DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo1a

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_062197.1	Gene:	Myo1a / 299509	RGDID:	3135	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1040	Identity:	461/1040 - (44%)
Similarity:	646/1040 - (62%)	Gaps:	68/1040 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            ||:|.:|||.. .||:.|.||:.|:::..||||||.|:||:|||:|||||..:.:..||:..|||
  Rat     9 GVEDLILLEPL-DEESLIKNLQLRYEKKEIYTYIGNVVISMNPYQQLPIYGPEFIAKYRDYTFYE 72

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLK 167
            :.|||:|:.:.|::||.:.:|.||:||:||||:|||||||.|:.::||..|....|..||::||:
  Rat    73 LKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQ 137

  Fly   168 SNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFY 232
            |||||||||||||.||||||||||||||:|||||:|:||.|.||||||||||.|:.|||||||||
  Rat   138 SNPVLEAFGNAKTIRNDNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNFHIFY 202

  Fly   233 QLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRIN---DADSFKQVQQALTVIDFTKEEQRE 294
            |||||||..||:.|:||.....|:|    |||.|:|:|   ||.:|:.||.|:.||.|::||.|:
  Rat   203 QLLAGADTQLLKALKLEEDARGYAY----LNGEVSRVNGMDDASNFRAVQNAMAVIGFSEEEIRQ 263

  Fly   295 IFGIVASILHLGNVGFT-EVEGN----AKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGDV 354
            :..:.|.:|.||||... |.:.|    :.|.....:.....::|:|::|||.||..||::...:.
  Rat   264 VLEVTALVLKLGNVKLADEFQANGLPASGVCDGKGIQEIGEMMGLNSAELEKALCSRTMETGKEK 328

  Fly   355 VTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNS 419
            |.:.||...|.||||||||.:|.|||.|:|.|:|.|:  |.....:..|||:||||||||.:.||
  Rat   329 VVTVLNVIQAQYARDALAKNIYSRLFDWIVNRINESI--KVGTGEKRKVMGVLDIYGFEILEDNS 391

  Fly   420 FEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEE 484
            ||||.||:|||||||:|||||||.||:||:||||.|..||||||.:||:|||...:||:::||||
  Rat   392 FEQFVINYCNEKLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICDLIEHSQRGILAMLDEE 456

  Fly   485 CLRPGEPTDKTFLEKLTQKLAQHHHYVCH--EKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLD 547
            |||||..:|.|||.||.|..::|.||...  :.|.....:.|....||:.||||:|||:|..|:|
  Rat   457 CLRPGVVSDTTFLAKLNQLFSKHSHYESKVTQNAQRQYDRTMGLSCFRICHYAGKVTYNVTSFID 521

  Fly   548 KNNDLLFRDLKETLSKAGNGIVRNCFPE---KELRSLKRPETAITQFRASLNNLMDILMCKEPSY 609
            ||||||||||.:|:.||.:.::.:.|||   || .|||||.||.|||:.|:..||..|..|.|:|
  Rat   522 KNNDLLFRDLSQTMWKAQHPLLHSLFPEGNPKE-ASLKRPPTAGTQFKNSVAILMKNLYSKNPNY 585

  Fly   610 IRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYK 674
            ||||||||.|....|..|||:.|.:||||:||:||||||:|:|:.|:.|||||:.||:||||.:.
  Rat   586 IRCIKPNDQQQQGRFTSELVMVQARYLGLLENVRVRRAGYAFRQAYKPFLERYRLLSRSTWPRWN 650

  Fly   675 GPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQ 739
            |.  .:.||::::..|....|:...|.||:|||.|:|||..|:..:.:..::|.:||..::|...
  Rat   651 GE--DREGVEKVLGSLILSSEELAYGRTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKVYRGWRC 713

  Fly   740 RRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNE-------EF 797
            |..|.::|...|::.::.|....::...|.|.:...|:||::|:..|.:....|..       .|
  Rat   714 RTHYQQMRKSQILISAWFRGNKQKKHYGKIRSSVLLIQAFVRGWKARKNYRKYFRSGAAITLANF 778

  Fly   798 I-ANAKRMWLLRLAKELP-TKVLDKSWPHAPGHC-EEASGILHRLHRLHLARIYRLKLTPQQKRQ 859
            | .:..:.:||.|.|.|| |||||.:||.||..| ..|:..|..|......:.||.:|:|:|.:.
  Rat   779 IYQSITQKFLLNLKKNLPSTKVLDNTWPAAPYRCFNTANQELQHLFYQWKCKKYRDQLSPKQVQT 843

  Fly   860 FELKVLAEKVFKGKKNNYASSVSTWFQEDRI-----PKEHIQRVND------FVASTFGSEQLKY 913
            ...|:.|.::|||||.:|..||...|:.|.:     ||  :||:..      .||.|
  Rat   844 LREKLCASELFKGKKASYLQSVPVPFRGDYVGLQGNPK--LQRLKGREEGPVLVADT-------- 898

  Fly   914 QSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKI-DFTLTNHNDDLMVIRI-PL 976
               ..|.:|...|:..|.:||:...:.:.|.|..:.:..:.|:.: ..::|:..|.|..:.: .:
  Rat   899 ---VKKVNRGNGKTSSRILLLTKGHVILTDAKKSQAQIVIKLEDVAGVSVTSLEDGLFSLHLSEM 960

  Fly   977 DLKKDKGDLILIIPRIIEFST----YIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQTGAEP 1037
            .....|||::||...::|..|    .::|.......|::.::.|     |:.|.|.:.::....|
  Rat   961 SSAASKGDILLISDHLVELLTKMYQAVLDATQRQLPVTVTEKFS-----VRFKEGSVAVKVTQGP 1020

Fly 1038 1037
Rat 1021 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	373/694 (54%)
		MYSc_Myo1	52..707	CDD:276829	359/667 (54%)
		Myosin_TH1	863..1035	CDD:283635	44/188 (23%)
Myo1a	NP_062197.1	MYSc_Myo1	22..681	CDD:276829	359/667 (54%)
		IQ	742..764	CDD:197470	7/21 (33%)
		Myosin_TH1	847..1042	CDD:399188	45/192 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720