DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo1f

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001101546.1	Gene:	Myo1f / 314654	RGDID:	1309750	Length:	1098	Species:	Rattus norvegicus

Alignment Length:	984	Identity:	371/984 - (37%)
Similarity:	525/984 - (53%)	Gaps:	172/984 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MDTKDYIDFNSQLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLIS 77
            |.:|:...:.|        |...::||.|.|||... :|:|.:.||:|||.:|.|:||||.||||
  Rat     1 MGSKERFHWQS--------HNVKQSGVDDMVLLPQI-TEDAIVSNLRKRFMDDYIFTYIGSVLIS 56

  Fly    78 VNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASK 142
            |||:||:|.:||..:..|:....||.||||:|:|||.:|:::.:...|||:||||||:|||.|:|
  Rat    57 VNPFKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAK 121

  Fly   143 KVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGN 207
            .::.:|:..||....|:.|||.:|:|||:|||||||||.||:||||||||.:|||...|.|.||.
  Rat   122 YIMGYISKVSGGGDKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGK 186

  Fly   208 ILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDA 272
            |.|:||||||||.|...||||||:||||.||.:...|.|.| ...|.|.||.......|...:|.
  Rat   187 ISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQQQNLGL-MTPDYYYYLNQSDTYKVEGTDDR 250

  Fly   273 DSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGN-AKVNSRDLVVTAARLLGVNA 336
            ..|.:...|:.||......|:.:..:||.||||||:.|.| ||| |:|.|.||:...|.|||:::
  Rat   251 SDFNETLNAMQVIGIPTSVQQLVLQLVAGILHLGNISFCE-EGNYARVESVDLLAFPAYLLGIDS 314

  Fly   337 SELEAALTHRTIDA----RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETR 397
            ..|:..||.|.:|:    |.:.:...||.|.|.|.||||||.:|.|||.:||:.:|.::|..:..
  Rat   315 GRLQEKLTSRKMDSKWGGRSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEE 379

  Fly   398 ASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFD 462
            .|    :|:||||||||||||.||||||||.||||||:|||||||:||:||.:|||.|.|:|||:
  Rat   380 YS----IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFN 440

  Fly   463 NKVICNLIEEK--HKGIISILDEECL---RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKK 522
            ||::|:|||.|  ..||:|:||:.|.   ..|...|:|.|:||...:..|.|:......
  Rat   441 NKIVCDLIENKLNPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWSAG------ 499

  Fly   523 IMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEK-ELRSLKRPET 586
                  |.:.||||:|:|.|:||.::|.|:||.||.|.:..:....:|..|||| ::....||.|
  Rat   500 ------FVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQSSDQAFLRMLFPEKLDVDKKGRPST 558

  Fly   587 AITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAY 651
            |.::.:...|:|:..|....|.||||||||:.:....:.:..|.|||:||||.||:|||||||||
  Rat   559 AGSKIKKQANDLVSTLKKCTPHYIRCIKPNETKRPRDWEESRVKHQVEYLGLRENIRVRRAGFAY 623

  Fly   652 RRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTE 716
            ||.:..||:||..|:..|||.::  |..:.|||.|::.:..:.::|::|.||:|::.|.:||..|
  Rat   624 RRQFSKFLQRYAILTPETWPRWR--GDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLE 686

  Fly   717 DAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIK 781
            :..:.|....|..||..|:..:..|||.::|
  Rat   687 EMRERKFDGFARTIQKAWRRHIAVRKYEEMR---------------------------------- 717

  Fly   782 GFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLAR 846
                                                            ||||.||
  Rat   718 ------------------------------------------------EEASNIL---------- 724

  Fly   847 IYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQL 911
                                    ..||....:|::..|..|.:..|....:..|:|.   .|::
  Rat   725 ------------------------LNKKERRRNSINRNFVGDYLGLEERPELRQFLAK---RERV 762

  Fly   912 KYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQ-----------KHRLPLDKI-DFTLTN 964
            .:....||:||. :|...|.::|:.|.:||:..:..|:           |.:|.:..: ..:|:.
  Rat   763 DFADSVTKYDRR-FKPIKRDLILTPKCVYVIGREKVKKGPEKGLVREVLKKKLEIQALRGVSLST 826

  Fly   965 HNDDLMVIR 973
            ..||..:::
  Rat   827 RQDDFFILQ 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	328/698 (47%)
		MYSc_Myo1	52..707	CDD:276829	316/665 (48%)
		Myosin_TH1	863..1035	CDD:283635	25/123 (20%)
Myo1f	NP_001101546.1	MYSc	12..690	CDD:214580	328/698 (47%)
		MYSc_Myo1	31..677	CDD:276829	316/665 (48%)
		Myosin_TH1	717..899	CDD:283635	32/239 (13%)
		SH3_MyoIe_If_like	1045..1097	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820