Protein Alignment Myo61F and Myh7

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_058936.1
• Gene: Myh7 / 29557
• RGDID: 62030
• Length: 1935
• Species: Rattus norvegicus
• Alignment Length: 1081
• Identity: 335/1081 - (30%)
• Similarity: 531/1081 - (49%)
• Gaps: 181/1081 - (16%)

  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:| .:..|.|.:.|||:|:...:||||.|...::|||||.||:|....|.|||.|...|.
  Rat    87 IEDMAML-TFLHEPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAQVVAAYRGKKRSEA 150

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG-------NQTTVEG- 160
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|..:.       :||..:|
  Rat   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGT 215

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
            ::|:::::||.|||||||||.||||||||||::.|.|...|.....:|..||||||||:.|:..|
  Rat   216 LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAE 280

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            |::|||||:|:.....||..|.:......|::.:.| ..||..|:|::.......|..|:.||.|
  Rat   281 RDYHIFYQILSNKKPELLDMLLITNNPYDYAFFSQG-ETTVASIDDSEEHMATDSAFDVLGFTPE 344

  Fly   291 EQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGD 353
            |:..|:.:..:|:|.||:.|.:.  |..|:.:..:....:|.|:|:|:::|...|.|..:....:
  Rat   345 EKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNE 409

  Fly   354 VVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKN 418
            .||...|.:...||..||||:||:::|:|:|.|:|.:|   ||:..|...:|:|||.|||||..|
  Rat   410 YVTKGQNVQQVAYAIGALAKSVYEKMFNWMVTRINATL---ETKQPRQYFIGVLDIAGFEIFDFN 471

  Fly   419 SFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDE 483
            ||||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||:|||:|
  Rat   472 SFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEE 536

  Fly   484 ECLRPGEPTDKTFLEKL-TQKLAQHHHYVCHEKAPAHIKKIMLRDE--FRLVHYAGEVTYSVNGF 545
            ||:.| :.||.||..|| ...|.:.:::    :.|.:||.   :.|  |.|:||||.|.|::.|:
  Rat   537 ECMFP-KATDMTFKAKLYDNHLGKSNNF----QKPRNIKG---KQEAHFSLIHYAGTVDYNILGW 593

  Fly   546 LDKNNDLLFRDLKETLSKAGNGIVRNCFP---------EKELRSLKRP---ETAITQFRASLNNL 598
            |.||.|.|...:.....|:...::.|.|.         :|.....|:.   :|.....|.:||.|
  Rat   594 LQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPVDKGKGKAKKGSSFQTVSALHRENLNKL 658

  Fly   599 MDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYK 663
            |..|....|.::|||.||:.::..|.::.||:||::..|::|.:|:.|.||..|..|..|.:||:
  Rat   659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 723

  Fly   664 SLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAA 728
            .|:.:..|..:.....| |.::|:..|..|..:|:.|.||:|.: ...|...|:...|:...|..
  Rat   724 ILNPAAIPEGQFIDSRK-GAEKLLGSLDIDHNQYKFGHTKVFFK-AGLLGLLEEMRDERLSRIIT 786

  Fly   729 IIQAHWKGLMQRRKYLKL---RAQVIIMQSYCRRKLAQQAAKK--RREAADKIRAFIKGFITRND 788
            .|||..:|::.|.::.||   |..::|:|...|   |....|.  ..:...||:..:|...|..:
  Rat   787 RIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIR---AFMGVKNWPWMKLYFKIKPLLKSAETEKE 848

  Fly   789 APNGFNEEF--------IANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLA 845
            ..| ..|||        .:.|:|       |||..|::               .:|
  Rat   849 MAN-MKEEFGRVKDALEKSEARR-------KELEEKMV---------------SLL--------- 881

  Fly   846 RIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASS-------VSTWFQEDRIPKEHIQRVND--F 901
                     |:|...:|:|.||      ::|.|.:       :....|.:...||..:|:.|  .
  Rat   882 ---------QEKNDLQLQVQAE------QDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEE 931

  Fly   902 VASTFGSEQLKYQSFCTKF----------------DRHGYKSR-----------DRFILLSNKAI 939
            :.:...:::.|.:..|::.                ::|..:::           |..|:...|
  Rat   932 MNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIVKLTK-- 994

  Fly   940 YVLDGKTYKQKHRLPLDKIDF------TLTNHN-------DDL-------MVIRIPLDLKKDK-- 982
               :.|..::.|:..||.:..      |||...       |||       ..:|:.|:..|.|
  Rat   995 ---EKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLDQDKKVRMDLERAKRKLE 1056

  Fly   983 GDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVK 1023
            |||.|....|::...               |:..|:..:.|
  Rat  1057 GDLKLTQESIMDLEN---------------DKQQLDERLKK 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	259/679 (38%)
		Myosin_TH1	863..1049	CDD:461801	38/219 (17%)
Myh7	NP_058936.1	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..766	CDD:276951	259/679 (38%)
		Actin-binding	655..677		10/21 (48%)
		Actin-binding	757..771		4/14 (29%)
		Myosin_tail_1	846..1923	CDD:460256	52/304 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1915..1935