Protein Alignment Myo61F and Myo1a

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_062197.1
• Gene: Myo1a / 299509
• RGDID: 3135
• Length: 1043
• Species: Rattus norvegicus
• Alignment Length: 1040
• Identity: 461/1040 - (44%)
• Similarity: 646/1040 - (62%)
• Gaps: 68/1040 - (6%)

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            ||:|.:|||.. .||:.|.||:.|:::..||||||.|:||:|||:|||||..:.:..||:..|||
  Rat     9 GVEDLILLEPL-DEESLIKNLQLRYEKKEIYTYIGNVVISMNPYQQLPIYGPEFIAKYRDYTFYE 72

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLK 167
            :.|||:|:.:.|::||.:.:|.||:||:||||:|||||||.|:.::||..|....|..||::||:
  Rat    73 LKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQ 137

  Fly   168 SNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFY 232
            |||||||||||||.||||||||||||||:|||||:|:||.|.||||||||||.|:.|||||||||
  Rat   138 SNPVLEAFGNAKTIRNDNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNFHIFY 202

  Fly   233 QLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRIN---DADSFKQVQQALTVIDFTKEEQRE 294
            |||||||..||:.|:||.....|:|    |||.|:|:|   ||.:|:.||.|:.||.|::||.|:
  Rat   203 QLLAGADTQLLKALKLEEDARGYAY----LNGEVSRVNGMDDASNFRAVQNAMAVIGFSEEEIRQ 263

  Fly   295 IFGIVASILHLGNVGFT-EVEGN----AKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGDV 354
            :..:.|.:|.||||... |.:.|    :.|.....:.....::|:|::|||.||..||::...:.
  Rat   264 VLEVTALVLKLGNVKLADEFQANGLPASGVCDGKGIQEIGEMMGLNSAELEKALCSRTMETGKEK 328

  Fly   355 VTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNS 419
            |.:.||...|.||||||||.:|.|||.|:|.|:|.|:  |.....:..|||:||||||||.:.||
  Rat   329 VVTVLNVIQAQYARDALAKNIYSRLFDWIVNRINESI--KVGTGEKRKVMGVLDIYGFEILEDNS 391

  Fly   420 FEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEE 484
            ||||.||:|||||||:|||||||.||:||:||||.|..||||||.:||:|||...:||:::||||
  Rat   392 FEQFVINYCNEKLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICDLIEHSQRGILAMLDEE 456

  Fly   485 CLRPGEPTDKTFLEKLTQKLAQHHHYVCH--EKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLD 547
            |||||..:|.|||.||.|..::|.||...  :.|.....:.|....||:.||||:|||:|..|:|
  Rat   457 CLRPGVVSDTTFLAKLNQLFSKHSHYESKVTQNAQRQYDRTMGLSCFRICHYAGKVTYNVTSFID 521

  Fly   548 KNNDLLFRDLKETLSKAGNGIVRNCFPE---KELRSLKRPETAITQFRASLNNLMDILMCKEPSY 609
            ||||||||||.:|:.||.:.::.:.|||   || .|||||.||.|||:.|:..||..|..|.|:|
  Rat   522 KNNDLLFRDLSQTMWKAQHPLLHSLFPEGNPKE-ASLKRPPTAGTQFKNSVAILMKNLYSKNPNY 585

  Fly   610 IRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYK 674
            ||||||||.|....|..|||:.|.:||||:||:||||||:|:|:.|:.|||||:.||:||||.:.
  Rat   586 IRCIKPNDQQQQGRFTSELVMVQARYLGLLENVRVRRAGYAFRQAYKPFLERYRLLSRSTWPRWN 650

  Fly   675 GPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQ 739
            |.  .:.||::::..|....|:...|.||:|||.|:|||..|:..:.:..::|.:||..::|...
  Rat   651 GE--DREGVEKVLGSLILSSEELAYGRTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKVYRGWRC 713

  Fly   740 RRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNE-------EF 797
            |..|.::|...|::.::.|....::...|.|.:...|:||::|:..|.:....|..       .|
  Rat   714 RTHYQQMRKSQILISAWFRGNKQKKHYGKIRSSVLLIQAFVRGWKARKNYRKYFRSGAAITLANF 778

  Fly   798 I-ANAKRMWLLRLAKELP-TKVLDKSWPHAPGHC-EEASGILHRLHRLHLARIYRLKLTPQQKRQ 859
            | .:..:.:||.|.|.|| |||||.:||.||..| ..|:..|..|......:.||.:|:|:|.:.
  Rat   779 IYQSITQKFLLNLKKNLPSTKVLDNTWPAAPYRCFNTANQELQHLFYQWKCKKYRDQLSPKQVQT 843

  Fly   860 FELKVLAEKVFKGKKNNYASSVSTWFQEDRI-----PKEHIQRVND------FVASTFGSEQLKY 913
            ...|:.|.::|||||.:|..||...|:.|.:     ||  :||:..      .||.|
  Rat   844 LREKLCASELFKGKKASYLQSVPVPFRGDYVGLQGNPK--LQRLKGREEGPVLVADT-------- 898

  Fly   914 QSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKI-DFTLTNHNDDLMVIRI-PL 976
               ..|.:|...|:..|.:||:...:.:.|.|..:.:..:.|:.: ..::|:..|.|..:.: .:
  Rat   899 ---VKKVNRGNGKTSSRILLLTKGHVILTDAKKSQAQIVIKLEDVAGVSVTSLEDGLFSLHLSEM 960

  Fly   977 DLKKDKGDLILIIPRIIEFST----YIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQTGAEP 1037
            .....|||::||...::|..|    .::|.......|::.::.|     |:.|.|.:.::....|
  Rat   961 SSAASKGDILLISDHLVELLTKMYQAVLDATQRQLPVTVTEKFS-----VRFKEGSVAVKVTQGP 1020

  Fly  1038  1037
              Rat  1021  1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	359/667 (54%)
		Myosin_TH1	863..1049	CDD:461801	45/192 (23%)
Myo1a	NP_062197.1	MYSc_Myo1	22..681	CDD:276829	359/667 (54%)
		IQ	742..764	CDD:197470	7/21 (33%)
		Myosin_TH1	847..1042	CDD:461801	45/192 (23%)