..||.|||||||.:|..||.::|:::|   ||......::..:|:|||||||.|..|||||||
  Rat   390 TRPQAINARDALAKKIYAHLFDFIVEQIN---QALHFSGKQHTFIGVLDIYGFETFDVNSFEQFC 451

  Fly   425 INFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPG 489
            ||:.||||||.|.....|.||:||.:|.|.|..::::||:.:.:|||.| .||:.:||||||.|
  Rat   452 INYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILELLDEECLLP- 514

  Fly   490 EPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLF 554
            ..||:.:|:||      ::::|  .|.....|..|....|.:.|:|.:|.|...|||:||.|.::
  Rat   515 HGTDENWLQKL------YNNFV--NKNSLFEKPRMSNSSFIIQHFADKVEYQCEGFLEKNRDTVY 571

  Fly   555 RDLKETLSKAGNGIVRNCFPE--------------KELRSLKRPE------TAITQFRASLNNLM 599
            ..|.|.|..:...:....|.|              |..:.:.:|.      |...:||:||..||
  Rat   572 DMLVEVLRASKFHLCAAFFQESPVPSSPFGAMITVKSAKQVIKPNTKHFRTTVGNKFRSSLFLLM 636

  Fly   600 DILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERY-- 662
            :.|....|.|:|||||||.:....|:.:.::.|::..|::|.:|:....:..|.||..|..||
  Rat   637 ETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYLEFYSRYGV 701

  Fly   663 ----KSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKK 723
                :.||.|         ..|...:.::..|..|..:|:.|.||:|.|..:..: .|....:|.
  Rat   702 LMTQQELSLS---------DKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAY-LEKLRLDKL 756

  Fly   724 HEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCR-----RKLAQQAAKKRREAADKIRAFIKGF 783
            .:...:||.|.:|.:||:|:|:.|...:.:|.|.|     ||.....|.|...||..::...:|:
  Rat   757 RQGCIVIQKHVRGWLQRKKFLRERRAALTIQQYFRGQQTVRKAITATALKEAWAAIILQKHCRGY 821

  Fly   784 ITRN-------------DAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGI 835
            :.||             ....||               ||:....|:|.          |..:.|
  Rat   822 LVRNLYQLIRVATITIQAHTRGF---------------LARRRYRKLLQ----------EHKAVI 861

  Fly   836 LHRLHRLHLARIYRLKLTPQQKRQFELKV-LAEKVFKGKKNNYASSVSTWFQEDRIPKEH--IQR 897
            |.:..|..||| .|.    |..|:|.|.: |..:|.:.:|.          .||:..:.|  :::
  Rat   862 LQKYARAWLAR-RRF----QNIRRFVLNIQLTYRVQRLQKK----------LEDQNRENHGLVEK 911

  Fly   898 VNDFVASTFGS----EQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYK---------- 948
            :....|...|.    ::|:.:.......||.|:.:               |:.|:
  Rat   912 LTSLAALRVGDLEKVQRLEAELEKAATHRHSYEEK---------------GRRYRDSMEERLSKL 961

  Fly   949 QKHRLPL----DKIDFTLTNHNDDLMVIRIPLDLKKDKGDLI---------------LIIPRIIE 994
            |||...|    ::.:.:|....::|          |:|.|.:               |::.:..|
  Rat   962 QKHNAELESQRERAEQSLQERTEEL----------KEKMDQLTRQLFDDVQKEEQQRLLLEKSFE 1016

  Fly   995 FSTYI----IDTVGTASIVSIVD-RNSLEHNVVKGK 1025
            ..|..    |::: ...|.::.| |..|.|.:.:|:
  Rat  1017 LKTQAYEKEIESL-REEIKALKDERTQLHHQLEEGR 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	268/710 (38%)
		MYSc_Myo1	52..707	CDD:276829	261/683 (38%)
		Myosin_TH1	863..1035	CDD:283635	33/204 (16%)
Myo5c	XP_006243475.1	Myosin_N	12..48	CDD:280832
		MYSc	62..752	CDD:214580	268/709 (38%)
		MYSc_Myo5	81..741	CDD:276831	261/683 (38%)
		IQ	755..776	CDD:197470	7/20 (35%)
		IQ	830..851	CDD:197470	4/35 (11%)
		COG1340	890..1150	CDD:224259	32/198 (16%)
		GBP_C	<929..1030	CDD:303769	19/126 (15%)
		RILP-like	<977..1096	CDD:304877	15/86 (17%)
		coiled coil	1001..1010	CDD:293879	0/8 (0%)
		coiled coil	1019..1030	CDD:293879	2/11 (18%)
		Myo5c_CBD	1376..1743	CDD:271260
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910